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Journals / Bilecik Şeyh Edebali Üniversitesi Fen Bilimleri Dergisi / 2022 / Cilt: 9 - Sayı: 2

In vitro Antiradical, Antimicrobial, Anticancer, and Phytochemical Properties of Rumex acetosella L. (Sorrel)

Rumex acetosella L. (Kuzukulağı)’nın In vitro Antiradikal, Antimikrobiyal, Antikanser ve Fitokimyasal Özellikleri

Fatma KESER
Mustafa KARATEPE
Serhat KESER
Suat TEKİN
İsmail TÜRKOĞLU
Omer KAYGILI
Ersin DEMİR
Prof. Dr. Ökkeş YILMAZ
Süleyman SANDAL
Sevda KIRBAĞ
Pages
683–692
Publication Date
2022-12-31
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Also the presented study is the first study on the in vitro anticancer activity of R. acetosella extracts.

📌 3 Key Takeaways

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Objective & Hypothesis:R. acetosella is a perennial herbaceous plant in the Polygonaceae family and is consumed as a vegetable among the people in Turkey.
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Key Findings & Data:In this study, antimicrobial (Escherichia coli, Bacillus megaterium, Bacillus subtilis, Proteus vulgaris, Pseudomonas aeruginosa, Listeria monocytogenes, Klebsiella pneumoniae, Staphylococcus aureus bacteria and Candida albicans yeast-fungi), antiradical (against to DPPH, ABTS and OH radicals), anticancer (against to human prostate cancer (PC-3), human colon cancer (HCT-116), human ovarian cancer (A2780) and human breast cancer (MCF-7) cell lines) and phytochemical properties (lipid-soluble vitamins, fatty acids, flavonoids, phenolic acids, phytosterols, total phenolic compounds, total flavonoid, and total proanthocyanidins) of ethanol, water and methanol extracts of R. acetosella aerial parts were investigated.
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Conclusion & Impact:Also the presented study is the first study on the in vitro anticancer activity of R. acetosella extracts.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:R. acetosella · Kuzukulağı · Antiradikal

Abstract

R. acetosella is a perennial herbaceous plant in the Polygonaceae family and is consumed as a vegetable among the people in Turkey. In this study, antimicrobial (Escherichia coli, Bacillus megaterium, Bacillus subtilis, Proteus vulgaris, Pseudomonas aeruginosa, Listeria monocytogenes, Klebsiella pneumoniae, Staphylococcus aureus bacteria and Candida albicans yeast-fungi), antiradical (against to DPPH, ABTS and OH radicals), anticancer (against to human prostate cancer (PC-3), human colon cancer (HCT-116), human ovarian cancer (A2780) and human breast cancer (MCF-7) cell lines) and phytochemical properties (lipid-soluble vitamins, fatty acids, flavonoids, phenolic acids, phytosterols, total phenolic compounds, total flavonoid, and total proanthocyanidins) of ethanol, water and methanol extracts of R. acetosella aerial parts were investigated. According to our results, it was determined that R. acetosella extracts have higher activity than the BHT in scavenging tests of ABTS, DPPH and OH radicals. It has also been understood that this plant has high antimicrobial activity and phytochemical content and effective anticancer activities against to PC-3 human prostate cancer cell lines. Also the presented study is the first study on the in vitro anticancer activity of R. acetosella extracts.

Özet

Polygonaceae familyasında yer alan R. acetosella, çok yıllık otsu bir bitkidir ve Türkiye’de halk arasında sebze olarak tüketilmektedir. Bu çalışmada R. acetosella toprak üst kısımlarının etanol, su ve metanol ekstraktlarının antimikrobiyal (Escherichia coli, Bacillus megaterium, Bacillus subtilis, Proteus vulgaris, Pseudomonas aeruginosa, Listeria monocytogenes, Klebsiella pneumoniae, Staphylococcus aureus bakterileri ve Candida albicansmaya-mantarına karşı), antiradikal (DPPH, ABTS ve OH radikallerine karşı), antikanser (insan prostat kanseri (PC-3), insan kolon kanseri (HCT-116), insan yumurtalık kanseri (A2780) ve insan göğüs kanseri (MCF-7) hücre serilerine karşı) ve fitokimyasal özellikleri (yağda çözünen vitaminler, yağ asitleri, flavonoitler, fitosteroller, fenolik asitler, toplam fenolik bileşik, toplam flavonoit ve toplam proantosiyanidinler) incelenmiştir. Sonuçlarımıza göre R. acetosella ekstraktlarının ABTS, DPPH ve OH radikali yok etme testlerinde BHT’den daha yüksek aktiviteye sahip oldukları belirlenmiştir. Ayrıca bu bitkinin yüksek antimikrobiyal aktiviteye ve fitokimyasal içeriğe sahip olduğu, PC-3 insan prostat kanseri hücrelerine karşı etkili antikanser aktivite gösterdiği anlaşılmıştır. Aynı zamanda sunulan çalışma, R. acetosella ekstraktlarının in vitro antikanser aktivitesi ile ilgili ilk çalışma olma özelliği taşımaktadır.

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Cite This Article

KESER, F., KARATEPE, M., KESER, S., TEKİN, S., TÜRKOĞLU, İ., KAYGILI, O., DEMİR, E., YILMAZ, P. D. Ö., SANDAL, S., KIRBAĞ, S. (2022). In vitro Antiradical, Antimicrobial, Anticancer, and Phytochemical Properties of Rumex acetosella L. (Sorrel). Bilecik Şeyh Edebali Üniversitesi Fen Bilimleri Dergisi, Cilt: 9 - Sayı: 2, 683–692. https://ajindex.com/articles/858069

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