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Journals / Journal of Surgery and Medicine / 2021 / Cilt: 5 - Sayı: 4

Two natural materials found to reduce adhesion formation in a rat uterine horn model

Erkan ELÇİ
Sena SAYAN
Gülhan ELÇİ
İbrahim ARAS
Numan ÇİM
Harun Egemen TOLUNAY
Yıldıray BASBUGAN
Pages
371–375
Publication Date
2021-04-01
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Results: The extent, severity, degree, total adhesion, inflammation, and fibrosis scores of the control group were significantly higher than those of the TRZ and HAF groups (P

📌 3 Key Takeaways

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Objective & Hypothesis:Background/Aim: Post-operative pelvic adhesions cause various problems in patients, pose surgical difficulties to clinicians, and an increase in health costs.
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Key Findings & Data:We compared the effectiveness of two natural materials, Trehalose (TRZ), Human Amnion Fluid (HAF), with oxidized regenerated cellulose (ORC) in terms of adhesion prevention after gynecological operations.
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Conclusion & Impact:Results: The extent, severity, degree, total adhesion, inflammation, and fibrosis scores of the control group were significantly higher than those of the TRZ and HAF groups (P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Adhesions · human amnion fluid · interceed

Abstract

Background/Aim: Post-operative pelvic adhesions cause various problems in patients, pose surgical difficulties to clinicians, and an increase in health costs. We compared the effectiveness of two natural materials, Trehalose (TRZ), Human Amnion Fluid (HAF), with oxidized regenerated cellulose (ORC) in terms of adhesion prevention after gynecological operations. Methods: In this controlled experimental study, twenty-four female Wistar Hannover rats were divided into four groups: Control, TRZ, HAF, and ORC. The control group received medication used for the surgical procedure only. 3% TRZ, cell-free HAF, and 1 cm2 ORC (interceed®) were laid on the tissue on the antimesenteric side of each uterine horn damaged with a 10-Watt bipolar cautery. Adhesions were scored 30 days after the first surgical procedure. Results: The extent, severity, degree, total adhesion, inflammation, and fibrosis scores of the control group were significantly higher than those of the TRZ and HAF groups (P

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Cite This Article

ELÇİ, E., SAYAN, S., ELÇİ, G., ARAS, İ., ÇİM, N., TOLUNAY, H. E., BASBUGAN, Y. (2021). Two natural materials found to reduce adhesion formation in a rat uterine horn model. Journal of Surgery and Medicine, Cilt: 5 - Sayı: 4, 371–375. https://ajindex.com/articles/779989

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