The antiproliferative, apop- totic and necrotic effects of Onobrychis albiflora extract on HCT-116 cells also were determined.
📌 3 Key Takeaways
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Objective & Hypothesis:In this study, the cytotoxic effects of the extracts of methanol: water (80:20) prepared from the above-ground parts of the varieties of Onobrychis albiflora Hub.-Mor., Onobrychis argyrea Boiss. subsp. argyrea, Onobrychis galegifolia Boiss. and Onobrychis tournefortii (Willd.) Desv. species to HCT-116 cells were investigated.
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Key Findings & Data:With cytotoxicity analysis that with these species inhibitor concentrations (IC50) which resulted in a 50% reduction in the proliferation of HCT-116 cells were identified.
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Conclusion & Impact:The antiproliferative, apop- totic and necrotic effects of Onobrychis albiflora extract on HCT-116 cells also were determined.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:HCT-116 · FACS · HEK-293
Abstract
In this study, the cytotoxic effects of the extracts of methanol: water (80:20) prepared from the above-ground parts of the varieties of Onobrychis albiflora Hub.-Mor., Onobrychis argyrea Boiss. subsp. argyrea, Onobrychis galegifolia Boiss. and Onobrychis tournefortii (Willd.) Desv. species to HCT-116 cells were investigated. With cytotoxicity analysis that with these species inhibitor concentrations (IC50) which resulted in a 50% reduction in the proliferation of HCT-116 cells were identified. In continuation of the study; the antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT-116 cells were evaluated by Caspase 3, Annexin V / PI Apoptosis / Necrosis analysis, Apopxin Green and 7-AAD Apoptosis / Necrosis analysis. The antiproliferative, apop- totic and necrotic effects of Onobrychis albiflora extract on HCT-116 cells also were determined.
BÜLBÜL, M. V., ÖZBEK, H., ACIKARA, O. B., OZBILGIN, S., OZ, B. E., KURTUL, E., KESKIN, İ. (2019). Antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT- 116 cells. Journal of Experimental and Clinical Medicine, Cilt: 35 - Sayı: 4, 101–109. https://ajindex.com/articles/678236
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