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Journals / Avrupa Yaşam Bilimleri Dergisi / 2026 / Volume: 5 Issue: 2

Determination of the antioxidant capacity of some thiazole derivatives using the CUPRAC and DPPH method

Abdullah Biçer(BILECIK SEYH EDEBALI UNIVERSITY)0000-0003-4648-1834
Gökhan Sevinç(BİLECİK ŞEYH EDEBALİ ÜNİVERSİTESİ, FEN-EDEBİYAT FAKÜLTESİ, KİMYA BÖLÜMÜ)0000-0002-7008-1067
Pages
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Publication Date
2026-08-31
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The results reveal that compound (17) possesses poor radical scavenging ability while maintaining significant reducing strength.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study, the antioxidant properties of some thiazole compounds were investigated using the DPPH and CUPRAC methods.
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Key Findings & Data:Urea, amide, and benzyl-substituted thiazole compounds (11, 12, 13) were synthesized from the reactions of 4-phenyl-2-aminothiazole with phenyl isocyanate, acetyl chloride, and benzyl chloride, respectively.
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Conclusion & Impact:The results reveal that compound (17) possesses poor radical scavenging ability while maintaining significant reducing strength.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Antioxidant · CUPRAC · DPPH

Abstract

In this study, the antioxidant properties of some thiazole compounds were investigated using the DPPH and CUPRAC methods. Urea, amide, and benzyl-substituted thiazole compounds (11, 12, 13) were synthesized from the reactions of 4-phenyl-2-aminothiazole with phenyl isocyanate, acetyl chloride, and benzyl chloride, respectively. In addition, compound (17) was obtained from 4-bromoacetophenone, and compound (15) was obtained from the formylation reactions of compounds (13) and (12). In addition, the synthesis strategies of thiazole compounds are outlined, with particular emphasis on product formation in formylation reactions. The measurement of antioxidant capacity plays an important role in the synthesis of bioactive heterocyclic compounds with therapeutic potential. Compound (17) (13.7% RSC) showed the best DPPH activity (Reference trolox 84 %). When the CUPRAC test was applied to compound (17), the TEAC value (Trolox equivalent antioxidant capacity) was found to be 1.75±0.018. The results reveal that compound (17) possesses poor radical scavenging ability while maintaining significant reducing strength.

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Cite This Article

Biçer, A., Sevinç, G. (2026). Determination of the antioxidant capacity of some thiazole derivatives using the CUPRAC and DPPH method. Avrupa Yaşam Bilimleri Dergisi, Volume: 5 Issue: 2. https://doi.org/10.55971/EJLS.1896819

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