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Journals / Dicle Üniversitesi Veteriner Fakültesi Dergisi / 2017 / Cilt: 10 - Sayı: 2

The Distribution of Vascular Endothelial Growth Factor and its Receptors in Avian Proventriculus

Kanatlı Proventrikulusunda Vasküler Endotel Büyüme Faktörü ve Reseptörlerinin Dağılımı

Hakan SAĞSÖZ
Berna GÜNEY SARUHAN
Mehmet Erdem AKBALIK
Uğur TOPALOĞLU
Muzaffer Aydın KETANİ
Pages
122–129
Publication Date
2017-12-25
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As a result, it is thought that VEGF and its receptors may play a critical role in the proliferation, differentiation, apoptosis and angiogenesis of non-endothelial cells in the avian proventriculus.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study, to gain a better understanding of the physiological roles of vascular endothelial growth factor (VEGF) and its receptors (flt1/fms, flk1/KDR), in the avian proventriculus were examined cellular localizations by immunohistochemistry.
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Key Findings & Data:For this study, 10 avian (5 males and 5 females) were used.
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Conclusion & Impact:As a result, it is thought that VEGF and its receptors may play a critical role in the proliferation, differentiation, apoptosis and angiogenesis of non-endothelial cells in the avian proventriculus.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:flt1/fms · proventrikulus · tavuk

Abstract

In this study, to gain a better understanding of the physiological roles of vascular endothelial growth factor (VEGF) and its receptors (flt1/fms, flk1/KDR), in the avian proventriculus were examined cellular localizations by immunohistochemistry. For this study, 10 avian (5 males and 5 females) were used. Tissue samples from proventriculus were fixed in 10% formol-alcohol for routine histological processing. Positive immunoreaction for VEGF and its receptors was determined in the luminal and gland epithelial cells, stromal, smooth muscle cells and endothelial and smooth muscle cells of blood vessels in the avian proventriculus. However, it was determined that VEGF and its receptors showed a very strong cytoplasmic expression in glandular epithelial cells. As a result, it is thought that VEGF and its receptors may play a critical role in the proliferation, differentiation, apoptosis and angiogenesis of non-endothelial cells in the avian proventriculus.

Özet

Bu çalışmada kanatlı proventrikuluslarında vasküler endotelyal büyüme faktörü (VEGF) ve reseptörlerinin (flt1/fms, flk1/KDR) fizyolojik rollerini daha iyi anlamak için, immünohistokimya kullanılarak hücresel lokalizasyonları incelendi. Çalışmanın materyalini 10 adet (5 erkek ve 5 dişi) tavuk oluşturdu. Proventrikulustan elde edilen doku örnekleri rutin histolojik işlemler için % 10 formol-alkolde tespit edildi. Kanatlı proventrikuluslarında luminal ve bez epitel hücreleri, stromal ve düz kas hücreleri ile damarların endotel ve düz kas hücrelerinin VEGF ve reseptörleri için pozitif immunreaksiyon gösterdiği belirlendi. Bununla birlikte VEGF ve reseptörlerinin bez epitel hücrelerinde daha güçlü sitoplazmik bir ekspresyon gösterdiği saptandı. Sonuç olarak VEGF ve reseptörlerinin kanatlı proventrikulusundaki non-endotelyal hücrelerde çoğalma, farklılaşma, apopitozis ve anjiogenezisin sağlanmasında kritik bir rolünün olabileceği düşünülmüştür.

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Cite This Article

SAĞSÖZ, H., SARUHAN, B. G., AKBALIK, M. E., TOPALOĞLU, U., KETANİ, M. A. (2017). The Distribution of Vascular Endothelial Growth Factor and its Receptors in Avian Proventriculus. Dicle Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 10 - Sayı: 2, 122–129. https://ajindex.com/articles/656516

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References (14)

  1. Nasrin M, Siddiqi MNH, Masum MA, Wares MA. (2012). Gross and Histological Studies of Digestive Tract of Broilers during Postnatal Growth and Development. J Bangladesh Agril Univ. 10 (1): 69-77
  2. De Verdal H, Mignon-Grasteau S, Jeulin C, et al. (2010). Digestive Tract Measurements and Histological Adaptation in Broiler Lines Divergently Selected for Digestive Efficiency. Poultry Sci. 89: 1955-1961
  3. Liman N, Alan E, Kücükbayram G. (2010). The Differences between the Localizations of MUC1, MUC5AC, MUC6 and Osteopontin in Quail Proventriculus and Gizzard may be a Reflection of Functional Differences of Stomach Parts. J Anat. 217: 57-66
  4. Tanyolaç A. (1993). Özel Histoloji. R Demir (editör). Palme Yayıncılık, Ankara
  5. Erdogan S, Sagsoz H, Akbalik ME. (2012). Anatomical and Histological Structure of the Tongue and Histochemical Characteristics of the Lingual Salivary Glands in the Chukar Partridge (Alectoris chukar, Gray 1830). Brit Poultry Sci. 53: 307-315
  6. Erdogan S, Iwasaki S. (2014). Function-related Morphological Characteristics and Specialized Structures of the Avian Tongue. Ann Anat. 196: 75-87
  7. Sagsoz H, Erdogan S, Akbalik ME. (2013). Histomorphological Structure of the Palate and Histochemical Profiles of the Salivary Palatine Glands in the Chukar partridge (Alectoris chukar, Gray 1830). Acta Zool-Stockholm. 94: 382-391
  8. Ferrara N, Gerber HP, Le Couter J. (2003). The Biology of VEGF and its Receptors. Nat Med. 9: 669-676
  9. Takahashi RI, Tanaka S, Kitadai Y et al. (2003). Expression of Vascular Endothelial Growth Factor and Angiogenesis in Gastrointestinal Stromal Tumor of the Stomach. Oncology-Basel. 64 (3): 266-274
  10. Zhang HI, Wu J, Meng L, Shou CC. (2002). Expression of Vascular Endothelial Growth Factor and its Receptors KDR and Flt-1 in Gastric Cancer Cells. World J Gastroentero. 8 (6): 994-998
  11. Raica MI, Mogoantă L, Cîmpean AM et al. (2008). Immunohistochemical Expression of Vascular Endothelial Growth Factor (VEGF) in Intestinal Type Gastric Carcinoma. Rom J Morphol Embryo. 49 (1): 37-42
  12. Yamamoto S, Yasui W, Kitadai Y et al. (1998). Expression of Vascular Endothelial Growth Factor in Human Gastric Carcinomas. Pathol Int. 48: 499-506
  13. Xiaoxiang LI, Zhenwei JI, Yunlei MA et al. (2012). Expression of Hypoxia-Inducible Factor-1α, Vascular Endothelial Growth Factor and Matrix Metalloproteinase-2 in Sacral Chordomas. Oncol Lett. 3 (6): 1268-1274
  14. Aitkenhead M, Christ B, Eichmann A et al. (1998). Paracrine and A