Journals / Journal of Medicine and Palliative Care / 2020 / Cilt: 1 - Sayı: 3

Effect of Teucrium polium L. plant on HepG2 cell line grown in Turkey

Türkiye’de yetişen Teucrium polium L. bitkisinin HepG2 hücre hattı üzerindeki etkisi

Pages
49–52
Publication Date
2020-09-21
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: According to the results, Teucrium polium L. plant has shown high level of toxicity on the HepG2 cell line.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Introduction: Some plants have been used for medicinal purpose for centuries.
📊
Key Findings & Data:Plant on HepG2 Cell Line Plant Grown in Turkey.
💡
Conclusion & Impact:Results: According to the results, Teucrium polium L. plant has shown high level of toxicity on the HepG2 cell line.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:HepG2 · Teucrium polium L. · toksisite

Abstract

Introduction: Some plants have been used for medicinal purpose for centuries. One of the most popular plant is Teucrium polium L. that is used by Persian and Southeastern Anatolia Region of Turkey for many pathological situations such as gastrointestinal disturbance, inflammation and diabetes. There are no study showing the level of toxicity of the Teucrium polium L. in the literature. The aim of this study is to investigate the effect of Teucrium polium L. Plant on HepG2 Cell Line Plant Grown in Turkey. Material and Method: To measure of the toxicity levels Teucrium polium L. plant, cell culture method was used. Results: According to the results, Teucrium polium L. plant has shown high level of toxicity on the HepG2 cell line. Conclusion: According to our findings, unconsciously consumed products, even if they are natural, could be destroying in human body, or causing deaths and DNA breaking. Teucrium polium L. plant is not suitable for human use.

Özet

Giriş: Bazı bitkiler yüzyıllardır tıbbi amaç için kullanılmaktadır. Gastrointestinal bozukluklar, inflamasyon ve diyabet gibi bazı patolojik durumlar için İranlılar ve Türkiye’nin Güneydoğu Anadolu Bölgesi tarafından kullanılan en popüler bitkilerden biri Teucrium polium L. ‘dir. Literatürde Teucrium polium L. bitkisinin toksisite seviyesini gösteren herhangi bir çalışma bulunmamaktadır. Bu çalışmada amaç; Türkiye’de yetişen Teucrium polium L. bitkisinin HepG2 hücre hattı üzerindeki etkisini araştırmaktır. Gereç ve Yöntem: Çalışmamızda; Teucrium polium L. bitkisinin toksisite seviyesini ölçmek için hücre kültürü metodu kullanılmıştır. Bulgular: Araştırmamızdan elde ettiğimiz sonuçlara göre; Teucrium polium L. bitkisi HepG2 hücre hattı üzerinde yüksek oranda toksisite göstermiştir.Sonuç: Çalışmamızdan elde ettiğimiz bilgilere göre; insanların bilinçsizce tükettiği ürünler doğal da olsa, insan vücudunda tahribatlara, hücre ölümlerine, DNA kırıklarına neden olabilir. Teucrium polium L. bitkisi insanlar tarafından kullanıma uygun değildir.

🔖

Cite This Article

SANCAK, N., KIRKIK, D., ALRAGABİ, J. (2020). Effect of Teucrium polium L. plant on HepG2 cell line grown in Turkey. Journal of Medicine and Palliative Care, Cilt: 1 - Sayı: 3, 49–52. https://ajindex.com/articles/777666

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. El Oualidi J, Verneau O, Puech S, Dubuisson JY. Utility of rDNA ITS sequences in the systematics of Teucrium section polium (lamiaceae). Plant Syst Evol 1999; 215: 49–70.
  2. Feinbrun-Dothan N. Flora Palaestina, Part three. Israel Acad Sci Hum 1970; 3: 101–6.
  3. Tapeh NG, Bernousi I, Moghadam AF, Mandoulakani BA. Genetic diversity and structure of Iranian Teucrium (Teucrium polium L.) populations assessed by ISSR markers. J. Agr Sci Tech 2018; 20: 333-45.
  4. Piozzi F, Bruno M, Rosselli S, Maggio A. Advances on the chemistry of furano-diterpenoids from Teucrium genus. Heterocycles 2005; 65: 1221–34.
  5. Abdollahi M, Karimpour H, Monsef-Esfehani HR. Antinociceptive effects of Teucrium polium L. total extract and essential oil in mouse writhing test. Pharm Re 2003; 48: 31–5.
  6. Esmaeili MA, Yazdanparast R. Hypoglycaemic effect of Teucrium polium: studies with rat pancreatic islets. J Ethnopharmacol 2004; 95: 27–30.
  7. Tariq M, Ageel AM, al-Yahya MA, Mossa JS, al-Said MS. Anti-inflammatory activity of Teucrium polium. Int J Tissue React 1989; 11: 185–8.
  8. Autore G, Capasso F, De Fusco R, et al. Antipyretic and antibacterial actions of Teucrium polium. Pharmacol Res Commun 1984; 16: 21–9.
  9. Gharaibeh MN, Elayan HH, Salhab AS. Anorexic effect of Teucrium polium in rats. Int J Crude Drug Res. 1989; 27: 201–7
  10. Suleiman MS, Abdul-Ghani AS, Al-Khalil S, Amin R. Effect of Teucrium polium boiled leaf extract on intestinal motility and blood pressure. J Ethnopharmacol 1988; 22: 111–6.
  11. Khader M, Bresgen N, Eckl PM. Antimutagenic effects of ethanolic extracts from selected Palestinian medicinal plants. J Ethnopharmacol 2010; 127: 319–24.
  12. Khader M, Eckl PM, Bresgen N. Effects of aqueous extracts of medicinal plants on MNNG-treated rat hepatocytes in primary cultures. J Ethnopharmacol 2007; 112: 199–202.
  13. Nematollahi-Mahani SN, Rezazadeh-Kermani M, Mehrabani M, Nakhaee N. Cytotoxic effects of Teucrium polium on some established cell lines. Pharm Biol 2007; 45: 295–8
  14. Bukhari NA, Al-Otaibi RA, Ibhrahim MM. Biodiversity characteristics of Teucrium polium species in Saudi Arabia. Saudi J Biol Sci 2015; 22: 2: 181-5.
  15. Ansari M, Sharififar F, Arabzadeh AM, et al. In vitro evaluation of anti-herpes simplex-1 activity of three standardized medicinal plants from Lamiaceae. Anc Sci Life 2014; 34:1- 33-8.
  16. Purnavab S, Ketabchi S, Rowshan V. Chemical composition and antibacterial activity of methanolic extract and essential oil of Iranian Teucrium polium against some of phytobacteria. Nat Prod Res, 2015; 29:14: