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Journals / Etlik Veteriner Mikrobiyoloji Dergisi / 2022 / Cilt: 33 - Sayı: 1

Protective Effect of Silymarin and Boric Acid Against Isoproterenol-Induced Myocardial Infarction in Mice

Farelerde İzoproterenol ile İndüklenmiş Miyokard İnfarktüsüne Karşı Silimarin ve Borik Asidin Koruyucu Etkisi

Yaşar ŞAHİN
Mehmet Eray ALÇIĞIR
Filiz BAKAR ATEŞ
Hüsamettin EKİCİ
Ali ŞENOL
Enes Gazi ATICI
Ebru YILDIRIM
Siyami KARAHAN
Pages
26–33
Publication Date
2022-06-15
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The CK level was found to be significantly lower in the GIII and GV groups compared to the GII group (P

📌 3 Key Takeaways

🎯
Objective & Hypothesis:This study aimed to compare the protective or therapeutic effects of silymarin and/or boric acid against myocardial infarction induced by isoproterenol.
📊
Key Findings & Data:The GIII group was received silymarin (100mg/kg), while the GIV group was given boric acid (100mg/kg) for 14 days.
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Conclusion & Impact:The CK level was found to be significantly lower in the GIII and GV groups compared to the GII group (P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Borik asit · İzoproteranol · Kreatin kinaz

Abstract

This study aimed to compare the protective or therapeutic effects of silymarin and/or boric acid against myocardial infarction induced by isoproterenol. Distilled water was given orally by gavage to the GI and GII groups for fourteen days. The GIII group was received silymarin (100mg/kg), while the GIV group was given boric acid (100mg/kg) for 14 days. In the last group, both silymarin and boric acid were given orally (gavage) for fourteen days. On the thirteenth and fourteenth days of the study, while isotonic water was applied to the GI group, isoproterenol (85mg/kg) was applied to the other groups subcutaneously. Plasma ALT, AST, Ca, CK, CHO, TP, Ing P, IL-6, IL-12, PAL-1, and sPLA2 parameters were evaluated. Histopathological examination was performed on the heart, lung, liver, kidney, spleen, cerebrum, and cerebellum tissues taken from mice. The CK level was found to be significantly lower in the GIII and GV groups compared to the GII group (P

Özet

Bu çalışmada izoproterenol ile oluşturulan miyokard infarktüsüne karşı silimarin ve/veya borik asidin koruyucu veya tedavi edici etkilerinin karşılaştırılması amaçlanmıştır. GI ve GII gruplarına on dört gün boyunca gavaj ile oral yolla distile su verildi. On dört gün boyunca; GIII grubuna silimarin (100mg/kg) verilirken GIV grubuna borik asit (100mg/kg) verildi. Son gruba ise hem silimarin hem de borik asit on dört gün boyunca oral yolla (gavaj) verildi. Çalışmanın on üçüncü ve on dördüncü günü intraperitoneal yolla; GI grubuna izotonik uygulanırken, diğer gruplara subkutan izoproteranol (85mg/kg) uygulandı. Plazmadan; ALT, AST, Ca, CK, CHO, TP, Ing P, IL-6, IL-12, PAL-1 ve sPLA2 parametreleri değerlendirildi. Farelerden alınan kalp, akciğer, karaciğer, böbrek, dalak, cerebrum ve cerebellum dokularında histopatolojik inceleme yapıldı. CK düzeyi GII grubuna göre GIII grubunda anlamlı düzeyde azaldığı bulundu (P

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Cite This Article

ŞAHİN, Y., ALÇIĞIR, M. E., ATEŞ, F. B., EKİCİ, H., ŞENOL, A., ATICI, E. G., YILDIRIM, E., KARAHAN, S. (2022). Protective Effect of Silymarin and Boric Acid Against Isoproterenol-Induced Myocardial Infarction in Mice. Etlik Veteriner Mikrobiyoloji Dergisi, Cilt: 33 - Sayı: 1, 26–33. https://ajindex.com/articles/664975

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References (8)

  1. Abbas AM. (2016) Cardioprotective effect of resveratrol analogue isorhapontigenin versus omega-3 fatty acids in isoproterenol-induced myocardial infarction in rats. J Physiol Biochem. 72, 469-484.
  2. Chambers CS, Holečková V, Petrásková L, Biedermann D, Valentová K, Buchta M, Křen V. (2017) The silymarin composition… and why does it matter???. Food Res Int. 100(3), 339-353. De Sánchez CV, Yañez-Maldonado L, Vidrio-Gómez S et al. Role of nitric oxide in isoproterenol-induced myocardial infarction. In: Fiuza M (Ed.). Cardiotoxicity of Oncologic Treatments, IntechOpen, 2012, DOI: 10.5772/34505. Devirian TA, Volpe SL. (2003) The physiological effects of dietary boron. Crit Rev Food Sci Nutr. 43(2), 219-231.
  3. Devrim AK, Sozmen M, Devrim T, Sudagidan M, Cinar M, Kabak YB. (2014) Periostin normalizes levels of cardiac markers in rats with experimental isoproterenol cardiotoxicity. Bratisl Lek Listy. 2017; 118(11): 705-709. Ekor M. The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol. 4, 177. Karimkhani H, Özkoç M, Shojaolsadati P, Uzuner K, Donmez DB, Kanbak G. (2021) Protective Effect of Boric Acid and Omega-3 on Myocardial Infarction in an Experimental Rat Model. Biol Trace Elem Res. 199(7), 2612-2620.
  4. Karthick M, Stanely Mainzen Prince P. (2006) Preventive effect of rutin, a bioflavonoid, on lipid peroxides and antioxidants in isoproterenol-induced myocardial infarction in rats. J Pharm Pharmacol. 58(5), 701-707.
  5. Lalitha G, Poornima P, Archanah A, Padma VV. (2013) Protective effect of neferine against isoproterenol-induced cardiac toxicity. Cardiovasc Toxicol. 13(2), 168-179.
  6. Liu C, Huang Y. (2016) Chinese Herbal Medicine on Cardiovascular Diseases and the Mechanisms of Action. Front Pharmacol. 7, 469. Lu L, Liu M, Sun R, Zheng Y, Zhang P. (2015) Myocardial Infarction: Symptoms and Treatments. Cell Biochem Biophys. 72(3), 865-867. Luna LG. Manual of histologic staining methods of the armed forces ınstitute of pathology. 3rd Ed., McGraw-Hill, New York, USA. 1968.
  7. MacDonald-Ramos K, Michán L, Martínez-Ibarra A, Cerbón M. (2021) Silymarin is an ally against insulin resistance: A review. Ann Hepatol. 23, 100255. Mathew S, Menon PV, Kurup PA. (1985) Effect of administration of vitamin A, ascorbic acid and nicotinamide adenine dinucleotide + flavin adenine dinucleotide on severity of myocardial infarction induced by isoproterenol in rats. Indian J Exp Biol. 23(9), 500-504.
  8. McCullough ML, Peterson