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Journals / International Archives of Medical Research / 2019 / Cilt: 11 - Sayı: 2

Is there an association between immunohistochemical parameters of breast cancer and metabolic parameters obtained with 18F-fluorodeoxyglucose PET / CT?

Sadiye ALTUN TUZCU
Ayten GEZİCİ
Bekir TAŞDEMİR
İhsan KAPLAN
Hüseyin BÜYÜKBAYRAM
Feray ALTUN ÇETİN
Pages
51–61
Publication Date
2019-12-30
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Conclusions: 1-SUV max, SUVmean and Ki-67 of Oestrogen receptor negative group were statistically higher than Oestrogen receptor positive group. 2-SUVmean and Ki-67 of progesterone receptor negative group were statistically higher than progesteron receptor positive group. 3- HER2 positive and/or triple negative breast cancers were not associated with 18F-FDG PET/CT metabolic parameters

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: The aim of our study to investigate relationship between 18F -fluorodeoxyglucose PET/CT (18F-FDG PET/CT) metabolic parameters and immunohistochemical factors in breast carcinomas.
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Key Findings & Data:Material and method: Patients with breast carcinomas who underwent 18F-FDG PET/CT imaging at our department between May 2018 and November 2019 were included in this study.
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Conclusion & Impact:Conclusions: 1-SUV max, SUVmean and Ki-67 of Oestrogen receptor negative group were statistically higher than Oestrogen receptor positive group. 2-SUVmean and Ki-67 of progesterone receptor negative group were statistically higher than progesteron receptor positive group. 3- HER2 positive and/or triple negative breast cancers were not associated with 18F-FDG PET/CT metabolic parameters
🔬Design:Review & Systematic Survey
📍Scope:2018 Verileri
⚙️Variables:breast cancer · Oestrogen receptor · 18F-FDG PET/CT

Abstract

Introduction: The aim of our study to investigate relationship between 18F -fluorodeoxyglucose PET/CT (18F-FDG PET/CT) metabolic parameters and immunohistochemical factors in breast carcinomas. Material and method: Patients with breast carcinomas who underwent 18F-FDG PET/CT imaging at our department between May 2018 and November 2019 were included in this study. A total of 146 female patients were included (aged 49.1 ± 13.4years; range, 26-87 years). PET scanning was performed in 3D mode from the skull ceiling to the middle of the thigh. Metabolic parameters such as TLG (Total lesion glycolysis), MTV (Metabolic tumor volume) , SUVmean and SUVmax values were calculated. We obtained the histopathological findings, including the size of invasive cancer, histological type, histological grade, ER and PR status, epidermal growth factor receptor (HER2) and Ki-67 of the primary tumor by reviewing the pathology reports. Result: SUV max and SUVmean of Oestrogen receptor negative group were statistically higher than Oestrogen receptor positive group (p=0.009). SUVmean of progesterone receptor negative group were statistically higher than progesterone receptor positive group (p=0.05). Ki-67 of the Oestrogen receptor negative group and progesterone receptor negative group were statistically higher than Oestrogen receptor and progesterone receptor positive group (p=0.001, 0,001 respectively). Both SUVmax and SUVmean of Ki-67 positive group were statistically higher than Ki-67negative group (p=0.0001). Conclusions: 1-SUV max, SUVmean and Ki-67 of Oestrogen receptor negative group were statistically higher than Oestrogen receptor positive group. 2-SUVmean and Ki-67 of progesterone receptor negative group were statistically higher than progesteron receptor positive group. 3- HER2 positive and/or triple negative breast cancers were not associated with 18F-FDG PET/CT metabolic parameters

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Cite This Article

TUZCU, S. A., GEZİCİ, A., TAŞDEMİR, B., KAPLAN, İ., BÜYÜKBAYRAM, H., ÇETİN, F. A. (2019). Is there an association between immunohistochemical parameters of breast cancer and metabolic parameters obtained with 18F-fluorodeoxyglucose PET / CT?. International Archives of Medical Research, Cilt: 11 - Sayı: 2, 51–61. https://ajindex.com/articles/764779

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