Journals / Van Sağlık Bilimleri Dergisi / 2018 / Cilt: 11 - Sayı: 2

Serum vitamin C, Beta-carotene and retinol levels in liver and gastrointestinal systems diseases

KARACİĞER VE GASTROİNTESTİNAL SİSTEM HASTALIKLARINDA SER UM C VİTAMİNİ, Beta -KAROTEN VE RETİNOL DÜZEYLERİ

Pages
6–10
Publication Date
2018-12-15
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

For this purpose, diets rich in antioxidant vitamins can play a protective role in the prevention and progression of these diseases.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Gastrointestinal system diseases are important causes of morbidity and mortality worldwide.
📊
Key Findings & Data:In this study, vitamin C, b- carotene and retinol levels were evaluated in the serum of 35 ulcers, 40 esophageal cancer, 30 gastric cancer, 25 liver cirrhosis patients and 50 healthy individuals.
💡
Conclusion & Impact:For this purpose, diets rich in antioxidant vitamins can play a protective role in the prevention and progression of these diseases.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Beta-karoten · gastroindestinal kanser · siroz

Abstract

Gastrointestinal system diseases are important causes of morbidity and mortality worldwide. Vita min C, b-carotene and retinol, which have antioxidant properties, play an important role in the prevention of lipid peroxidation and free radical development in diseases of the gastrointestinal tract and cancers. The aim of this study was to evaluate the relationship between serum levels of vitamin C, b-carotene and retinol with ulcers, cirrhosis, esophagus and stomach cancer diseases. In this study, vitamin C, b- carotene and retinol levels were evaluated in the serum of 35 ulcers, 40 esophageal cancer, 30 gastric cancer, 25 liver cirrhosis patients and 50 healthy individuals. Vita mins were analyzed spectrophotometrically. Comparison of serum vitamin C levels of the patient groups with the control group, shows a statistically significant decrease in ulcerative patients and increase in esophageal cancer patients (p<0.05). No statistically significant difference was found in vitamin C levels in patients with gastric cancer and cirrhosis (p>0.05). b-carotene and retinol levels were high in patients with ulcers, lower in patients with esophagus and cirrhosis (p<0.05). Serum b-carotene and retinol levels were not statistically significant in patients with gastric cancer (p>0.05). b-carotene and retinol decreased significantly in the esophagus-stomach cancers and liver cirrhosis whereas an increase in vitamin C was observed. We believe that our research will provide useful information for incorporating antioxidant agents into the diet. For this purpose, diets rich in antioxidant vitamins can play a protective role in the prevention and progression of these diseases.

Özet

Gastroindestinal sistem hastalıkları dünya çapında önemli morbitide ve mortalite nedenleridir. Antioksidan özelliğe sahip vitamin C, b- karoten ve retinol, gastrointestinal sistem hastalıkla rı ve kanserle rde lipid peroksidasyonu ve serbest radikal gelişiminin önlenmesinde önemli role sahiptir. Bu ça lış manın amac ı, antioksidan özelliğe sahip vitamin C, b-karoten ve retinolün serum düzeyleriyle ülser, siroz, özefagus ve mide kanser hastalıkları arasındaki ilişkiyi değerlendirmektir. Çalışmada 35 ülserli, 40 özefagus kanserli, 30 mide kanserli, 25 karac iğer siro zlu hasta ile 50 sağlıklı birey serumlarında, C vitamini, b-karoten ve retinol düzeyleri değerlendirildi. Vitaminler spektrofotometrik olarak analiz edildi. Hasta gruplarının serum C vitamini düzeylerinin kontrol grubu ile karşılaştırılmasında, ülserli hastalarda azalma ve özofagus kanserli hastalarda artış istatistiksel olara k an la mlıydı (p<0.05). Mide kanseri ve sirozlu hasta vitamin C düzeylerinde istatistik olara k bir fark bulunamadı (p>0.05). b-karoten ve retinol düzeyleri, ülserli hastalarda yüksek, özefagus ve sirozlu hastalarda düşük olarak saptandı (p<0.05). Mide kanserli hastalarda serum b- karoten ve retinol düzeylerinde istatistik anlam yoktu (p>0.05). Özefagus-mide kanserlerinde ve karaciğer sirozunda b-karoten ve retinol önemli oranda azaldı, C vitamini ise yükseldi. Sonuç olarak bu çalışmadan elde edilen verilerin antioksidan ajanların diyette yer almasının bu hastalıkla rın önlen mesi ve ilerle mesin in durdurulmasında koruyucu rol üstlenebileceğine dair açısından yararlı bilg iler sunacağı kanaatine varıld ı.

🔖

Cite This Article

KAHRAMAN, T., BERKÖZ, M., ÜSTÜN, R., TÜRKDOĞAN, M. K. (2018). Serum vitamin C, Beta-carotene and retinol levels in liver and gastrointestinal systems diseases. Van Sağlık Bilimleri Dergisi, Cilt: 11 - Sayı: 2, 6–10. https://ajindex.com/articles/821539

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (9)

  1. Abnet CC, Qiao YL, Davsey SM, Buckman DW, Yang CS, Blot WJ, et al. Prospective study of serum retinol, beta-carotene, betacryptoxanthin, and lutein/z eaxant hin and esophageal and gastr ic cancers in China. Canc er Causes Control 2003; 14(7):645- 55. Aditi A, and Gr aham DY. Vitamin C, gastr itis, and gastric disease: A historical review and update. Dig Dis Sci 2012; 57(10):2504-15. Akkuş İ. Serbest Radikaller ve Fizyopatolojik Etkileri. Kony a, Mimoza Yayınl arı,1995.
  2. Alcant ara EN, Speckmann EW. Diet, nutrition, and cancer. Am J Clin Nutr 1976;29: 1035-47.
  3. Almushatat AS, Tavlar D, McArdle PA, Williamson C, Sattar N, O’r eil ly DS, et al. Vitamin antio xidant, lipid peroxidat ion and the systemic inflammatory response in patients with prostate cancer. Int J Cancer 2005;118(4),1051-3.
  4. Azevedo LF, Salgueiro LF, Claro R, Teixeir a-Pinto A, Costa- Pereira A. Diet and gastric cancer in Portugal-a multiv ariate model. Eur J Cancer Prev 1999;8(1):41- 8. Bollag W, Holdener EE. Retinoids in cancer prev ention and therapy. Ann Oncol. 1992; 3(7):513-26.
  5. Chamras H, B arsky SH, Ardashian A, Nav asartian D, H eber D, Glaspy JA. Nov el interact ions of vit amin-E and estrogen in breast cancer. Nutr Cancer 2005;52(1), 43–8.
  6. Dündar Y, Aslan R. H ekimlikte Oksidatif Stres ve Antioksidanlar, Afyon. Afyon Kocatepe Üniversit esi Yayınl arı, 2000.
  7. Dursun H, Bilici M, Uyanık A, Okcu N, Akyüz M. Antioxidant enzyme activities and lipid peroxidatio n lev els in erythrocytes of patients with oesophageal and gastric canc er. J I nter Med Res 2006; 34: 193-9.
  8. Fu Y, Yang G, Zhu F, Peng C, Li W, Li H, et al. Antioxidants decrease the apoptotic effect of 5-Fu in colon cancer by regulat ing Src-dep endent caspas e-7 phosphorylation. Cell Death Dis. 2014; 5(1):983. Goodman GE, Alberts DS, Meyskens FL. Retinol, vitamins, and canc er prev ention: 25 years of l earning and r el ear ning. J Clin Oncol 2008;26: 5495-6. Halliw ell B. Antioxidants and human disease: A gener al introduct ion. Nutr Rev 1997;55: 44-52.
  9. Ito Y, Kurata M, Hioki R, Suzuki K, Ochiai J, Aoki K. Cancer mortality and s erum levels of carotenoids, r etino l, and tokopherol: A population-based follow-up study of inhabit ants of a rur al area of Japan. Asian Pac J Cancer Prev 2005;6(1):10- 5. Jenab M, Salvini S, Gils CHV, Brustad M, Shaky a-Shrestha S, Buijsse B, et al. Dietary intakes of r etinol, -carotene, vitamin D and vitamin E in the European Prospective investigatio n into Cancer and Nutrit ion cohort. Eur J Clin Nu