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Journals / Journal of Surgery and Medicine / 2021 / Cilt: 5 - Sayı: 5

The association of TNFα -238 G/A gene polymorphism with alopecia areata

Nazlı DİZEN NAMDAR
Raziye AKCILAR
Pages
463–466
Publication Date
2021-05-01
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Results: The distribution of TNFα -238 G/A genotypes was significantly different between patients and control subjects (P

📌 3 Key Takeaways

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Objective & Hypothesis:Background/Aim: Alopecia areata (AA), which is characterized by hair loss, is an inflammatory autoimmune disease.
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Key Findings & Data:Tumor necrosis factor-alpha (TNFα) is a potent proinflammatory cytokine that has a highly significant role in inflammatory and immune responses.
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Conclusion & Impact:Results: The distribution of TNFα -238 G/A genotypes was significantly different between patients and control subjects (P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:TNFα · Gene polymorphism · Alopecia areata

Abstract

Background/Aim: Alopecia areata (AA), which is characterized by hair loss, is an inflammatory autoimmune disease. Tumor necrosis factor-alpha (TNFα) is a potent proinflammatory cytokine that has a highly significant role in inflammatory and immune responses. The aim of this study is to evaluate whether there is a relationship between TNFα -238 G/A gene polymorphism and AA in the Turkish population. Methods: In this case-control study, the frequency of TNFα-238 G/A gene polymorphism and its relationship with some clinical parameters of AA patients were investigated. Seventy-eight AA patients and 78 healthy individuals were included in our study. TNFα -238 G/A polymorphism was evaluated by the PCR-RFLP method. Results: The distribution of TNFα -238 G/A genotypes was significantly different between patients and control subjects (P

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Cite This Article

NAMDAR, N. D., AKCILAR, R. (2021). The association of TNFα -238 G/A gene polymorphism with alopecia areata. Journal of Surgery and Medicine, Cilt: 5 - Sayı: 5, 463–466. https://ajindex.com/articles/779939

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