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Journals / Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji / 2015 / Cilt: 4 - Sayı: 1

SYNTHESIS and ANTIMICROBIAL ACTIVITY of SOME NOVEL QUINOXALINE HYDRAZONES

BAZI YENİ KİNOKSALİN HİDRAZONLARIN SENTEZİ ve ANTİMİKROBİYAL AKTİVİTELERİ

Esra BAŞYİĞİT
Ulviye ACAR ÇEVİK
Yusuf ÖZKAY
Hülya KARACA GENÇER
Ümit UÇUCU
Pages
31–39
Publication Date
2016-01-12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Furthermore, antibacterial activity of the 2,4-difluoro substituted compound 4b displayed two fold better activity than chloramphenicol against this bacterial strain.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:A new class of 10 novel quinoxaline hydrazones was synthesized to examine their antimicrobial activity.
📊
Key Findings & Data:The structural of the compounds was confirmed by IR, 1H-NMR, and MS spectral data and elemental analyses.
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Conclusion & Impact:Furthermore, antibacterial activity of the 2,4-difluoro substituted compound 4b displayed two fold better activity than chloramphenicol against this bacterial strain.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Kinoksalin · Hidrazon · Antimikrobiyal aktivite

Abstract

A new class of 10 novel quinoxaline hydrazones was synthesized to examine their antimicrobial activity. The structural of the compounds was confirmed by IR, 1H-NMR, and MS spectral data and elemental analyses. Antimicrobial activity of the compounds was evaluated against 3 fungal and 7 bacterial strains by Micro-broth dilution assay. All of the synthesized compounds indicated showed significant antibacterial activity against Pseudomonas aeruginosa. Furthermore, antibacterial activity of the 2,4-difluoro substituted compound 4b displayed two fold better activity than chloramphenicol against this bacterial strain.

Özet

10 yeni kinoksalin hidrazondan oluşan yeni bir grup aktimikrobiyal aktivitesi incelenmek üzere sentezlenmiştir. Bileşiklerin yapıları IR, 1H-NMR, MS spektral ve elemental analiz ile aydınlatılmıştır. Bileşiklerin antimikrobiyal aktiviteleri Mikro-broth dilüsyon yöntemi ile 3 fungus ve 7 bakteri türüne karşı değerlendirilmiştir. Sentezlenen bütün bileşikler Pseudomonas aeruginosa’ ya karşı önemli antibakteriyal aktivite göstermiştir. Ayrıca, 2,4-difloro yapısı içeren 4b bileşiği Pseudomonas aeruginosa’ ya karşı kloramfenikolden 2 kat daha iyi antibakteriyal aktivite göstermiştir

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Cite This Article

BAŞYİĞİT, E., ÇEVİK, U. A., ÖZKAY, Y., GENÇER, H. K., UÇUCU, Ü. (2016). SYNTHESIS and ANTIMICROBIAL ACTIVITY of SOME NOVEL QUINOXALINE HYDRAZONES. Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji, Cilt: 4 - Sayı: 1, 31–39. https://ajindex.com/articles/755403

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References (10)

  1. Akhand, S.S., Pettit, R.S., Gardner, T.E., Anderson, G.G. (2014). New treatments in development for Pseudomonas aeruginosa Infections in the Lungs of Individuals with Cystic Fibrosis. Orphan Drugs Research and Reviews 4. Backes, G.L., Neumann, D.M., Jursic, B.S. (2014). Synthesis and Antifungal Activity of Substituted Salicylaldehyde Hydrazones, Hydrazides and Sulfohydrazides. Bioorganic & Medicinal Chemistry 22(17), 4629–4636.
  2. Becker, I. (2008). Preparation of derivatives of 1-(2-pyrimidinyl) Piperazine as Potential Antianxiety, Antidepressant, and Antipsychotic Agents. Journal of Heterocyclic Chemistry 45: 1005-1022.
  3. Carta, A., Paglietti, G., Nikookar, M.E.R., Sanna, P., Sechi, L., Zanetti, S. (2002). Novel Substituted Quinoxaline 1,4-dioxides with in vitro Antimycobacterial and Anticandidal Activity. European Journal of Medicinal Chemistry 37(5), 355–366.
  4. Chen, C.Y., Lin, T.P., Chen, C.K., Lin, S.C., Tseng, M.C., Wen, Y.S., Sun, S.S. (2008). New Chromogenic and Fluorescent Probes for Anion Detection: Formation of a [2+2] Supramolecular Complex on Addition of Fluoride with Positive Homotropic Cooperativity. Journal of Organic Chemistry 73(3), 900-911. CLSI. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically Approved Standard, CLSI Document M7-A7, seventhed. (2006). ISBN1-56238-587-9.
  5. El-Faham, A., El-Massry, A.M., Amer, A., Gohar, Y.M. (2002). A Versatile Synthetic Route to Chiral Quinoxaline Derivatives from Aminoacids Precursors. Letters Peptide Science 9(1), 49–54.
  6. El-Sabbagh, OI., El-Sadek, M.E., Lashine, S.M., Yassin, S.H., El-Nabtity, S.M. (2009). Synthesis of new 2(1H)-Quinoxalinone Derivativesfor Antimicrobial and Antiinflammatory Evaluation. Medicinal Chemistry Research 18(9), 782–797.
  7. Ishikawa, H., Sugiyama, T., Kurita, K., Yokoyama, A. (2012). Synthesis and Antimicrobial Activity of 2,3Bis(bromomethyl)quinoxaline Derivatives. Bioorganic Chemistry 41:1–5.
  8. Ishikawa, H., Sugiyama, T., Yokoyama, A. (2013). Synthesis of 2,3bis(halomethyl)quinoxaline Derivatives and Evaluation of Their Antibacterial and Antifungal Activities. Chemical and Pharmaceutical Bulletin 61(4), 438–444.
  9. Kamal, A., Babu, K.S., Faazil, S., Ali Hussaini, S.M., Shaik, A.B. (2014). L-Proline Mediated Synthesis of Quinoxalines; Evaluation of Cytotoxic and Antimicrobial Activity. Royal Society of Chemistry 4(86), 46369–46377.
  10. Khaksar, S., Tajbakhsh, M., Gholami, M., Rostamnezhad, F.A. (2014). Highly efficient Procedure for the Synthesis of Qu