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Journals / İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi / 2020 / Sayı: 11

Investigation of Neuroprotective Effect of Genistein in Experimental Spinal Cord Injury Model in Rats, Evaluation with Diffuse Tensor Imaging

Ratlarda Deneysel Spinal Kord Hasar Modelinde Genisteinin Nöroprotektif Etkisinin Araştırılması, Diffüz Tensor Görüntüleme ile Değerlendirilmesi

Gülşah ÖZTÜRK
Gökalp SİLAV
Said İNCİR
Ayça ARSLANHAN
Mustafa Ali AKÇETİN
Orkun Zafer TOKTAŞ
Deniz KONYA
Pages
130–149
Publication Date
2020-08-31
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this study, we aimed to explore the effectiveness of Genistein (GEN), a phytoestrogen and tyrosine kinase inhibitor in a rat thoracic weight drop SCI model and to evaluate the long term results with diffusion tensor imaging (DTI), locomotion and histopathological changes.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Spinal cord injury (SCI) is a wide spectrum of a devastating disease which has significant effects on individuals, families or society even though the incidence is low.
📊
Key Findings & Data:Studies on neural tissue repair have huge progress in recent years but spinal cord injury still remains a troublesome condition with no definitive cure.
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Conclusion & Impact:In this study, we aimed to explore the effectiveness of Genistein (GEN), a phytoestrogen and tyrosine kinase inhibitor in a rat thoracic weight drop SCI model and to evaluate the long term results with diffusion tensor imaging (DTI), locomotion and histopathological changes.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:diffuz tensor görüntüleme · spinal kord hasarı · genistein

Abstract

Aim: Spinal cord injury (SCI) is a wide spectrum of a devastating disease which has significant effects on individuals, families or society even though the incidence is low. Studies on neural tissue repair have huge progress in recent years but spinal cord injury still remains a troublesome condition with no definitive cure. In this study, we aimed to explore the effectiveness of Genistein (GEN), a phytoestrogen and tyrosine kinase inhibitor in a rat thoracic weight drop SCI model and to evaluate the long term results with diffusion tensor imaging (DTI), locomotion and histopathological changes.

Özet

Amaç: Spinal kord hasarı (SKH), insidansı çok yüksek olmamasına rağmen, bu durumun sonuçları birey, aile ve toplum için son derece önemli sekellerle sonuçlanabilecek bir hastalıktır. Nöral hasar onarımı ile ilgili her geçen gün yeni çalışmalar umut vadetmekle birlikte SKH için kür olabilecek altın standart bir tedavi henüz yoktur. Bu çalışmada ratlarda ağırlık düşürme modeli kullanılarak oluşturulan spinal kord hasarı sonrası tedavi amaçlı verilen; bir tirozinkinaz inhibitörü olan Genistein (GEN) isimli fitoöstrojenin etkisi araştırılmış ve geç dönemde sayılı rat üzerindeki diffüzyon tensör görüntüleme (DTG) ile sonuçları değerlendirilmiştir.

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Cite This Article

ÖZTÜRK, G., SİLAV, G., İNCİR, S., ARSLANHAN, A., AKÇETİN, M. A., TOKTAŞ, O. Z., KONYA, D. (2020). Investigation of Neuroprotective Effect of Genistein in Experimental Spinal Cord Injury Model in Rats, Evaluation with Diffuse Tensor Imaging. İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi, Sayı: 11, 130–149. https://ajindex.com/articles/675981

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