SavedAdd your journal

Journals / International Journal of Traditional and Complementary Medicine Research / 2025 / Volume: 6 Issue: 3

The Effects of Hyperı̇cum perforatum (St. John's Wort) Oil on Wound Healing and Comparison with Those of Collagenase Drugs

İbrahim Kahraman(Şırnak State Hospital)0000-0001-5081-5820
Ufuk Memiş(ERZINCAN BINALI YILDIRIM UNIVERSITY)0000-0003-3393-3301
Alparslan Koç(ERZINCAN BINALI YILDIRIM UNIVERSITY)0000-0002-5965-9761
Mehmet Tahir Huyut(ERZINCAN BINALI YILDIRIM UNIVERSITY)0000-0002-2564-991X
Mahir Tayfur(ERZINCAN BINALI YILDIRIM UNIVERSITY)0000-0001-7137-5465
Pages
—
Publication Date
2025-12-26
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusions: In conclusion, St.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background and Objectives: Wound healing is among the most fundamental problems in the field of health.
📊
Key Findings & Data:Materials and Methods: A total of 32 male Wistar rats of similar were used for the experiment.
💡
Conclusion & Impact:Conclusions: In conclusion, St.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Wound healing · incision wound · St. John

Abstract

Background and Objectives: Wound healing is among the most fundamental problems in the field of health. Oil of Hypericum perforatum (HP) has been used for various ailments, particularly depression, burns, and wound healing, globally for a long period of time. We investigated the healing-promoting effect of HP oil on wound healing histopathologically and macroscopically in an experimental wound model in rats, aiming to compare the results with those of collagenase pomade, which is actively used in the literature. Materials and Methods: A total of 32 male Wistar rats of similar were used for the experiment. The animals were randomly divided into four groups, each consisting of eight rats. After the dorsal areas of the rats were shaved and disinfected with povidone-iodine solution, a 1 cm2 full-thickness wound was created on the backs of each rat. The sham (control) group received dry gauze dressings, while the physiological saline (PS) group was treated with saline-soaked gauze. The collagenase ointment pomade (CP) group and HP groups were treated with gauze impregnated with 0.1 grams of these substances. All wounds were dressed twice daily, in the morning and evening. The second group was treated with physiological saline. The third group was treated with collagenase ointment. And the fourth group was treated with St. John's Wort oil. Wound areas were measured on days 3, 7, 10, 14, and 21. In addition, histopathological evaluation was performed on tissue samples obtained on day 14, and the day of complete wound closure was recorded for each animal. Results: When the findings were statistically analyzed, wounds treated with St. John's Wort oil and collagenase ointment healed significantly faster than the other groups (p < 0.05). Conclusions: In conclusion, St. John’s Wort oil appears to be a promising topical agent for enhancing wound healing, as it accelerates the healing process. However, controlled clinical trials in human subjects would provide the most definitive evidence on this topic.

🔖

Cite This Article

Kahraman, İ., Memiş, U., Koç, A., Huyut, M. T., Tayfur, M. (2025). The Effects of Hyperı̇cum perforatum (St. John's Wort) Oil on Wound Healing and Comparison with Those of Collagenase Drugs. International Journal of Traditional and Complementary Medicine Research, Volume: 6 Issue: 3. https://doi.org/10.53811/ijtcmr.1730565

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (37)

  1. Lazarus GS, Cooper DM, Knighton DR, et al. Definitions and guidelines for assessment of wounds and evaluation of healing. Arch Dermatol. 1994;130(4):489-493.
  2. Townsend CM, Beauchamp RD, Evers BM, Mattox KL. Sabiston Textbook of Surgery: The Biological Basis of Modern Surgical Practice. 20th ed. Elsevier Health Sciences; 2016.
  3. Rajendran S, Anand S. Hi-tech textiles for interactive wound therapies. In: Bartels VT, ed. Handbook of Medical Textiles. Woodhead Publishing; 2011:38-79.
  4. Jørgensen S, Nygaard R, Posnett J. Meeting the challenges of wound care in Danish home care. J Wound Care. 2013;22(10):540-542, 544-545. doi:10.12968/jowc.2013.22.10.540
  5. Lindholm C, Searle R. Wound management for the 21st century: combining effectiveness and efficiency. Int Wound J. 2016;13(Suppl 2):5-15. doi:10.1111/iwj.12623
  6. Santamaria N. Woundswest: identifying the prevalence of wounds within western Australia's public health system. Eur Wound Manag Assoc. 2009;9(3):13-18.
  7. Gökalp Özkorkmaz E, Özay Y. Yara iyileşmesi ve yara iyileşmesinde kullanılan bazı bitkiler. Turk Bil Derl Derg. 2009;2(2):63-67.
  8. Dorai AA. Wound care with traditional, complementary and alternative medicine. Indian J Plast Surg. 2012;45(02):418-424. doi:10.4103/0970-0358.101331
  9. Durusoy Ç, Gözel Ulusal B. Dermatolojide bitkisel tedavi-fitoterapi. Turk J Dermatol. 2007;1:47-50.
  10. Yücel A, Kan Y, Yesilada E, Akın O. Effect of St. John's wort (Hypericum perforatum) oily extract for the care and treatment of pressure sores; a case report. J Ethnopharmacol. 2017;196:236-241. doi:10.1016/j.jep.2016.12.030
  11. Klemow KM, Bartlow A, Crawford J, et al. Medical Attributes of St. John’s Wort (Hypericum perforatum) In: Benzie IFF, Wachtel-Galor S, eds. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd ed. CRC Press/Taylor & Francis; 2011. Chap 11. Accessed Jan 16, 2024. https://www.ncbi.nlm.nih.gov/books/NBK92750/
  12. Sarı AO, Bilgin O, Bilgiç A, Tort N, Güvensen A, Şenol SG. Ege ve Güney Marmara bölgelerinde halk ilacı olarak kullanılan bitkiler. J Aegean Agric Res Inst. 2010;20(2):1-21.
  13. Jarahi M, Vafaei AA. Effect of topical phenytoin cream on linear incisional wound healing in albino rats. DARU J Pharmaceutical Sci. 2004;12(4):156-158.
  14. Meguellati H, Ouafi S, Saad S, Djemouai N. Evaluation of acute, subacute oral toxicity and wound healing activity of mother plant and callus of Teucrium polium L. subsp. geyrii Maire from Algeria. South Afr J Bot. 2019;127:25-34. doi:10.1016/j.sajb.2019.08.023
  15. Guo Sa, DiPietro LA. Factors affecting wound healing. J Dent Res. 2010;89(3):219-229. doi:10.1177/0022034509359125
  16. Ghosh PK, Gaba A. Phyto-extracts in wound healing. J Pharm Pharmaceut Sci. 2013;16(5):760-820. doi:10.18433/J3831V
  17. Tatke P, Nehete M, Gabhe S. Antioxidant, antimicrobial and wound healing activity of Salvadora persica twig extracts. J Complement Med Alternat Healthc. 2018;7(4):1-6.
  18. Nayak SB, Isik K, Marshall JR. Wound-healing potential of oil of Hypercium perforatum in excision wounds of male sprague dawley rats. Adv Wound Care (New Rochelle). 2017;6(12):401-406. doi:10.1089/wound.2017.0746
  19. Uzunhisarcıklı E, Yerer MB. Role of Hypericum perforatum oil and pomegranate seed oil in wound healing: an in vitro study. Z Naturforsch C J Biosci. 2022;77(5-6):189-195. doi:10.1515/znc-2020-0301
  20. Yadollah-Damavandi S, Chavoshi-Nejad M, Jangholi E, et al. Topical Hypericum perforatum improves tissue regeneration in full-thickness excisional wounds in diabetic rat model. Evid Based Complement Alternat Med. 2015;2015:245328. doi:10.1155/2015/245328
  21. Green KA, Almholt K, Ploug M, et al. Profibrinolytic effects of metalloproteinases during skin wound healing in the absence of plasminogen. J Invest Dermatol. 2008;128(8):2092-2101.
  22. Ciğer S. Yara iyileşmesi ve büyüme faktörleri. In: Erdem C, Çelebi C, eds. Tüm Yönleriyle Yara İyileşmesi Kitabı (Online). Türk Dermatopatoloji Derneği Yayınları; 2017. Accessed Jan 22, 2024 https://www.dermaneturk.com/yara_online/buyume_faktor.doc
  23. De Francesco F, De Francesco M, Riccio M. Hyaluronic acid/Collagenase ointment in the treatment of chronic hard-to-heal wounds: an observational and retrospective study. J Clin Med. 2022;11(3):537. doi:10.3390/jcm11030537
  24. Taçyıldız İH, Mızraklı S, Aban N, Akkuş M, Kavak V. Yara iyileşmesi üzerine kollagenazın etkisi. Turk J Trauma Emerg Surg. 1998;4(1):7-11.
  25. Nayak SB, Rodrigues V, Maharaj S, Bhogadi VS. Wound healing activity of the fruit skin of Punica granatum. J Med Food. 2013;16(9):857-861. doi:10.1089/jmf.2012.0229
  26. Ersoy E, Özkan EE. Yeni çalışmalar ışığında Hypericum türlerinin farmakolojik aktiviteleri. Sağlık Bil İleri Araşt Derg. 2019;2(2):71-79. doi:10.26650/JARHS2019-616370
  27. Eğri Ö, Erdemir N. Production of Hypericum perforatum oil-loaded membranes for wound dressing material and in vitro tests. Artif Cells, Nanomed Biotechnol. 2019;47(1):1404-1415. doi:10.1080/21691401.2019.1596933
  28. Öztürk N, Korkmaz S, Öztürk Y. Wound-healing activity of St. John's Wort (Hypericum perforatum L.) on chicken embryonic fibroblasts. J Ethnopharmacol. 2007;111(1):33-39. doi:10.1016/j.jep.2006.10.029
  29. Lavagna SM, Secci D, Chimenti P, Bonsignore L, Ottaviani A, Bizzarri B. Efficacy of Hypericum and Calendula oils in the epithelial reconstruction of surgical wounds in childbirth with caesarean section. Farmaco. 2001;56(5-7):451-453. doi:10.1016/s0014-827x(01)01060-6
  30. Darcan S. Investigation of the Effects of Hypericum perforatum Ointment on the Streptozotocin Induced Diabetic Rat Skin Wounds. Master’s thesis. Dumlupınar University; 2013. (in Turkish).
  31. Süntar IP, Akkol EK, Yılmazer D, et al. Investigations on the in vivo wound healing potential of Hypericum perforatum L. J Ethnopharmacol. 2010;127(2):468-477. doi:10.1016/j.jep.2009.10.011
  32. Öz C. The Epithelialisation Effect of Hypericum perforatum L. Extract on an Experimental Burn Model Formed on Rats. Master’s thesis. Süleyman Demirel University; 2011. (in Turkish).
  33. Pekşen M, Atilla K, Soylu S, et al. Comparison of the healing effects of silver sulfadiazine cream 1% and the essential oil of Hypericum perforatum on scald burn wound in a rat model. Basic Clin Sci. 2014;3(1):1-8. doi:10.12808/bcs.v3i1.5000078017
  34. Saddiqe Z, Naeem I, Maimoona A. A review of the antibacterial activity of Hypericum perforatum L. J Ethnopharmacol. 2010;131(3):511-521. doi:10.1016/j.jep.2010.07.034
  35. Kıyan S, Uyanıkgil Y, Altuncı YA, Çavuşoğlu T, Çetin Uyanıkgil EÖ, Karabey F. Investigation of acute effects of Hypericum perforatum (St. John's Wort-Kantaron) treatment in experimental thermal burns and comparison with silver sulfadiazine treatment. Ulus Travma Acil Cerrahi Derg. 2015;21(5):323-36. doi:10.5505/tjtes.2015
  36. Gunpinar S, Kilic OA, Duran I, Tosun M, Firat T, Soyler G. Evaluation of the effect of topical Hypericum perforatum oil on excisional palatal wound healing in rabbits. J Invest Surg. 2020;33(1):49-58. doi:10.1080/08941939.2018.1474980
  37. Altan A, Aras MH, Damlar İ, Gökçe H, Özcan O, Alpaslan C. The effect of Hypericum perforatum on wound healing of oral mucosa in diabetic rats. Eur Oral Res. 2018;52(3):143-149. doi:10.26650/eor.2018.505