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Journals / Middle East Journal of Science / 2022 / Cilt: 8 - Sayı: 2

SEVERE PRE-ECLAMPSIA COMPLICATED BY HELLP SYNDROME IN THE HOFFBAUER AND SYNCYTIOTROPHOBLAST CELLS (ULTRASTRUCTURAL AND IMMUNOHISTOCHEMICAL STUDY)

Yusuf NERGİZ
Şebnem NERGİZ ÖZTÜRK
Fırat AŞIR
Engin DEVECİ
Muhammet Erdal SAK
Mehmet Sıddık EVSEN
Selcuk TUNİK
Uğur ŞEKER
Pages
91–98
Publication Date
2022-12-31
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The increase in the number of Hoffbauer cells per villus in the HELLP group was statistically significant (p

📌 3 Key Takeaways

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Objective & Hypothesis:The aim of this study was to evaluate the immunohistochemistry and ultrastructural of syncytiotrophoblast and Hoffbauer cells in placental villi of HELLP syndrome patients.
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Key Findings & Data:Placental samples with twenty control (normotensive) and twenty HELLP syndrome were fixed in 10% neutral formalin solution for paraffin-embedding wax protocol.
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Conclusion & Impact:The increase in the number of Hoffbauer cells per villus in the HELLP group was statistically significant (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:HELLP · Hoffbauer cell · syncytiotrophoblast

Abstract

The aim of this study was to evaluate the immunohistochemistry and ultrastructural of syncytiotrophoblast and Hoffbauer cells in placental villi of HELLP syndrome patients. Placental samples with twenty control (normotensive) and twenty HELLP syndrome were fixed in 10% neutral formalin solution for paraffin-embedding wax protocol. Placental samples were fixed in 2.5% buffered glutaraldehyde and then, in 1% osmium tetra oxide for routine electron microscopic procedure. When the HELLP group fetal placental sections were examined, intracytoplasmic edema in syncytiotrophoblast, degenerative vacuoles and degenerative findings on cell surface membranes were observed. Moreover, villous edema was remarkable. The number of CD68 positive Hoffbauer cells per villus control group sections was 0.23 ± 0.02 and the number of CD68 positive cells per villus in HELLP group placenta sections was 0.83 ± 0.12 . The increase in the number of Hoffbauer cells per villus in the HELLP group was statistically significant (p

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Cite This Article

NERGİZ, Y., ÖZTÜRK, Ş. N., AŞIR, F., DEVECİ, E., SAK, M. E., EVSEN, M. S., TUNİK, S., ŞEKER, U. (2022). SEVERE PRE-ECLAMPSIA COMPLICATED BY HELLP SYNDROME IN THE HOFFBAUER AND SYNCYTIOTROPHOBLAST CELLS (ULTRASTRUCTURAL AND IMMUNOHISTOCHEMICAL STUDY). Middle East Journal of Science, Cilt: 8 - Sayı: 2, 91–98. https://ajindex.com/articles/861923

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