SavedAdd your journal

Journals / Avrupa Yaşam Bilimleri Dergisi / 2022 / Cilt: 1 - Sayı: 3

Latest research about active pharmaceutical ingredient loaded Poly Lactic Acid-co-Glycolic Acid (PLGA) based drug delivery system in Türkiye

Berna KAVAL
Fatma Dilara ŞEN
Kemal Kaya BATMAZ
Meliha EKİNCİ
A. Alper ÖZTÜRK
Pages
127–139
Publication Date
2023-02-28
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, we believe that this review is a resource for researchers doing research with PLGA.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Some of the most well-engineered and produced biomaterials are polyesters based on polyglycolic acid (PGA), polylactic acid (PLA), and their copolymers, polylactic acid co-glycolic acid (PLGA).
📊
Key Findings & Data:In controlled release systems, PLGA is the most extensively used and popular polymer.
💡
Conclusion & Impact:In conclusion, we believe that this review is a resource for researchers doing research with PLGA.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:PLGA · Drug Delivery Systems · Drug Carrier

Abstract

Some of the most well-engineered and produced biomaterials are polyesters based on polyglycolic acid (PGA), polylactic acid (PLA), and their copolymers, polylactic acid co-glycolic acid (PLGA). In controlled release systems, PLGA is the most extensively used and popular polymer. Because of its biodegradability, biocompatibility, and favorable release kinetics, but also because of the reliability of protein delivery issues, this synthetic polymer has been found to be very successful. PLGA is approved in various human drug delivery systems by EMA and FDA. In this review, first, PLGA and historical development, usage, physico-chemical structure, drug release properties, degredation specifications, solubility, crystallinity, thermal stability, release properties, types of PLGA will be mentioned. In the last stage of the review, studies conducted in Türkiye are included. In conclusion, we believe that this review is a resource for researchers doing research with PLGA.

🔖

Cite This Article

KAVAL, B., ŞEN, F. D., BATMAZ, K. K., EKİNCİ, M., ÖZTÜRK, A. A. (2023). Latest research about active pharmaceutical ingredient loaded Poly Lactic Acid-co-Glycolic Acid (PLGA) based drug delivery system in Türkiye. Avrupa Yaşam Bilimleri Dergisi, Cilt: 1 - Sayı: 3, 127–139. https://ajindex.com/articles/884178

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (10)

  1. Uhrich KE, Cannizzaro SM, Langer RS, Shakesheff KM. Polymeric systems for controlled drug release. Chem Rev. 1999;99(11):3181-3198. https://doi.org/10.1021/cr940351u Özakar E. Etkin Madde Yüklü PLGA Nanopartiküllerinin Hazırlanması ve in vitro Değerlendirilmesi [master’s thesis]. Erzurum: Atatürk Üniversitesi Sağlık Bilimleri Enstitüsü; 2014.
  2. Tabatabaei Mirakabad FS, Nejati-Koshki K, Akbarzadeh A, et al. PLGA-based nanoparticles as cancer drug delivery systems. Asian Pac J Cancer Prev. 2014;15(2):517-535. https://doi.org/10.7314/apjcp.2014.15.2.517
  3. Erden N, Çelebi N. Biyolojik olarak parçalanabilen polimer sistemlerin peptit ve proteinlere uygulanması: Sürekli etki sağlayan laktid/glikolid mikroküreleri. FABAD J Pharm Sci. 1993;18:161-171.
  4. Hines DJ, Kaplan DL. Poly(lactic-co-glycolic) acid-controlled-release systems: experimental and modeling insights. Crit Rev Ther Drug Carrier Syst. 2013;30(3):257-276. https://doi.org/10.1615/critrevtherdrugcarriersyst.2013006475
  5. Danhier F, Ansorena E, Silva JM, Coco R, Le Breton A, Préat V. PLGA-based nanoparticles: an overview of biomedical applications. J Control Release. 2012;161(2):505-522. https://doi.org/10.1016/j.jconrel.2012.01.043 Avgoustakis K. Polylactic-Co-Glycolic Acid (PLGA). In: Wnek GE, Bowlin GL, editors. Encyclopedia of Biomaterials and Biomedical Engineering. CRC Press; 2008. p. 2291-2301.
  6. Herrero-Vanrell R, Molina-Martinez IT. PLA and PLGA microparticles for intravitreal drug delivery: an overview. J Drug Deliv Sci Technol. 2007;17(1):11-17. https://doi.org/10.1016/S1773-2247(07)50002-X
  7. Sarkar S, Lee GY, Wong JY, Desai TA. Development and characterization of a porous micro-patterned scaffold for vascular tissue engineering applications. Biomaterials. 2006;27(27):4775-4782. https://doi.org/10.1016/j.biomaterials.2006.04.038
  8. Hwang CM, Khademhosseini A, Park Y, Sun K, Lee SH. Microfluidic chip-based fabrication of PLGA microfiber scaffolds for tissue engineering. Langmuir. 2008;24(13):6845-6851. https://doi.org/10.1021/la800253b
  9. Katas H, Cevher E, Alpar HO. Preparation of polyethyleneimine incorporated poly (d, l-lactide-co-glycolide) nanoparticles by spontaneous emulsion diffusion method for small interfering RNA delivery. Int J Pharm. 2009;369(1-2):144-154. https://doi.org/10.1016/j.ijpharm.2008.10.012
  10. Cui W, Bei J, Wang S, et al. Preparation and evaluation of poly(-lactide-coglycolide) (PLGA) microbubbles as a contrast agent for myocardial contrast echocardiography. J Biomed Mater Res B Appl Biomater