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Journals / Türk Kadın Sağlığı ve Neonatoloji Dergisi / 2020 / Cilt: 2 - Sayı: 3

The place of immunological factors in recurrent pregnancy loss and implantation failures

Tekrarlayan gebelik kaybı ve implantasyon başarısızlıklarında immünolojik faktörlerin yeri

Eser ÇOLAK
Hulusi ZEYNELOGLU
Pages
105–111
Publication Date
2020-09-30
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We conclude that, although the relationship between immunology and infertility is clear, there is still a long way to go to reach a thorough understanding.

📌 3 Key Takeaways

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Objective & Hypothesis:Despite recent advances in assisted reproductive methods and treatments in sustaining fetal viability, recurrent implantation failure (RIF) and recurring pregnancy loss (RPL) still pose significant problems in the context of in vitro fertilization (IVF).
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Key Findings & Data:They demonstrated that infertile patients might suffer from dysregulated immune system cell activities, including CD4+ T helper (Th1, Th2, Th17, and Tregs), peripheral natural killer (pNK), uterine natural killer (uNK) cells.
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Conclusion & Impact:We conclude that, although the relationship between immunology and infertility is clear, there is still a long way to go to reach a thorough understanding.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:infertilite · immünoloji · IVF

Abstract

Despite recent advances in assisted reproductive methods and treatments in sustaining fetal viability, recurrent implantation failure (RIF) and recurring pregnancy loss (RPL) still pose significant problems in the context of in vitro fertilization (IVF). Recent studies focused on the role of immunological factors in the etiology of RIF and RPL. They demonstrated that infertile patients might suffer from dysregulated immune system cell activities, including CD4+ T helper (Th1, Th2, Th17, and Tregs), peripheral natural killer (pNK), uterine natural killer (uNK) cells. Researchers have investigated the use and efficacy of immunosuppressant drugs such as glucocorticoids, intravenous immunoglobulin, and TNF-α blockers in achieving successful implantation in infertile women but the efficacy of these treatments remains to be fully established. We conclude that, although the relationship between immunology and infertility is clear, there is still a long way to go to reach a thorough understanding.

Özet

Canlı bir gebeliğin devamı için yardımcı üreme teknikleri ve tedavi yöntemlerinde gelişmeler sağlansa da, in vitro fertilizasyon (IVF) sonrası tekrarlayan implantasyon başarısızlığı (TİB) ve tekrarlayan gebelik kayıpları (TGK) büyük problem oluşturmaktadır. Son yıllarda yapılan çalışmalarda TİB ve TGK nedeni olarak immunolojik faktörlerin üzerinde durulmaktadır ve bu hasta gruplarında immun sistem hücreleri olan; CD4+ T-helper (Th1, Th2, Th17, Treg) ve periferik natural killer (pNK) ve uterin natural killer (uNK) hücrelerinin aktivitelerinde dengesizlikler gösterilmiştir. Bu nedenle, bu hasta gruplarında başarılı bir implantasyon ve gebelik devamı için glukokortikoidler, intravenöz immünoglobulin ve TNF-α blokerleri gibi immünosüpresan ilaçların kullanımı ve etkinliği araştırılmıştır. Ancak ilaçların etkinliği ile ilgili net bir sonuç elde edilmemiştir. Sonuç olarak, immunoloji ile infertilite ilişkisi aşikar olmasına rağmen, bu konuda daha katedilmesi gereken uzun bir yol vardır.

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Cite This Article

ÇOLAK, E., ZEYNELOGLU, H. (2020). The place of immunological factors in recurrent pregnancy loss and implantation failures. Türk Kadın Sağlığı ve Neonatoloji Dergisi, Cilt: 2 - Sayı: 3, 105–111. https://ajindex.com/articles/811689

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References (13)

  1. Stanford JB. What is the true prevalence of infertility? Fertil Steril 2013; 99:1201-1202.
  2. Dahl M, Hviid TVF. Human leucocyte antigen class Ib molecules in pregnancy success and early pregnancy loss. Hum Reprod Update 2012; 18:92-109.
  3. Coughlan C, Ledger W, Wang Q, et al. Recurrent implantation failure: definition and management. Reprod Biomed Online 2014; 28: 14-38.
  4. Ehrlich S, Williams PL, Missmer SA, et al. Urinary bisphenol A concentrations and implantation failure among women undergoing in vitro fertilization. Environ Health Perspect 2012; 120: 978-983. Medawar PB. Some immunological and endocrinological problems raised by the evolution of viviparity in vertebrates. Symp Soc Exp Biol 1953; 7: 320-338.
  5. Lee SK, Kim CJ, Kim DJ, Kang JH. Immune cells in the female reproductive tract. Immune Netw 2015; 15: 16-26. Garcia-Velasco JA. Introduction: Immunology and assisted reproductive technology in the 21st century. Fertil Steril 2017; 107: 1267-1268.
  6. Azargoon A, Mirrasouli Y, Shokrollahi Barough M, Barati M, Kokhaei P. The State of Peripheral Blood Natural Killer Cells and Cytotoxicity in Women with Recurrent Pregnancy Loss and Unexplained Infertility. Int J Fertil Steril 2019; 13:12-17.
  7. Tang AW, Alfirevic Z, Quenby S. Natural killer cells and pregnancy outcomes in women with recurrent miscarriage and infertility: a systematic review. Hum Reprod 2011; 26:1971-1980. Moffett-King A. Natural killer cells and pregnancy. Nat Rev Immunol 2002; 2:656-663.
  8. Moffett A, Shreeve N. First do no harm: uterine natural killer (NK) cells in assisted reproduction. Hum Reprod 2015; 30:1519-1525.
  9. Souza SS, Ferriani RA, Santos CMP, Voltarelli JC. Immunological evaluation of patients with recurrent abortion. J Reprod Immunol 2002; 56:111-121.
  10. Björkström NK, Ljunggren HG, Michaëlsson J. Emerging insights into natural killer cells in human peripheral tissues. Nat Rev Immunol 2016; 16:310-320.
  11. Kalkunte SS, Mselle TF, Norris WE, Wira CR, Sentman CL, Sharma S. Vascular endothelial growth factor C facilitates immune tolerance and endovascular activity of human uterine NK cells at the maternal-fetal interface. J Immunol 2009; 182:4085-4092. Faas MM, de Vos P. Uterine NK cells and macrophages in pregnancy. Placenta 2017; 56: 44-52.
  12. King K, Smith S, Chapman M, Sacks G. Detailed analysis of peripheral blood natural killer (NK) cells in women with recurrent miscarriage. Hum Reprod 2010; 25:52-58.
  13. Hosseini S, Zarnani AH, Asgarian-Omran H, et al. Comparative analysis of NK cell subsets in menst