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Journals / Journal of Experimental and Clinical Medicine / 2017 / Cilt: 34 - Sayı: 2

Lack of association between IRGM1 (rs13361189), PTGER4 (rs 1373692) and CARD8 (rs 2043211) polymorphism and Behçet’s disease: A study from Turkey

Sibel DOGAN
Basak YALCİN
Nilgun ATAKAN
Ahu YORULMAZ
Ferda ARTUZ
Pages
83–87
Publication Date
2017-09-08
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

CARD8 gene polymorphisms and other in ammasome related genes may play a role in immune pathomechanisms in BD and separate studies including BD patients with similar clinical characteristics are required for investigating different SNPs as a probable disease susceptibility factor.

📌 3 Key Takeaways

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Objective & Hypothesis:Behçet’s disease (BD) is a severe in ammatory vasculitis which is very common among Turkish population.
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Key Findings & Data:Recently, IRGM1 (rs13361189), PTGER4 (rs1373692) and CARD8 (rs2043211) polymorphisms are shown to be associated with several in ammatory diseases.
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Conclusion & Impact:CARD8 gene polymorphisms and other in ammasome related genes may play a role in immune pathomechanisms in BD and separate studies including BD patients with similar clinical characteristics are required for investigating different SNPs as a probable disease susceptibility factor.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Behçet’s disease · CARD8 · IRGM1

Abstract

Behçet’s disease (BD) is a severe in ammatory vasculitis which is very common among Turkish population. Recently, IRGM1 (rs13361189), PTGER4 (rs1373692) and CARD8 (rs2043211) polymorphisms are shown to be associated with several in ammatory diseases. In this study, we investigated the association of IRGM1 (rs13361189), PTGER4 (rs1373692) and CARD8 (rs2043211) polymorphisms with BD and their probable implications on clinical manifestations of BD in a Turkish patient cohort. 116 patients and 150 healthy controls genomic DNA were studied. Allele-speci c primers were used for genotyping. No signi cant difference was found between patient and controls according to genotypic distribution and allelic frequencies of IRGM1 (rs13361189), PTGER4 (rs1373692) and CARD8 (rs2043211) (p>0.05). No statistically signi cant difference was found in genotypic or allellic distribution of the same polymorphisms according to gender or clinical characteristics between patients and controls (p>0.05). Our study is to our knowledge the rst report from Turkey regarding BD and IRGM1 (rs13361189), PTGER4 (rs1373692) and CARD8 (rs2043211) polymorphisms. IRGM gene polymorphisms seems to cause predilection for autoimmunity in certain ethnic groups but not in Turkish BD patients. CARD8 gene polymorphisms and other in ammasome related genes may play a role in immune pathomechanisms in BD and separate studies including BD patients with similar clinical characteristics are required for investigating different SNPs as a probable disease susceptibility factor.

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Cite This Article

DOGAN, S., YALCİN, B., ATAKAN, N., YORULMAZ, A., ARTUZ, F. (2017). Lack of association between IRGM1 (rs13361189), PTGER4 (rs 1373692) and CARD8 (rs 2043211) polymorphism and Behçet’s disease: A study from Turkey. Journal of Experimental and Clinical Medicine, Cilt: 34 - Sayı: 2, 83–87. https://ajindex.com/articles/678321

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References (3)

  1. Ben Hamad, M., Cornelis, F., Marzouk, S., Chabchoub, G., Bahloul, Z., Rebai, A., Fakhfakh, F., Ayadi, H., Petit-Teixeira, E., Maalej, A., 2012. Association study of CARD8 (p.C10X) and NLRP3 (p.Q705K) variants with rheumatoid arthritis in French and Tunisian populations. Int. J. Immunogenet. 39, 131-136. oi: 10.1111/j.1744-313X.2011.01070.x. Carlström, M., Ekman, A.K., Petersson, S., Söderkvist, P., Enerbäck, C., 2012. Genetic support for the role of the NLRP3 in ammasome in psoriasis susceptibility. Exp. Dermatol. 21, 932-937. doi: 10.1111/exd.12049.
  2. Chai, W., Lian, Z., Chen, C., Liu, J., Shi, L.L., Wang, Y., 2013. JARID1A, JMY, and PTGER4 polymorphisms are related to ankylosing spondylitis in chinese han patients: A Case-Control Study. PLoS One. 8, e74794. doi: 10.1371/journal.pone.0074794. Mat, C., Yurdakul, S., Sevim, A., Özyazgan, Y., Tüzün, Y., 2013. Behçet’s syndrome: Facts and controversies. Clin. Dermatol. 31, 352-361. doi: 10.1016/j.clindermatol.2013.01.002. Direskeneli, H., 2006. Autoimmunity vs autoin ammation in Behcet’s disease: Do we oversimplify a complex disorder? Rheumatology (Oxford). 45, 1461-1465. Durães, C., Machado, J.C., Portela, F., Rodrigues, S., Lago, P., Cravo, M., Ministro, P., Marques, M., Cremers, I., Freitas, J., Cotter, J., Tavares, L., Matos, L., Medeiros, I., Sousa, R., Ramos, J., Deus, J., Caldeira, P., Chagas, C., Duarte, M.A., Gonçalves, R., Loureiro, R., Barros, L., Bastos, I., Cancela, E., Moraes, M.C., Moreira, M.J., Vieira, A.I., Magro, F., 2013. Phenotype- genotype pro les in Crohn’s disease predicted by genetic markers in autophagy-related genes (GOIA study II). In amm Bowel Dis. 19, 230-239. doi: 10.1002/ibd.23007. Glas, J., Seiderer, J., Czamara, D., Pasciuto, G., Diegelmann, J., Wetzke, M., Olszak, T., Wolf, C., Müller-Myhsok, B., Balschun, T., Achkar, J.P., Kamboh, M.I., Franke, A., Duerr, R.H., Brand, S., 2012. PTGER4 expression-modulating polymorphisms in the 5p13.1 region predispose to Crohn’s disease and affect NF-κB and XBP1 binding sites. PLoS One. 7, e52873. doi: 10.1371/ journal.pone.0052873. Gül, A., 2001. Behçet’s disease: An update on the pathogenesis. Clin. Exp. Rheumatol. 19, S6-12. Kaneko, F., Togashi, A., Saito, S., Sakuma, H., Oyama, N., Nakamura, K., Yokota, K., Oguma, K., 2011. Behçet’s disease (Adamantiades-Behçet’s disease). Clin. Dev. Immunol. 2011: 681956. doi: 10.1155/2011/681956.
  3. Kaneko, F., Oyama, N., Yanagihori, H., Isogai, E., Yokota, K., Oguma, K., 2008. The role of st