While GCT and STP provide a simple and inexpensive field test, serum GGT measurement is not a beneficial test to determine colostrum intake in newborn foals.
📌 3 Key Takeaways
🎯
Objective & Hypothesis:The purpose of the present study was to detect the passive transfer status in healthy neonatal foals by comparing serum immunoglobulin G (sIgG) concentration, serum total protein (STP), glutaraldehyde coagulation test (GCT) duration and gamma glutamyl transferase (GGT) activity .
📊
Key Findings & Data:Fifteen neonatal foals (0-15 days old)’ blood samples were collected before suckling (day 0), 12th hour (hr), 24th hr (1st day), 7th and 15th days.
💡
Conclusion & Impact:While GCT and STP provide a simple and inexpensive field test, serum GGT measurement is not a beneficial test to determine colostrum intake in newborn foals.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Foals · Newborn · Failure of Passive Transfer
Abstract
The purpose of the present study was to detect the passive transfer status in healthy neonatal foals by comparing serum immunoglobulin G (sIgG) concentration, serum total protein (STP), glutaraldehyde coagulation test (GCT) duration and gamma glutamyl transferase (GGT) activity . Fifteen neonatal foals (0-15 days old)’ blood samples were collected before suckling (day 0), 12th hour (hr), 24th hr (1st day), 7th and 15th days. Serum IgG and STP levels significantly increased after the 12th hr. Conversely, serum GCT duration significantly decreased (p< 0.05) in neonatal foals after the 12th hr. The result of the present study was shown that measurements of sIgG, STP concentration and GCT duration are useful parameters to detect Failure of Passive Transfer (FPT) in neonatal foals. While GCT and STP provide a simple and inexpensive field test, serum GGT measurement is not a beneficial test to determine colostrum intake in newborn foals.
KASAP, S., KENNERMAN, E., DULGER, H. (2019). Comparison of Serum IgG Concentration, Total Protein, Glutaraldehyde Coagulation Test and Gamma Glutamyl Transferase in Neonatal Foals. Journal of Research in Veterinary Medicine, Cilt: 38 - Sayı: 1, 35–38. https://ajindex.com/articles/778587
Clabough DL, Conboy HS, Roberts MC. Comparison of four screening techniques for the diagnosis of equine neonatal hypogammaglobulinemia. J Am Vet Med Assoc. 1989
194(12): 1717-1720. 2. Hines MT. Immunodeficiencies of foals. In. Robinson NE, ed. Current Therapy in Equine Medicine. 4th ed. Philederphia, W.B. Saunders Company
McCue PM. Evaluation of a turbidimetric immunoassay for measurement of plasma IgG concentration in foals. Am J Vet Res. 2007
68(9):1005-1009. 4. Cohen ND. Causes of and farm management factors associated with disease and death in foals. J Am Vet Med Assoc. 1994
204(10):1644-1651. 5. Hurcombe SD, Toribio RE, Slovis N, et al. Blood arginine vasopressin, adrenocorticotropin hormone, and cortisol concentrations at admission in septic and critically ill foals and their association with survival. J Vet Intern Med. 2008
22(3):639-647. 6. Davis R, Giguère S. Evaluation of five commercially available assays and measurement of serum total protein concentration via refractometry for the diagnosis of failure of passive transfer of immunity in foals. J Am Vet Med Assoc. 2005
227(10):1640-1645. 7. Beetson SA, Hilbert BJ, Mills JN. The use of the glutaraldehyde coagulation test for detection of hypogammaglobulinaemia in neonatal foals. Aust Vet J. 1985
62(8):279-281. 8. LeBlanc MM, Hurtgen JP, Lyle S. A modified zinc sulfate turbidity test for the detection of immune status in newly born foals. J Equine Vet Sci. 1990
36–39. 9. Pusterla N, Pusterla JB, Spier SJ, et al. Evaluation of the SNAP foal IgG test for the semiquantitative measurement of immunoglobulin G in foals. Vet Rec. 2002
151(9): 258-260. 10. Metzger N, Hinchcliff KW, Hardy J, et al. Usefulness of a commercial equine IgG test and serum protein concentration as indicators of failure of transfer of passive immunity in hospitalized foals. J Vet Intern Med. 2006
20(2): 382-387. 11. Korosue K, Murase H, Sato F, et al. Correlation of serum IgG concentration in foals and refractometry index of the dam’s pre- and post-parturient colostrums: an assessment for failure of passive transfer in foals. J Vet Med Sci. 2012
74(11): 1387-1395. 12. Baird AN, Pugh DG, Rupp GP, et al. Detection of immunoglobulin G in the neonate. J Equine Vet Sci. 1987
Knottenbelt DC, Holdstock N, Madigan J. Equine neonatology medicine and surgery. London, Saunders
Tyler-McGowan CM, Hodgson JL, Hodgson DR. Failure of passive transfer in foals: incidence and outcome on four studs