This literature article reviewed studies using stem cell-derived EVs in numerous clinical and preclinical studies.
📌 3 Key Takeaways
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Objective & Hypothesis:Extracellular vesicles (EVs) are vesicles secreted by cells into the extracellular space, first discovered in 1967 as platelet dust.
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Key Findings & Data:In recent years, the idea that EVs can treat various diseases has emerged in studies to understand these vesicles' origin and biological functions.
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Conclusion & Impact:This literature article reviewed studies using stem cell-derived EVs in numerous clinical and preclinical studies.
Extracellular vesicles (EVs) are vesicles secreted by cells into the extracellular space, first discovered in 1967 as platelet dust. In recent years, the idea that EVs can treat various diseases has emerged in studies to understand these vesicles' origin and biological functions. According to their size, biogenesis, content, release pathways and function, EVs have three main subtypes: microvesicle (MV), exosome (EX) and apoptotic body. EVs are found in all body fluids, including urine, plasma, and physiological fluids such as bronchial lavage. In addition, it is secreted by many cell types such as dendritic cells, B cells, T-cells, mast cells, tumour cells, and sperm. This literature article reviewed studies using stem cell-derived EVs in numerous clinical and preclinical studies.
ÖNER, Ö., KARA, S. G., KARAKAYA, İ., SARIBOYACI, A. E., UYSAL, O., GÜNEŞ, S., AVCİ, H. (2021). The Smallest Workers in Regenerative Medicine: Stem Cell-Derived Exosomes. Journal of Medical Innovation and Technology, Cilt: 3 - Sayı: 2, 58–67. https://ajindex.com/articles/777589
Liu W, Ma Z, Li J, Kang X. Mesenchymal stem cell-derived exosomes: therapeutic opportunities and challenges for spinal cord injury. Stem Cell Research & Therapy. 2021 Dec 3;12(1). Biancone L, Bruno S, Deregibus MC, Tetta C, Camussi G. Therapeutic potential of mesenchymal stem cell-derived microvesicles. Nephrology Dialysis Transplantation. 2012 Aug 1;27(8). Lai RC, Yeo RWY, Tan KH, Lim SK. Exosomes for drug delivery — a novel application for the mesenchymal stem cell. Biotechnology Advances. 2013 Sep;31(5). Gutierrez‐Millan C, Calvo Díaz C, Lanao JM, Colino CI. Advances in Exosomes‐Based Drug Delivery Systems. Macromolecular Bioscience. 2021 Jan 22;21(1). Semedo P, Burgos-Silva M, Donizetti-Oliveira C, Saraiva Camar NO. How do Mesenchymal Stem Cells Repair? In: Stem Cells in Clinic and Research. InTech; 2011.
Güneş S, Uysal O, Sevimli T, Sevimli M, Tokhi A, Sarıboyacı A. Kök Hücreler. In: Avci H, editor. Polimerler: Özellikleri ve Uygulamaları. 1st ed. ESOGU; 2021. p. 325–49.
Song Y, Kim Y, Ha S, Sheller‐Miller S, Yoo J, Choi C, et al. The emerging role of exosomes as novel therapeutics: Biology, technologies, clinical applications, and the next. American Journal of Reproductive Immunology. 2021 Feb 12;85(2). E Z, G. M, Momen-Heravi F, Hu J, Zhang X, Wu Y, et al. Therapeutic uses of exosomes. Exosomes and Microvesicles. 2013
Watanabe Y, Tsuchiya A, Terai S. The development of mesenchymal stem cell therapy in the present, and the perspective of cell-free therapy in the future. Clinical and Molecular Hepatology. 2021 Oct;27(1) Khan M, Nickoloff E, Abramova T, Johnson J, Verma SK, Krishnamurthy P, et al. Embryonic Stem Cell–Derived Exosomes Promote Endogenous Repair Mechanisms and Enhance Cardiac Function Following Myocardial Infarction. Circulation Research. 2015 Oct;117(1). Ranghino A, Bruno S, Bussolati B, Moggio A, Dimuccio V, Tapparo M, et al. The effects of glomerular and tubular renal progenitors and derived extracellular vesicles on recovery from acute kidney injury. Stem Cell Research & Therapy. 2017 Oct;8(1). McBride JD, Rodriguez-Menocal L, Guzman W, Candanedo A, Garcia-Contreras M, Badiavas E v. Bone Marrow Mesenchymal Stem Cell-Derived CD63 + Exosomes Transport Wnt3a Exteriorly and Enhance Dermal Fibroblast Proliferation, Migration, and Angiogenesis In Vitro. Stem Cells and Development. 2017 Oct;26(19). Zhang S, Chuah SJ, Lai RC, Hui JHP, Lim SK, Toh WS. MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and m