Journals / Türk Nefroloji Diyaliz ve Transplantasyon Dergisi / 2015 / Cilt: 24 - Sayı: 2

Nefrotik Sendromlu Hastalarda Proteinüri ve İdrar Anjiyotensinojen Düzeyleri Arasındaki İlişki

The Relationship Between Proteinuria and Urinary Angiotensinogen Levels in Patients with Nephrotic Syndrome Nefrotik Sendromlu Hastalarda Proteinüri ve İdrar Anjiyotensinojen

Pages
195–201
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The patients diagnosed with vasculitis, lupus nephritis, diabetes mellitus or amyloidosis, those with a glomerular filtration rate (GFR)

📌 3 Key Takeaways

🎯
Objective & Hypothesis:OBJECTIVE: Recently, urinary angiotensinogen (AGT) is used frequently as a marker of intrarenal renin-angiotensin-aldosterone system (RAAS) activity.
📊
Key Findings & Data:In this study, we aimed to investigate the relationship between urinary AGT and proteinuria in patients with nephrotic syndrome.
💡
Conclusion & Impact:The patients diagnosed with vasculitis, lupus nephritis, diabetes mellitus or amyloidosis, those with a glomerular filtration rate (GFR)
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

OBJECTIVE: Recently, urinary angiotensinogen (AGT) is used frequently as a marker of intrarenal renin-angiotensin-aldosterone system (RAAS) activity. In this study, we aimed to investigate the relationship between urinary AGT and proteinuria in patients with nephrotic syndrome. MATERIAL and METHODS: Twenty-four patients followed up with nephrotic syndrome were included. The patients diagnosed with vasculitis, lupus nephritis, diabetes mellitus or amyloidosis, those with a glomerular filtration rate (GFR)

Özet

Öz AMAÇ: Son yıllarda idrar anjiyotensinojen (AGT) düzeyi, intrarenal renin-anjiyotensin-aldosteron sistemi (RAAS) aktivitesinin göstergelerinden birisi olarak sıkça kullanılmaktadır. Biz çalışmada nefrotik sendromlu hastalarda idrar AGT ve proteinüri düzeyi arasındaki ilişkiyi incelemeyi amaçladık. GEREÇ ve YÖNTEMLER: Çalışmaya nefrotik sendromlu 24 hasta dahil edildi. Vaskülit, lupus nefriti, diyabetes mellitus veya amiloidoz tanılı, glomerüler filtrasyon hızı (GFH)

🔖

Cite This Article

ATEŞ, İ., ÖZKAYAR, N., TURHAN, T., BAYRAKÇI, N., DEDE, F. (2022). Nefrotik Sendromlu Hastalarda Proteinüri ve İdrar Anjiyotensinojen Düzeyleri Arasındaki İlişki. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, Cilt: 24 - Sayı: 2, 195–201. https://ajindex.com/articles/655002

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Guyton AC: Blood pressure control-special role of the kidneys and body fluids. Science 1991
  2. 252(5014):1813-1816 2. Floege Jr, Johnson RJ, Feehally J: Comprehensive Clinical Nephrology (4th ed). Philadelphia, PA: Saunders/Elsevier, 2010 3. Kobori H, Nangaku M, Navar LG, Nishiyama A: The intrarenal renin-angiotensin system: From physiology to the pathobiology of hypertension and kidney disease. Pharmacological Reviews 2007
  3. 59(3):251-287 4. He FJ, MacGregor GA: Salt, blood pressure and the renin- angiotensin system. JRAAS 2003
  4. 4(1):11-16 5. Guyton AC: Abnormal renal function and autoregulation in essential hypertension. Hypertension 1991
  5. III49-53 6. Navar LG, Imig JD, Zou L, Wang CT: Intrarenal production of angiotensin II. Semin Nephrol 1997
  6. 17(5):412-422 7. Moulik S, Speth RC, Turner BB, Rowe BP: Angiotensin II receptor subtype distribution in the rabbit brain. Exp Brain Res 2002
  7. 142(2):275-283 8. Yamada M, Kushibiki M, Osanai T, Tomita H, Okumura K: Vasoconstrictor effect of aldosterone via angiotensin II type 1 (AT1) receptor: Possible role of AT1 receptor dimerization. Cardiovasc Res 2008
  8. 79(1):169-178 9. van Kats JP, Danser AH, van Meegen JR, Sassen LM, Verdouw PD, Schalekamp MA: Angiotensin production by the heart: A quantitative study in pigs with the use of radiolabeled angiotensin infusions. Circulation 1998
  9. 98(1):73-81 10. Wagner J, Jan Danser AH, Derkx FH, de Jong TV, Paul M, Mullins JJ, Schalekamp MA, Ganten D: Demonstration of renin mRNA, angiotensinogen mRNA, and angiotensin converting enzyme mRNA expression in the human eye: Evidence for an intraocular renin-angiotensin system. Br J Ophthalmol 1996
  10. 80(2):159-163 11. Karlsson C, Lindell K, Ottosson M, Sjostrom L, Carlsson B, Carlsson LM: Human adipose tissue expresses angiotensinogen and enzymes required for its conversion to angiotensin II. J Clin Endocrinol Metab 1998
  11. 83(11):3925-3929 12. Rohrwasser A, Morgan T, Dillon HF, Zhao L, Callaway CW, Hillas E, Zhang S, Cheng T, Inagami T, Ward K, Terreros DA, Lalouel JM: Elements of a paracrine tubular renin-angiotensin system along the entire nephron. Hypertension 1999
  12. 34(6):1265-1274 13. Nakano D, Kobori H, Burford JL, Gevorgyan H, Seidel S, Hitomi H, Nishiyama A, Peti-Peterdi J: Multiphoton imaging of the glomerular permeability of angiotensinogen. J Am Soc Nephrol 2012
  13. 23(11):1847-1856 14. Pohl M, Kaminski H, Castrop H, Bader M, Himmerkus N, Bleich M, Bachmann S, Theilig F: Intrarenal renin angiotensin system revisited: Role of megalin-de