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Journals / Journal of Basic and Clinical Health Sciences / 2022 / Cilt: 6 - Sayı: 2

The Effect of Quercetin and Quercetin-3-d-xyloside on Breast Cancer Proliferation and Migration

Tuğba Nurcan YÜKSEL
Esra BOZGEYİK
Muhammed YAYLA
Pages
569–578
Publication Date
2022-05-31
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: These results indicated that Reynoutrin markedly inhibit the cell viability in breast cancer.

📌 3 Key Takeaways

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Objective & Hypothesis:Background and Purpose: The aim of this study is to examine the migration, wound healing, colony formation and cytotoxic effects of reynotrin, quercetin derivative, in breast cancer cells.
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Key Findings & Data:Methods: In our study, CRL-4010, MCF7 and MDA-MB-231 cells were used to evaluate the different effects of reynoutrin on breast cancer.
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Conclusion & Impact:Results: These results indicated that Reynoutrin markedly inhibit the cell viability in breast cancer.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Reynoutrin · quercetin · cytotoxicity

Abstract

Background and Purpose: The aim of this study is to examine the migration, wound healing, colony formation and cytotoxic effects of reynotrin, quercetin derivative, in breast cancer cells. Methods: In our study, CRL-4010, MCF7 and MDA-MB-231 cells were used to evaluate the different effects of reynoutrin on breast cancer. The IC50 concentration (400 µg/ml) of reynotrin, quercetin and cisplatin in the cells was determined. For cytotoxicity assessments, varying concentrations of quercetin, reynoutrin and cisplatin were applied and incubated 24h and 48h. In addition, to examine its effects on migration, cells were seeded in 6-well plates and incubated for 24 hours. Morever, to assess colony formation, test cells were seeded in 12-well plates at a concentration of 1000 cells/well and incubated overnight. Results: These results indicated that Reynoutrin markedly inhibit the cell viability in breast cancer. Conclusion: We firstly revealed that Reynoutrin suppressed the progression of breast cancer induction and may provide a potential therapeutic target for breast cancer treatment. More detailed studies are needed to show this effect of reynoutrin.

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Cite This Article

YÜKSEL, T. N., BOZGEYİK, E., YAYLA, M. (2022). The Effect of Quercetin and Quercetin-3-d-xyloside on Breast Cancer Proliferation and Migration. Journal of Basic and Clinical Health Sciences, Cilt: 6 - Sayı: 2, 569–578. https://ajindex.com/articles/677013

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