Journals / Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi / 2022 / Cilt: 9 - Sayı: 1

Effect of Selenium and N-Acetyl Cysteine on Fertility/ Infertility and Liver in Obese Rats

Obez Sıçanlarda Selenyum ve N-Asetil Sistein’in Fertilite/ İnfertilite ve Karaciğer Üzerine Etkisi

Pages
1–12
Publication Date
2022-04-29
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In the national and international literature, the therapeutic effects on obese rats were first demonstrated using these agents.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Changing dietary habits and lack of physical activity, which are the returns of modern life, cause obesity to become a public health problem worldwide.
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Key Findings & Data:Various metabolic and systemic diseases develop in obese individuals.
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Conclusion & Impact:In the national and international literature, the therapeutic effects on obese rats were first demonstrated using these agents.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Fertilite · Fertilite · Karaciğer

Abstract

Changing dietary habits and lack of physical activity, which are the returns of modern life, cause obesity to become a public health problem worldwide. Various metabolic and systemic diseases develop in obese individuals. The aim of this study was to evaluate the effects of selenium and N-acetylcysteine treatment on obesity-related liver adiposity and loss of fertility. For this purpose, histochemical and immunohistochemical techniques, as well as serum biochemistry analyzes, oxidative stress parameters and sperm parameters were determined. We found that selenium and N-acetylcysteine reduce the damage caused by obesity on both liver and testis both structurally and biochemically. In the national and international literature, the therapeutic effects on obese rats were first demonstrated using these agents.

Özet

Modern yaşamın getirileri ile beraber değişen beslenme alışkanlıkları ve fiziksel aktivite azlığı, obezitenin dünya genelinde bir halk sağlığı sorunu haline gelmesine neden olmaktadır. Obez bireylerde çeşitli metabolik veya sistemik hastalıklar ortaya çıkmaktadır. Çalışmamızda obeziteye bağlı olarak gelişen karaciğer yağlanması ve fertilite kaybı üzerine selenyum ve N- asetil sistein tedavisinin etkilerini ortaya koymak amaçlanmaktadır. Bu doğrultuda histokimyasal ve immünohistokimyasal tekniklerin yanı sıra serum biyokimya analizleri, oksidatif stres parametreleri ve sperm parametreleri tayinleri yapılmıştır. Selenyum ve N- asetil sisteinin, obezitenin karaciğer ve testis üzerinde oluşturduğu hasarı hem yapısal hem de biyokimyasal düzeyde azalttığını tespit ettik. Ulusal ve uluslararası literatürde ilk kez bu ajanlar kullanılarak obez sıçanlar üzerindeki tedavi edici etkileri gösterilmiştir.

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Cite This Article

BAŞARAN, G., GOKCİMEN, A., CAN, N. K., KABAOĞLU, U. (2022). Effect of Selenium and N-Acetyl Cysteine on Fertility/ Infertility and Liver in Obese Rats. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, Cilt: 9 - Sayı: 1, 1–12. https://ajindex.com/articles/692198

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