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Journals / Journal of Surgery and Medicine / 2021 / Cilt: 5 - Sayı: 3

Astaxanthin and Coenzyme Q10 are not synergistic against oxidative damage in cerulein-induced acute pancreatitis

Serulein ile Oluşturulmuş Akut Pankreatit Modelinde Astaksantin ve Koenzim Q10’nin Etkisi Sinerjistik Değildir

Esra Bihter GÜRLER
Dilek ÖZBEYLİ
Hülya BUZCU
Muhammet Emin ÇAM
Meral YÜKSEL
Pages
307–310
Publication Date
2021-03-01
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: In all AP groups, MDA and MPO increased while GSH decreased (P

📌 3 Key Takeaways

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Objective & Hypothesis:Background/Aim: The anti-inflammatory effects of Astaxanthin (ATX) and Coenzyme Q10 (Ubiquinone) are studied in different inflammation models.
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Key Findings & Data:The study aims to investigate the synergistic effect of astaxanthin and Coenzyme Q10 in a rat model of acute pancreatitis.
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Conclusion & Impact:Results: In all AP groups, MDA and MPO increased while GSH decreased (P
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Astaksantin · Koenzim Q10 · oksidatif hasar

Abstract

Background/Aim: The anti-inflammatory effects of Astaxanthin (ATX) and Coenzyme Q10 (Ubiquinone) are studied in different inflammation models. The study aims to investigate the synergistic effect of astaxanthin and Coenzyme Q10 in a rat model of acute pancreatitis. Methods: Twenty-four female Wistar rats were grouped as control (C), carrier-treated control (AP), astaxanthin-treated (ATX; 40 mg/kg), astaxanthin+coenzyme Q10- treated (ATX+Q10; 40 mg/kg and 1 gr/kg) groups. Cerulein was administered (50 µg/kg) twice, one hour apart. Seven hours after the first cerulein injection, the rats were sacrificed. Pancreatic oxidative damage was evaluated with an increase in the serum activity of lipase and amylase, tissue levels of myeloperoxidase activity (MPO), malondialdehyde (MDA), luminol and lucigenin and decrease of glutathione. Results: In all AP groups, MDA and MPO increased while GSH decreased (P

Özet

Amaç: Astaksantin (ATX) ve Koenzim Q10'un (Ubiquinone) çeşitli antiinflamatuvar etkileri farklı inflamasyon modellerinde incelenmiştir. Bu çalışma, sıçan akut pankreatit modelinde astaksantin ve Koenzim Q10'un sinerjistik etkisini araştırmayı amaçlamaktadır. Gereç ve Yöntem: 24 adet Wistar sıçan; kontrol (C), taşıyıcı kontrol (AP), astaksantin (ATX; 40 mg / kg), astaksantin + koenzim Q10 (ATX + Q10; ATX+Q10; 40 mg/kg and 1 gr/kg) olarak gruplandırıldı. Bir saat ara ile iki kez serulein (50 ug / kg) uygulandı. İlk serulein enjeksiyonundan 7 saat sonra sıçanlar öldürüldü. Pankreatik oksidatif hasar, lipaz ve amilazın serum düzeyinde, miyeloperoksidaz aktivitesi (MPO), malondialdehit (MDA), luminol ve lucigenin doku seviyelerinde artışı ve glutatyonın doku seviyesindeki azalması ile değerlendirildi. Bulgular: Tüm AP gruplarında MDA, MPO artarken GSH azaldı (p <0.001). ATX veya ATX + Q10, artmış MDA ve MPO düzeylerini anlamlı şekilde düşürürken (p <0.001) azalmış GSH düzeyinde artışa neden oldu. (p <0.01) . Her iki tedavi de luminol düzeylerini arttırdı (p <0.001) (p <0.01). Lucigenin Q10 grubunda belirgin olarak azaldı (p <0.01). Sonuç: Antioksidan kombinasyon tedavisi pankreatik dokudaki oksidatif hasarı tek başına astaksantinden daha iyi hafifletmemektedir.

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Cite This Article

GÜRLER, E. B., ÖZBEYLİ, D., BUZCU, H., ÇAM, M. E., YÜKSEL, M. (2021). Astaxanthin and Coenzyme Q10 are not synergistic against oxidative damage in cerulein-induced acute pancreatitis. Journal of Surgery and Medicine, Cilt: 5 - Sayı: 3, 307–310. https://ajindex.com/articles/780040

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