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Journals / The Turkish Journal of Ear Nose and Throat / 2007 / Cilt: 17 - Sayı: 2

Lipid peroxidation and antioxidant levels in patients with laryngeal carcinoma

Larenks karsinomlu hastalarda lipid peroksidasyonu ve antioksidan seviyeleri

Yavuz Fuat YILMAZ
Filiz AKBIYIK
Ümit TUNÇEL
Adnan ÜNAL
Pages
81–84
Publication Date
2007-03-18
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Free radical metabolism may be involved in the pathogenesis of laryngeal cancers.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: Reactive oxygen species ROS play an important role in the pathogenesis of cancer.
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Key Findings & Data:The aim of this study was to investigate the extent of lipid peroxidation and ROS in laryngeal cancer tissues.Patients and Methods: We determined glutathione GSH and malondialdehyde MDA activities as markers of lipid peroxidation in laryngeal tumor spec- imens and tumor-free adjacent tissues of 30 patients with squamous celi carcinoma.Results: Compared to the tumor-free specimens, the level of GSH was significantly low p0.05 .Conclusions: Decreased antioxidant capacity of laryngeal cancer tissues results in elevation of free oxygen radicals and increased lipid peroxida- tion.
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Conclusion & Impact:Free radical metabolism may be involved in the pathogenesis of laryngeal cancers.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Antioksidan/metabolizma · skuamöz hücreli kanser · serbest radikal.

Abstract

Objectives: Reactive oxygen species ROS play an important role in the pathogenesis of cancer. The aim of this study was to investigate the extent of lipid peroxidation and ROS in laryngeal cancer tissues.Patients and Methods: We determined glutathione GSH and malondialdehyde MDA activities as markers of lipid peroxidation in laryngeal tumor spec- imens and tumor-free adjacent tissues of 30 patients with squamous celi carcinoma.Results: Compared to the tumor-free specimens, the level of GSH was significantly low p0.05 .Conclusions: Decreased antioxidant capacity of laryngeal cancer tissues results in elevation of free oxygen radicals and increased lipid peroxida- tion. Free radical metabolism may be involved in the pathogenesis of laryngeal cancers.

Özet

Amaç: Serbest oksijen radikalleri SOR kanser patogenezinde önemli rol oynamaktadır. Bu çalışmadalarengeal kanser dokusunda lipid peroksidasyonu veSOR seviyeleri araştırıldı.Hastalar ve Yöntemler: Larenks skuamöz hücrelikarsinomlu 30 hastada larengeal tümörlü ve tümörsüz dokuda glutatyon GSH ve malondialdehit MDA düzeyleri ve lipid peroksidasyonu değerlerikarşılaştırıldı.Bulgular: Glutatyon seviyesi kanserli dokuda belirgin olarak düşük bulundu p

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Cite This Article

YILMAZ, Y. F., AKBIYIK, F., TUNÇEL, Ü., ÜNAL, A. (2007). Lipid peroxidation and antioxidant levels in patients with laryngeal carcinoma. The Turkish Journal of Ear Nose and Throat, Cilt: 17 - Sayı: 2, 81–84. https://ajindex.com/articles/727162

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