SavedAdd your journal

Journals / Journal of Pharmaceutical Technology / 2020 / Cilt: 1 - Sayı: 1

An update on cyclodextrins as drug vehicles for antimicrobial applications

Ece ÖZCAN BÜLBÜL
Kalliopi ELEFTHERIADOU
Neslihan ÜSTÜNDAĞ OKUR
Panoraia SİAFAKA
Pages
18–24
Publication Date
2020-04-01
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Regarding this, the most recent cyclodextrin inclusion complexes with antimicrobial and antifungal drugs are summarized in this article.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Cyclodextrins belong to cyclic oligosaccharides comprised of α-(1,4) linked glucopyranose groups.
📊
Key Findings & Data:Their interesting supramolecular cavity-like structure can host active molecules providing a breeding ground for drug delivery systems.
💡
Conclusion & Impact:Regarding this, the most recent cyclodextrin inclusion complexes with antimicrobial and antifungal drugs are summarized in this article.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Antibacterial · Antifungal · Cyclodextrins

Abstract

Cyclodextrins belong to cyclic oligosaccharides comprised of α-(1,4) linked glucopyranose groups. Their interesting supramolecular cavity-like structure can host active molecules providing a breeding ground for drug delivery systems. Cyclodextrins, due to their unique functional structure, can produce host-guest complexes with active ingredients, such as drugs, peptides, proteins, etc.; the complexes resulted from intramolecular interactions leading to stable molecules vehicles. Moreover, cyclodextrins are already applied in pharmaceutical industry applications since they can induce the solubility of lipophilic compounds and provide bioavailability and excellent safety profile and stability. In this review, the basic background for cyclodextrins and their current applications in the antimicrobial field are discussed. Besides, the antibacterial and antifungal-applications in the pharmaceutical field attract most researchers because of microbes’ resistance. Regarding this, the most recent cyclodextrin inclusion complexes with antimicrobial and antifungal drugs are summarized in this article.

🔖

Cite This Article

BÜLBÜL, E. Ö., ELEFTHERIADOU, K., OKUR, N. Ü., SİAFAKA, P. (2020). An update on cyclodextrins as drug vehicles for antimicrobial applications. Journal of Pharmaceutical Technology, Cilt: 1 - Sayı: 1, 18–24. https://ajindex.com/articles/836565

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (10)

  1. Cid AG, Simonazzi A, Palma SD, Bermúdez JM. Solid dispersion technology as a strategy to improve the bioavailability of poorly soluble drugs. Ther Deliv. (2019); 10: 363-382.
  2. Siafaka P, Üstündağ Okur N, Mone M, Giannakopoulou S, Er S, Pavlidou E, Karavas E, Bikiaris D. Two different approaches for oral administration of voriconazole loaded formulations: electrospun fibers versus β-cyclodextrin complexes. Int J Mol Sci. (2016) 17(3): 282.
  3. Schittny A, Huwyler J, Puchkov M. Mechanisms of increased bioavailability through amorphous solid dispersions: a review. Drug Deliv. (2020); 27(1): 110-127.
  4. Nabekura T, Ito Y, Cai H, Terao M, Hori R. Preparation and in vivo ocular absorption studies of disulfiram solid dispersion. Biol Pharm Bull. (2000); 23(5): 616-620.
  5. Karagianni A, Kachrimanis K, Nikolakakis I, Co-Amorphous solid dispersions for solubility and absorption improvement of drugs: composition, preparation, characterization and formulations for oral delivery. Pharmaceutics. (2018); 10(3): 98.
  6. Üstündağ Okur N, Filippousi M, Okur ME, Ayla Ş, Çağlar EŞ, Yoltaş A, Siafaka PI. A novel approach for skin infections: controlled release topical mats of poly(lactic acid)/poly(ethylene succinate) blends containing Voriconazole. J Drug Deliv Sci Technol. (2018); 46: 74- 86.
  7. Özcan Bülbül E, Mesut B, Cevher E, Öztaş E, Özsoy Y. Product transfer from lab-scale to pilot-scale of quetiapine fumarate orodispersible films using quality by design approach. J Drug Deliv Sci Technol. (2019); 54: 101358.
  8. Siafaka PI, Barmbalexis P, Bikiaris DN, Novel electrospun nanofibrous matrices prepared from poly(lactic acid)/poly(butylene adipate) blends for controlled release formulations of an anti- rheumatoid agent. Eur J Pharm Sci. (2016); 88: 12-25.
  9. Mahmah O, Tabbakh R, Kelly A, Paradkar A. A comparative study of the effect of spray drying and hot-melt extrusion on the properties of amorphous solid dispersions containing felodipine. J Pharm Pharmacol. (2014); 66(2): 275-284.
  10. Dhillon B, Goyal NK, Sharma PK. Formulation and evaluation of glibenclamide solid dispersion using different metho