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Journals / Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi / 2009 / Sayı: 2

Toxicological Evaluation of Slimming Prepations with Several Ingredients

Zayıflama Amacıyla Kullanılan Çok Etken Maddeli Bazı Preparatların Toksikolojik Açıdan Değerlendirilmesi: Fen-Phen ve Usnik Asit

Belma GİRAY
Pınar ERKEKOĞLU
Gönül ŞAHİN
Pages
131–148
Publication Date
2009-06-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This review will focus on Fen-Phen and usnic acid preparations and the possible toxicological outcomes in the usage of these two kinds of preparations.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:To aid the fighting against weight gain, many drugs or herbal preparations have been used since 1940s.
📊
Key Findings & Data:Fen-Phen preparations contained fenfluramine and phentermine while usnic acid preparations had sodium usniate, phenylpropanolamine, yohimbine, caffeine and 3,5-diiodithyroinine as ingredients.
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Conclusion & Impact:This review will focus on Fen-Phen and usnic acid preparations and the possible toxicological outcomes in the usage of these two kinds of preparations.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Obezite · Zayıflama preparatları · Fen-Pen

Abstract

To aid the fighting against weight gain, many drugs or herbal preparations have been used since 1940s. Some of them are withdrawn from the market because of the serious side effects. Fen-Phen preparations contained fenfluramine and phentermine while usnic acid preparations had sodium usniate, phenylpropanolamine, yohimbine, caffeine and 3,5-diiodithyroinine as ingredients. Fen-Phen usage caused cardiac valvulopathy while preparations with usnic acid caused serious liver toxicity. Furthermore, there were several reports of deaths in patients taking these two kinds of preparations. Although fenfluramine is no longer available, physicians can still prescribe phentermine and preparations of usnic acid are still available on internet sales. This review will focus on Fen-Phen and usnic acid preparations and the possible toxicological outcomes in the usage of these two kinds of preparations.

Özet

Kilo alımına karşı mücadelede 1940’lardan beri birçok ilaç ve bitkisel preparat kullanılmıştır. Bazıları ciddi yan etkilerinden dolayı kullanımdan kalkmıştır. Fen-Phen preparatları fenfluramin ve fentermin, usnik asit preparatları ise sodyum usniyat, fenilpropanolamin, yohimbin, kafein ve 3,5-diiyodotironin içermektedir. Fen-Phen preparatlarının kullanımı kardiyak valvulopatiye, usnik asit preparatlarının kullanımı ise ciddi karaciğer toksisitesine neden olmuştur. Ayrıca her iki tip ürünün kullanımıyla da ölümler görülmüştür. Her ne kadar fenfluramin artık kullanımından kalkmış olsa da, doktorlar halen fentermin ürünlerini reçetelendirmekte ve usnik asit preparatları ise internetten satın alınabilmektedir. Bu derlemede Fen-Phen ve usnik asit preparatlarının kullanımıyla ortaya çıkabilecek toksikolojik sonuçlar üzerinde durulacaktır.

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Cite This Article

GİRAY, B., ERKEKOĞLU, P., ŞAHİN, G. (2009). Toxicological Evaluation of Slimming Prepations with Several Ingredients. Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi, Sayı: 2, 131–148. https://ajindex.com/articles/762415

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References (15)

  1. mokdad, A.H., Serdula, m.K., Dietz, W.H., Bowman, B.A., marks j.S., Koplan j.P.: The spread of the obesity epidemic in the united States, 1991-1998. jAmA, 282, 1519 (1999)
  2. Perharic, L., Shaw, D., murray, V.: Toxic effects of herbal medicines and food supple- ments, Lancet, 342, 180 (1993)
  3. Dunbabin D.W., Tallis G.A., Popplewell P.Y., Lee R.A.: Lead poisoning from Indian herbal medicine (Ayurveda), med j Aust, 157, 835, (1992) Kew, j., morris C., Aihie, A., Fysh, R, jones, S, Brooks, D. Arsenic and mercury intoxi- cation due to Indian ethnic remedies, Bmj, 306, 506, (1993)
  4. Slifman, N.R., obermeyer, W.R., Aloi, B.K., musser, S.m., Correll, W.A. jr, Cichowicz, S.m., Betz, j.m., Love, L.A.: Contamination of botanical dietary supplements by Digi- talis lanata, N Engl j med, 339, 806, (1998)
  5. Vessey, D., “metabolism of Xenobiotics”, Zakin B, (Ed). Hepatology: A Textbook of Liver Disease, 3rd ed, Philadelphia,: WB Saunders, (1996), sayfa 257. james, R.C., Harbison, R.D., Roberts, S.m.: Phenylpropanolamine potentiation of acetaminophen-induced hepatotoxicity: evidence for a glutathione-dependent mecha- nism, Toxicol Appl Pharmacol, 118, 159, (1993)
  6. Fishman, A,P.: Aminorex to fen/phen: an epidemic foretold, Circulation, 99, 156, (1999)
  7. Bray, G.A., Greenway, F.L.: Current and potential drugs for treatment of obesity, En- docr Rev, 20, 805, (1999)
  8. Coleman, E.: Anorectics on trial: A half century of federal regulation of prescriptions appetite suppressants, Ann. Intern med, 143, 380, (2005)
  9. Stafford, R.S., Radley, D.C.: National trends in antiobesity medication use, Arch Intern med, 163, 1046, (2003) Giri, m.: medical management of obesity, Acta Clin Belg, 61, 286, (2006)
  10. Bray, G.A.: Treatment and secondary prevention of obesity, Nutrition,16, 384, (2000) Dixon, j.B.: Weight loss medications--where do they fit in?, Aust Fam Physician, 35, 576, (2006)
  11. Bray, G.A.: Drug treatment of obesity, Rev Endocr metab Disord, 2, 403, (2001)
  12. Schnee, D.m., Zaiken, K., mcCloskey, W.W: Curr med Res opin, 22, 463, (2006)
  13. Ioannides-Demos, L.L., Proietto, j., Tonkin, A.m., mcNeil, j.j.: Safety of drug thera- pies used for weight loss and treatment of obesity. Drug Saf, 29, 277, (2006)
  14. Greenway FL, Caruso mK.: Safety of obesity drugs. Expert opin Drug Saf, 4, 1083, (2005)
  15. Li, Z., maglione, m., Tu, W., mojica, W., Arterburn, D., Shugarman, L.R., Hilton, L., Suttorp, m., Solomon, V., Shekelle, P.G., morton, S.C.: meta-analysis: pharmacologic treatment of obesity. Ann Intern m