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Journals / İstanbul Journal of Pharmacy / 2021 / Cilt: 51 - Sayı: 2

Effects of chlorpyrifos-methyl, chlormequat, deltamethrin, glyphosate, pirimiphos-methyl, tebuconazole and their mixture on oxidative stress and toxicity in HUVEC cell line

Çiğdem SEVİM
Ali TAGHİZADEHGHALEHJOUGHİ
Mehtap KARA
Pages
183–190
Publication Date
2021-08-31
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The findings are that pesticide mixture exposure might have an impact on human health risk at contaminated sites and under occupational exposure conditions.

📌 3 Key Takeaways

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Objective & Hypothesis:Background and Aims: Humans and animals have daily contact with various chemicals, including food additives, pesticides, antibiotics, other veterinary drugs, and other xenobiotics.
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Key Findings & Data:Results: In this study, the mixtures of pesticides reduced total antioxidant status (TAS) and GSH level one by one and increased the reactive oxygen species (ROS) generation in HUVECs, respectively.
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Conclusion & Impact:Conclusion: The findings are that pesticide mixture exposure might have an impact on human health risk at contaminated sites and under occupational exposure conditions.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Chlorpyrifos-methyl · chlormequat · deltamethrin

Abstract

Background and Aims: Humans and animals have daily contact with various chemicals, including food additives, pesticides, antibiotics, other veterinary drugs, and other xenobiotics. Pesticide exposure causes many health disorders. Mixed exposure to pesticides is an important issue for human and environmental health. Methods: In this study, we have determined the cytotoxicity of chlormequat pirimiphos-methyl, glyphosate, tebuconazole, chlorpyrifos-methyl, deltamethrin, and the mixture of these six pesticides. We further investigated the role of oxidative stress, total oxidant status (TOS), lactate dehydrogenase (LDH) and antioxidant defense mechanism TOS, total glutathione (GSH) levels with the observed cytotoxicity. Results: In this study, the mixtures of pesticides reduced total antioxidant status (TAS) and GSH level one by one and increased the reactive oxygen species (ROS) generation in HUVECs, respectively. The results also showed a significant contribution of oxidative stress on cytotoxicity during pesticide mixture exposure. Conclusion: The findings are that pesticide mixture exposure might have an impact on human health risk at contaminated sites and under occupational exposure conditions.

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Cite This Article

SEVİM, Ç., TAGHİZADEHGHALEHJOUGHİ, A., KARA, M. (2021). Effects of chlorpyrifos-methyl, chlormequat, deltamethrin, glyphosate, pirimiphos-methyl, tebuconazole and their mixture on oxidative stress and toxicity in HUVEC cell line. İstanbul Journal of Pharmacy, Cilt: 51 - Sayı: 2, 183–190. https://ajindex.com/articles/676251

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