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Journals / Journal of Basic and Clinical Health Sciences / 2026 / Volume: 10 Issue: 3

Impact of Viral Hepatitis and Thyroid Autoantibodies on Tumor Aggressiveness in Papillary Thyroid Carcinoma

Papiller Tiroid Karsinomunda Viral Hepatitler ve Tiroid Otoantikorlarının Tümör Agresifliği Üzerine Etkisi

Gökçen Güngör Semiz(DOKUZ EYLUL UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-8915-9178
Sabay Akbaş(DOKUZ EYLUL UNIVERSITY, SCHOOL OF MEDICINE)0000-0003-4094-6450
Selda Arslan(DOKUZ EYLUL UNIVERSITY, SCHOOL OF MEDICINE)0009-0004-4210-7348
Şeyhmus Abakay(DOKUZ EYLUL UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-0049-2020
Guljahan Hatamova(DOKUZ EYLUL UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-1372-4978
Ahmet Ömer İkiz(DOKUZ EYLUL UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-1636-9457
Merih Güray Durak(DOKUZ EYLUL UNIVERSITY, SCHOOL OF MEDICINE)0000-0003-3516-952X
Hüseyin Salih Semiz(DOKUZ EYLUL UNIVERSITY, INSTITUTE OF ONCOLOGY)0000-0002-7083-8517
Hülya Ellidokuz(DOKUZ EYLUL UNIVERSITY, INSTITUTE OF ONCOLOGY)0000-0001-8503-061X
Özhan Özdoğan(DOKUZ EYLUL UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-3357-4778
Abdurrahman Çömlekçi(DOKUZ EYLUL UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-3135-2127
Pages
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Publication Date
2026-09-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: Overall, 12 patients (2.3%) were HBsAg-positive and 4 (0.8%) were Anti-HCV-positive.

📌 3 Key Takeaways

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Objective & Hypothesis:Background and Purpose: To evaluate the impact of chronic viral hepatitis (HBV, HCV) and thyroid autoimmunity on the clinicopathological aggressiveness of papillary thyroid carcinoma (PTC).
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Key Findings & Data:Methods: This retrospective study included 521 patients with histologically confirmed PTC.
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Conclusion & Impact:Results: Overall, 12 patients (2.3%) were HBsAg-positive and 4 (0.8%) were Anti-HCV-positive.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Papillary Thyroid Carcinoma · Hepatitis B · Hepatitis C

Abstract

Background and Purpose: To evaluate the impact of chronic viral hepatitis (HBV, HCV) and thyroid autoimmunity on the clinicopathological aggressiveness of papillary thyroid carcinoma (PTC). Methods: This retrospective study included 521 patients with histologically confirmed PTC. Clinicopathological parameters were compared across subgroups stratified by HBV/HCV serostatus, age, gender, and thyroid autoimmunity. Multivariate binary logistic regression was used to identify independent predictors of tumor aggressiveness. Results: Overall, 12 patients (2.3%) were HBsAg-positive and 4 (0.8%) were Anti-HCV-positive. Viral seropositivity was not associated with worse clinicopathological features. In univariate analyses, age 0.05). Conclusion: HBV and HCV seropositivity do not worsen the PTC phenotype. Although younger age and thyroid autoimmunity initially correlated with aggressiveness, neither is an independent predictor. PTC aggressiveness is likely driven by multifactorial variables rather than a single serological marker.

Özet

Giriş ve Amaç: Kronik viral hepatit (HBV, HCV) ve tiroid otoimmünitesinin papiller tiroid karsinomunun (PTC) klinikopatolojik agresifliği üzerindeki etkisini değerlendirmek. Yöntemler: Bu retrospektif çalışmaya histolojik olarak doğrulanmış PTC'si olan 521 hasta dahil edildi. Klinikopatolojik parametreler; HBV/HCV serolojik durumu, yaş, cinsiyet ve tiroid otoimmünitesine göre tabakalandırılmış alt gruplar arasında karşılaştırıldı. Tümör agresifliğinin bağımsız öngörücülerini belirlemek için çok değişkenli ikili lojistik regresyon analizi kullanıldı. Bulgular: Genel olarak, 12 hasta (%2.3) HBsAg pozitif ve 4 hasta (%0.8) Anti-HCV pozitif saptandı. Viral seropozitiflik daha kötü klinikopatolojik özelliklerle ilişkili bulunmadı. Tek değişkenli analizlerde, 0.05). Sonuç: HBV ve HCV seropozitifliği PTC fenotipini kötüleştirmemektedir. Genç yaş ve tiroid otoimmünitesi başlangıçta agresiflikle korelasyon gösterse de, hiçbiri bağımsız bir öngörücü değildir. PTC agresifliği tek bir serolojik belirteçten ziyade büyük olasılıkla çok faktörlü değişkenler tarafından şekillenmektedir.

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Cite This Article

Semiz, G. G., Akbaş, S., Arslan, S., Abakay, Ş., Hatamova, G., İkiz, A. Ö., Durak, M. G., Semiz, H. S., Ellidokuz, H., Özdoğan, Ö., Çömlekçi, A., *, G. G. S. (2026). Impact of Viral Hepatitis and Thyroid Autoantibodies on Tumor Aggressiveness in Papillary Thyroid Carcinoma. Journal of Basic and Clinical Health Sciences, Volume: 10 Issue: 3. https://doi.org/10.30621/jbachs.2010338

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