Hence we are trying in this review to introduce most reports that evaluated the use of Niclosamide and Levamisole for treatment of patients infected with Covid 19 .We concluded that the encouraging studies regarding the repurpose of the two drugs may highlighting for further studies that can widening the options for existing treatment strategy used for patients with COVID-19.
📌 3 Key Takeaways
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Objective & Hypothesis:Since the world health organization declared the pandemic of covid 19, many drugs have been tested and re-evaluated to find effective treatment for the novel corona virus infection.
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Key Findings & Data:Niclosamide and Levamisole which are FDA approved anthelmintic drugs have been evaluated by many researchers and agencies to repurpose of these drugs as additional options for existing treatment strategy used for patients with Covid-19.
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Conclusion & Impact:Hence we are trying in this review to introduce most reports that evaluated the use of Niclosamide and Levamisole for treatment of patients infected with Covid 19 .We concluded that the encouraging studies regarding the repurpose of the two drugs may highlighting for further studies that can widening the options for existing treatment strategy used for patients with COVID-19.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Covid 19 · Levamisole · Niclosamide
Abstract
Since the world health organization declared the pandemic of covid 19, many drugs have been tested and re-evaluated to find effective treatment for the novel corona virus infection. Niclosamide and Levamisole which are FDA approved anthelmintic drugs have been evaluated by many researchers and agencies to repurpose of these drugs as additional options for existing treatment strategy used for patients with Covid-19. Hence we are trying in this review to introduce most reports that evaluated the use of Niclosamide and Levamisole for treatment of patients infected with Covid 19 .We concluded that the encouraging studies regarding the repurpose of the two drugs may highlighting for further studies that can widening the options for existing treatment strategy used for patients with COVID-19.
ABED, A. B., KORCAN, S. E. (2022). Evaluation the plausibility of pepurpose of levamisole and niclosamide in treatment of Covid-19. Journal of Pharmaceutical Technology, Cilt: 3 - Sayı: 1, 30–36. https://ajindex.com/articles/872828
WHO Expert Committee on the Selection, Use of Essential Medicines, World Health Organization. The selection and use of essential medicines. World Health Organization; 2008
Chen W, Mook RA, Premont RT, Wang J. Niclosamide: Beyond an antihelminthic drug. Cellular Signalling. 2018;41:89-96
Pindiprolu SH, Pindiprolu SKS. CD133 receptor mediated delivery of STAT3 inhibitor for simultaneous elimination of cancer cells and cancer stem cells in oral squamous cell carcinoma. Medical Hypotheses. 2019;129:109241
Pan J, Ding K, Wang C. Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells. Chin J Cancer. 2012;31(4):178-84
Presidente PJ, Worley DE. Efficacy of levo-tetramisole against experimental Dictyocaulusfilaria in lambs. American journal of veterinary research. 1969;30(9):1625-30
Gatti F, Krubwa F, Vandepitte J, Thienpont D. Control of intestinal nematodes in African schoolchildren by the trimestrial administration of levamisole. Ann SocBelg Med Trop. 1972;52(1):19-31
Thienpont D. Tetramisole (R 8299), a new, potent broad spectrum anthelmintic. Nature. 1966;209:1084-6
Thienpont D, Brugmans J, Abadi K, Tanamal S. Tetramisole in the treatment of nematode infections in man. The American journal of tropical medicine and hygiene. 1969;18(4):520-5
Lee KC, Ladizinski B, Federman DG. Complications Associated With Use of Levamisole-Contaminated Cocaine: An Emerging Public Health Challenge. Mayo Clinic Proceedings. 2012;87(6):581-6
Scheinfeld N, Rosenberg JD, Weinberg JM. Levamisole in Dermatology. American Journal of Clinical Dermatology. 2004;5(2):97-104
U.S. Food and Drug Administration. FDA approval: Levamisole
Yin J, Jin H, Yang F, et al. Synergistic effects of adjuvants interferon-gamma and levamisole on DNA vaccination against infection with Newcastle disease virus. Viral Immunol. 2007;20(2):288-99
Singh KCP, Dhawedkar RG. Immunomodulating effects of levamisole in chicks immunocompromised by infectious bursal disease virus. Trop Anim Health Prod. 1993;25(1):11-4
Giambrone JJ, Klesius PH. Effect of levamisole on the response of broilers to coccidiosis vaccination. Poult Sci. 1985;64(6):1083-9
Weinbach EC, GARBUS J. Mechanism of action of reagents that uncouple oxidative phosphorylation. Nature. 1969 Mar;221(5185):101