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Journals / Journal of Basic and Clinical Health Sciences / 2022 / Cilt: 6 - Sayı: 3

Effects of Chromosomal Translocations on Sperm Count in Azoospermic and Oligospermic Cases

Akif AYAZ
Sinem YALÇINTEPE
Özge ÖZALP YÜREĞİR
Elif YILMAZ GÜLEÇ
Alper GEZDİRİCİ
Ebru PERİM AKÇAY
Abdullah Hüseyin KÖSEOĞLU
Yavuz ŞAHİN
Pages
921–927
Publication Date
2022-09-29
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The results also showed the importance of genetic counselling in patients with translocations.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose A number of mechanisms have been proposed for the effect of chromosomal translocations on spermatogenesis and sperm maturation.
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Key Findings & Data:Material and Methods The study was conducted on the data of 16 male patients with reciprocal or Robertsonian translocation among 152 patients who were admitted to Adana Numune Training and Research Hospital and Kanuni Sultan Süleyman Training and Research Hospital Genetic Diagnosis Centers between 2013 and 2016 due to azoospermia and oligospermia.
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Conclusion & Impact:The results also showed the importance of genetic counselling in patients with translocations.
🔬Design:Research Article
📍Scope:2013 Verileri
⚙️Variables:Azospermia · Oligospermia · Reciprocal

Abstract

Purpose A number of mechanisms have been proposed for the effect of chromosomal translocations on spermatogenesis and sperm maturation. However, there are still numerous ambiguous issues regarding these two processes. The aim of this study is to evaluate the effect of chromosome break areas on sperm count in the light of the literature. Material and Methods The study was conducted on the data of 16 male patients with reciprocal or Robertsonian translocation among 152 patients who were admitted to Adana Numune Training and Research Hospital and Kanuni Sultan Süleyman Training and Research Hospital Genetic Diagnosis Centers between 2013 and 2016 due to azoospermia and oligospermia. Results 11 of these patients had reciprocal and five patients had Robertsonian translocations. All the patients with Robertsonian translocations were detected with azoospermia. Of the patients with reciprocal translocation, five of them were azoospermic and six of them were severe oligospermic. Conclusion A total of 21 chromosomal breakpoints were identified in the 11 patients with reciprocal translocations. These chromosomal breakpoints may contribute to the clarification of ambiguous issues related to spermatogenesis and sperm maturation. The results also showed the importance of genetic counselling in patients with translocations.

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Cite This Article

AYAZ, A., YALÇINTEPE, S., YÜREĞİR, Ö. Ö., GÜLEÇ, E. Y., GEZDİRİCİ, A., AKÇAY, E. P., KÖSEOĞLU, A. H., ŞAHİN, Y. (2022). Effects of Chromosomal Translocations on Sperm Count in Azoospermic and Oligospermic Cases. Journal of Basic and Clinical Health Sciences, Cilt: 6 - Sayı: 3, 921–927. https://ajindex.com/articles/675401

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References (15)

  1. REFERENCES 1. World Health Organization (2000) WHO Manual for the Standardised Investigation and Diagnosis of the Infertile Couple, Cambridge: Cambridge University Press. 2. Bhasin S, de Kretser DM, Baker HW: Clinical review 64: Pathophysiology and natural history of male infertility. J Clin Endocrinol Metab 1994
  2. 1525 – 1529. 3. Gurunath S, Pandian Z, Anderson RA, Bhattacharya S. Defining infertility – a systematic review of prevalence studies. Hum Reprod Update. 2011
  3. 575–88. 4. Kosar PA, Ozcelik N, Kosar A. Cytogenetic abnormalities detected in patients with non-obstructive azoospermia and severe oligozoospermia. J Assist Reprod Genet. 2010
  4. 17–21. 5. Dohle GR, Halley DJ, Van Hemel JO, van den Ouwel AM, Pieters MH et al. Genetic risk factors in infertile men with severe oligozoospermia and azoospermia. Hum Reprod. 2002
  5. 13–6. 6. Martin RH. Cytogenetic determinants of male fertility. Hum Reprod Updat. 2008
  6. 379–90. 7. Ceylan GG, Ceylan C, Elyas H. Genetic anomalies in patients with severe oligozoospermia and azoospermia in eastern Turkey: a prospective study. Genet Mol Res. 2009
  7. 915–22. 8. Zhou-Cun A, Yang Y, Zhang SZ, Zhang W, Lin L. Chromosomal abnormality and Y chromosome microdeletion in Chinese patients with azoospermia or severe oligozoospermia. Yi Chuan Xue Bao. 2006
  8. 111–16. 9. Chiang HS, Wei HJ, Chen YT. Genetic screening for patients with azoospermia and severe oligo-asthenospermia. Int J Androl. 2000
  9. 20–5. 10. Ng PP, Tang MH, Lau ET, Ng LK, Ng EH et al. Chromosomal anomalies and Y-microdeletions among Chinese subfertile men in Hong Kong. Hong Kong Med J. 2009
  10. 31–8. 11. Nagvenkar P, Desai K, Hinduja I, Zaveri K. Chromosomal studies in infertile men with oligozoospermia & non-obstructive azoospermia. Indian J Med Res. 2005
  11. 34–42. 12. Balkan M, Tekes S, Gedik A. Cytogenetic and Y chromosome microdeletion screening studies in infertile males with oligozoospermia and azoospermia in Southeast Turkey. J Assist Reprod Genet. 2008
  12. 559–65. 13. Van Assche E, Bonduelle M, Tournaye H, Joris H, Verheyen G, et al: Cytogenetics of infertile men. Hum Reprod 1996
  13. 11(suppl 4): 1 – 26. 14. Baker HW: Clinical approach to molecular genetic diagnosis in andrology
  14. in Robaire B, Chemes H, Morales CR (eds): Andrology in the 21th century. Englewood NJ, Medimond, 2001, pp373–382. 15. McLachlan RI, O’Bryan MK: State of the art for genetic testing of infertile men. J Clin EndocrinolMetab 2010
  15. 1013–1024. 16. Kara M, Sen A, Cetin ES and Karg