Results: The mean ALT, TSH and uric acid values were statistically significantly higher in Group OW compared to Group NW (for all, p
📌 3 Key Takeaways
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Objective & Hypothesis:Background: In this study we aimed to evaluate biochemical, lipid and glycemic parameters and to compare serum neprilysin levels between overweight (OW) and normal weight (NW) young women who are more prone to gain weight.
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Key Findings & Data:Material and Methods: A total of 28 overweight/obese women aged between 22-34 years and 34 age matched normal-weight women were included in this cross-sectional study on voluntary basis. of the subjects were performed, Participants’ anthropometric measurements, hormone profiles, glycemic parameters and insulin resistance, and serum neprilysin levels were recorded and analyzed.
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Conclusion & Impact:Results: The mean ALT, TSH and uric acid values were statistically significantly higher in Group OW compared to Group NW (for all, p
Background: In this study we aimed to evaluate biochemical, lipid and glycemic parameters and to compare serum neprilysin levels between overweight (OW) and normal weight (NW) young women who are more prone to gain weight. Material and Methods: A total of 28 overweight/obese women aged between 22-34 years and 34 age matched normal-weight women were included in this cross-sectional study on voluntary basis. of the subjects were performed, Participants’ anthropometric measurements, hormone profiles, glycemic parameters and insulin resistance, and serum neprilysin levels were recorded and analyzed. Patients were evaluated in two groups as Group OW and Group NW. Results: The mean ALT, TSH and uric acid values were statistically significantly higher in Group OW compared to Group NW (for all, p
CANDER, S., GÜL, Ö. Ö. (2022). Investigation of serum neprilysin levels in overweight and normal weight young women. Turkish Journal of Internal Medicine, Supplement 1, 55–62. https://ajindex.com/articles/808981
Sand AS, Emaus N, Lian O. Overweight and obesity in young adult women: A matter of health or appearance? The Tromsø study: Fit futures. Int J Qual Stud Health Well-being. 2015 Sep 22;10:29026. doi: 10.3402/qhw.v10.29026. Tan HS, Habib AS. Obesity in women: anaesthetic implications for peri-operative and peripartum management. Anaesthesia. 2021 Apr;76 Suppl 4:108-117. doi: 10.1111/anae.15403. Wondmkun YT. Obesity, insulin resistance, and type 2 diabetes: Associations and therapeutic implications. Diabetes Metab Syndr Obes. 2020 Oct 9;13:3611-6. doi: 10.2147/DMSO. S275898. Wane S, van Uffelen JG, Brown W. Determinants of weight gain in young women: a review of the literature. J Womens Health (Larchmt). 2010 Jul;19(7):1327-40. doi: 10.1089/jwh.2009.1738. Turner AJ. Neprilysin. In: Barret AJ, Rawlings ND, Woessner JF, eds. Handbook of Proteolytic Enzymes. Amsterdam: Elsevier; 2004;419-26.
Standeven KF, Hess K, Carter AM, Rice GI, Cordell PA, Balmforth AJ, Lu B, Scott DJ, Turner AJ, Hooper NM, Grant PJ. Neprilysin, obesity and the metabolic syndrome. Int J Obes (Lond). 2011 Aug;35(8):1031-40. doi: 10.1038/ijo.2010.227. Moro C. Targeting cardiac natriuretic peptides in the therapy of diabetes and obesity. Expert Opin Ther Targets. 2016 Dec;20(12):1445-52. doi: 10.1080/14728222.2016.1254198. Schling P, Schäfer T. Human adipose tissue cells keep tight control on the angiotensin II levels in their vicinity. J Biol Chem. 2002 Dec 13;277(50):48066-75. doi: 10.1074/jbc.M204058200. Arbin V, Claperon N, Fournié-Zaluski MC, Roques BP, Peyroux J. Effects of dual angiotensin-converting enzyme and neutral endopeptidase 24-11 chronic inhibition by mixanpril on insulin sensitivity in lean and obese Zucker rats. J Cardiovasc Pharmacol. 2003 Feb;41(2):254-64. doi: 10.1097/00005344- 200302000-00015.
Wang CH, Leung N, Lapointe N, Szeto L, Uffelman KD, Giacca A, Rouleau JL, Lewis GF. Vasopeptidase inhibitor omapatrilat induces profound insulin sensitization and increases myocardial glucose uptake in Zucker fatty rats: Studies comparing a vasopeptidase inhibitor, angiotensin-converting enzyme inhibitor, and angiotensin II type I receptor blocker. Circulation. 2003 Apr 15;107(14):1923-9. doi: 10.1161/01. CIR.0000062646.09566.CC. Rice GI, Jones AL, Grant PJ, Carter AM, Turner AJ, Hooper NM. Circulating activities of angiotensin-converting enzyme, its homolog, angiotensin-converting enzyme 2, and neprilysin in a family study. Hypertension. 2006 Nov;48(5):914-20. doi: 10.1161/01.HYP.00