Journals / Batı Karadeniz Tıp Dergisi / 2022 / Cilt: 6 - Sayı: 3

Predictive Value of Fragmented QRS Complex Over One Year Mortality Among Ticagrelor Loaded Acute Coronary Syndrome Patients

Tikagrelor Yüklemesi Yapılan Akut Koroner Sendrom Hastalarında Fragmante QRS Kompleksinin Bir Yıllık Mortalitedeki Prediktif Değeri

Pages
366–372
Publication Date
2022-12-27
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: A total of 498 (STEMI 324, 65,1%; NONSTEMI 174, 34,9%) patients with acute myocardial infarction who were loaded with ticagrelor and underwent invasive intervention, 272(%54,6) in the fQRS group and 226 (45.4%) in the non-fQRS group, were included in the study.Patients without fQRS had a family history of heart disease (85, 37.4%), NSTEMI (119, 52.4%), systolic blood pressure (125.16±25.03 mmHg) were significantly higher than those with fQRS (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Various factors and risk classifications have been proposed to determine the prognosis in patients with acute myocardial infarction.
📊
Key Findings & Data:Fragmented QRS (fQRS) encompasses different RSR' patterns showing various morphologies of QRS complexes with or without Q waves on a 12-lead resting electrocardiogram (ECG). fQRS is a marker of myocardial scarring and is associated with prognosis.
💡
Conclusion & Impact:Results: A total of 498 (STEMI 324, 65,1%; NONSTEMI 174, 34,9%) patients with acute myocardial infarction who were loaded with ticagrelor and underwent invasive intervention, 272(%54,6) in the fQRS group and 226 (45.4%) in the non-fQRS group, were included in the study.Patients without fQRS had a family history of heart disease (85, 37.4%), NSTEMI (119, 52.4%), systolic blood pressure (125.16±25.03 mmHg) were significantly higher than those with fQRS (p
🔬Design:Research Article
📍Scope:2018 Verileri
⚙️Variables:Akut koroner sendrom · elektrokardiyografi · fragmente QRS

Abstract

Aim: Various factors and risk classifications have been proposed to determine the prognosis in patients with acute myocardial infarction. Fragmented QRS (fQRS) encompasses different RSR' patterns showing various morphologies of QRS complexes with or without Q waves on a 12-lead resting electrocardiogram (ECG). fQRS is a marker of myocardial scarring and is associated with prognosis. It has been shown to cause adverse cardiac outcomes when seen in certain cardiovascular diseases, including coronary artery disease. The need for risk stratification continues for the most effective and appropriate treatment of patients presenting with acute myocardial infarction. In this study, we aimed to investigate the effect of the presence of fQRS on the ECG in determining the prognosis in patients with acute myocardial infarction who underwent invasive intervention with ticagrelor loading. Material and Methods: All acute myocardial infarction patients who applied to Zonguldak Bulent Ecevit University Health, Application and Research Center between January 2018 and January 2020 with acute coronary syndrome and underwent ticagrelor challenge and invasive intervention were retrospectively screened and included in the study. Demographic information (age, gender), cardiovascular history, risk factors and chronic diseases of 498 patients included in the study were obtained from medical records. Patients were divided into two groups according to the presence of fQRS in the application electrocardiogram. Pre-discharge mortality data of patients were obtained from medical records. The one-year follow-up was obtained by interviewing them, their families, or their personal physicians (directly or by telephone). Results: A total of 498 (STEMI 324, 65,1%; NONSTEMI 174, 34,9%) patients with acute myocardial infarction who were loaded with ticagrelor and underwent invasive intervention, 272(%54,6) in the fQRS group and 226 (45.4%) in the non-fQRS group, were included in the study.Patients without fQRS had a family history of heart disease (85, 37.4%), NSTEMI (119, 52.4%), systolic blood pressure (125.16±25.03 mmHg) were significantly higher than those with fQRS (p

Özet

Amaç: Akut miyokart infarktüsü hastalarında prognozunu belirlemek için çeşitli faktörler ve risk sınıflandırmaları önerilmiştir. Fragmente QRS (fQRS), 12 derivasyonlu istirahat elektrokardiyogramda (EKG) Q dalgası olan veya olmayan QRS komplekslerinin çeşitli morfolojilerini gösteren farklı RSR' modellerini kapsar. fQRS, miyokard skarının bir belirtecidir ve prognoz ile ilişkilidir. Koroner arter hastalığı da dahil olmak üzere bazı kadiyovasküler hastalıklarda görüldüğünde olumsuz kardiyak sonuçlara neden olabileceği gösterilmiştir. Akut miyokart infarktüsü ile başvuran hastaların en etkili ve uygun şekilde tedavi edilebilmesi için risk sınıflandırmasına duyulan ihtiyaç devam etmektedir.Bu çalışmada tikagrelor yüklemesi invaziv girişim yapılan akut miyokart infarktüsü hastalarında EKG’de görülen fQRS varlığının prognozu belirlemedeki etkisini araştırmayı amaçladık. Gereç ve Yöntemler: Ocak 2018 ile Ocak 2020 tarihleri arasında Zonguldak Bülent Ecevit Üniversitesi Sağlık, Uygulama ve Araştırma Merkezi’ne akut koroner sendrom ile başvuran ve tikagrelor yüklemesi ve invaziv girişim yapılmış bütün akut miyokart infarktüsü hastaları retrospektif olarak taranarak çalışmaya dahil edildi. Çalışmaya dahil edilen 498 hastanın demografik bilgileri (yaş, cinsiyet), kardiyovasküler öyküleri, risk faktörleri ve kronik hastalıkları tıbbi kayıtlardan elde edildi. Başvuru elektrokardiyogramında fQRS varlığına göre hastalar iki gruba ayrıldı. Hastaların hastanedeki taburculuk öncesi mortalite verileri tıbbi kayıtlardan elde edildi. Bir yıllık takipleri ise kendileriyle, aileleriyle veya kişisel doktorlarıyla (doğrudan ya da telefon ile) görüşülerek elde edildi. Bulgular: Çalışmaya fQRS grubunda 272 (%54,6) ve fQRS olmayan grupta 226 (%45,4) olmak üzere toplam 498 tikagrelor yüklenen ve invaziv girişim yapılmış akut miyokart infarktüsü hastası (STEMI 324, %65,1; NONSTEMI 174, %34,9) dahil edildi. fQRS olmayan hastalarda ailede kalp hastalığı öyküsü (85, %37.4), NONSTEMI (119, %52.4), sistolik kan basıncı (125.16±25.03 mmHg) fQRS olanlara kıyasla anlamlı olarak daha yüksekti (tüm karşılaştırmalar için p

🔖

Cite This Article

GÜDÜL, N. E., KARA, S., KOÇ, S., HAMZA, Y., DANLI, E. N., ÇELEBİ, B., ALKAN, O., KARABULUT, C., ARSLANTÜRK, Ö. F., NAHIRCI, S. S., DEMİR, D., DEMİR, G., PİYADE, F. E., KARAKAŞ, Ü., ALTIN, V. (2022). Predictive Value of Fragmented QRS Complex Over One Year Mortality Among Ticagrelor Loaded Acute Coronary Syndrome Patients. Batı Karadeniz Tıp Dergisi, Cilt: 6 - Sayı: 3, 366–372. https://ajindex.com/articles/857621

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Roth GA, Johnson C, Abajobir A, Abd-Allah F, Abera SF, Abyu G et al. Global, regional, and national burden of cardiovascular diseases for 10 causes,1990 to 2015. J Am Coll Cardiol 2017 Jul 4
  2. 70(1):1-25. 2-Antman EM, Cohen M, Bernink PJ, McCabe CH, Horacek T, Papuchis G et al. The TIMI risk score for unstable angina/non–ST elevation MI: a method for prognostication and therapeutic decision making. JAMA 2000 Aug 16
  3. 284(7):835–842. 3-Aragam KG, Tamhane UU, Kline-Rogers E, Li J, Fox KA, Goodman SG et al. Does simplicity compromise accuracy in ACS risk prediction? A retrospective analysis of the TIMI and GRACE risk scores. Plos One 2009 Nov 23
  4. 4(11):e7947. 4-Omidi N, Sharif Kashani B, Asadpour Piranfar M, Khorgami MR, Ghorbani Yekta B, Omidi H. The correlation of diastolic dysfunction with TIMI frame count in patientswith chronic stable angina pectoris. Tehran Univ Med J 2012
  5. 70(9): 555–563. 5-Malakar AK, Choudhury D, Halder B, Paul P, Uddin A, Chakraborty S. A review on coronary artery disease, its risk factors, and therapeutics. J Cell Physiol. 2019 Aug
  6. 234(10):16812-16823. 6-Taylor GJ, Humphries JO, Mellits ED, et al. Predictors of clinical course, coronary anatomy and left ventricular function after recovery from acute myocardial infarction. Circulation. 1980 Nov
  7. 62(5): 960-970. 7-Weintraub WS, Taggart DP, Mancini GBJ, Brown DL, Boden WE. Historica lMilestones in the management of stable coronary artery disease over the last half century. Am J Med. 2018 Nov
  8. 131(11): 1285-1292. 8-Adabag AS, Therneau TM, Gersh BJ, et al. Sudden death after myocardial infarction. JAMA 2008 Nov
  9. 300(17): 2022-2029. 9-Moss AJ, Hall WJ, Cannom DS, et al. Improved survival with an implanted defibrillator in patients with coronary disease at high risk for ventricular arrhythmia. Multicenter Automatic Defibrillator Implantation Trial Investigators. N Engl J Med. 1996 Dec
  10. 335(26): 1933-1940. 10-Take Y, Morita H. Fragmented QRS: what is the meaning? Indian Pacing Electrophysiol J 2012 Sep
  11. 12(5):213–225. 11-Uyarel H, Cam N, Okmen E, Kasıkcıoglu H, Tartan Z, Akgul O et al. Level of Selvester QRS score is predictive of ST-segment resolution and 30-day outcomes in patients with acute myocardial infarction undergoing primary coronary intervention. Am Heart J 2006 Jun
  12. 151(6):1239.e1-7. 12-Coşkun A, Eren SH. R/S ratio in lead II, and the prognostic significance of red cell distribution width in acute coronary syndrome. World J Clin Cases 2019 Aug 26
  13. 7(16):2217-2226. 13-Jose F, Kr