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Journals / Clinical and Experimental Health Sciences / 2022 / Cilt: 12 - Sayı: 4

Proteomic Analysis in Nifedipine Induced Gingival Overgrowth: A Pilot Study

Ece YETİŞ
Ayşen YARAT
Onur EROĞLU
Hafize ÖZTÜRK ÖZENER
Leyla KURU
Pages
1013–1024
Publication Date
2022-12-30
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

Results: Bleeding on probing and gingival overgrowth index of the GO+ group were statistically significantly higher than the GO- group (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aims of the present study were to investigate the proteomic profile of nifedipine induced overgrown gingiva and compare with non-overgrown gingival tissues obtained from the same patients.
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Key Findings & Data:Methods: Seven subjects under nifedipine medication for at least 6 months and diagnosed as nifedipine induced gingival overgrowth (NIGO) participated in the study.
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Conclusion & Impact:Results: Bleeding on probing and gingival overgrowth index of the GO+ group were statistically significantly higher than the GO- group (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:gingival overgrowth · nifedipine · proteomics

Abstract

Objective: The aims of the present study were to investigate the proteomic profile of nifedipine induced overgrown gingiva and compare with non-overgrown gingival tissues obtained from the same patients. Methods: Seven subjects under nifedipine medication for at least 6 months and diagnosed as nifedipine induced gingival overgrowth (NIGO) participated in the study. Periodontal clinical parameters were recorded. Gingival tissue samples were harvested from overgrown (GO+ Group, n=7) and non-overgrown regions (GO- Group, n=7) of the same patients. Proteomics was performed using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) technique. The identified proteins were further classified according to their molecular functions, biological processes and cellular component distribution for functional gene ontology analysis using a web-based bioinformatics tool. Mann Whitney-U and ANOVA tests were performed to compare clinical parameters and identified proteins with proteomics, respectively. Results: Bleeding on probing and gingival overgrowth index of the GO+ group were statistically significantly higher than the GO- group (p

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Cite This Article

YETİŞ, E., YARAT, A., EROĞLU, O., ÖZENER, H. Ö., KURU, L. (2022). Proteomic Analysis in Nifedipine Induced Gingival Overgrowth: A Pilot Study. Clinical and Experimental Health Sciences, Cilt: 12 - Sayı: 4, 1013–1024. https://ajindex.com/articles/858371

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