Azetidinon Payı Taşıyan Mannik Bazların Sentezi ve Tıbbi Değerlendirmesi

Objective & Hypothesis:Aim: To synthesize, characterize and in vitro screen for antibacterial, antifungal and anthelmintic activity of series of Mannich bases carrying azetidinone moiety.

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Key Findings & Data:Material and Method: The compounds were characterized by IR, 1H NMR and mass spectra and by elemental analysis.

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Conclusion & Impact:Further, the compound 7h with N-methylpiperazine substituent showed anthelmintic activity comparable to that of the standard drug.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Aim: To synthesize, characterize and in vitro screen for antibacterial, antifungal and anthelmintic activity of series of Mannich bases carrying azetidinone moiety. Material and Method: The compounds were characterized by IR, 1H NMR and mass spectra and by elemental analysis. Their antimicrobial activity against the selected microorganism was found out by disk diffusion method. Anthelmintic activity studies were performed on Pheretima posthuma. Results: The antibacterial activity of the title compounds was compared with that of ciprofloxacin, antifungal activity with clotrimazole and anthelmintic activity was compared with that of piperazine citrate. Discussion: All the compounds showed significant antimicrobial activity in particular, the activity of compounds 7c, 7e, 7f and 7h was comparable to that of standard antibiotics employed in the studies. Further, the compound 7h with N-methylpiperazine substituent showed anthelmintic activity comparable to that of the standard drug.

Özet

Amaç: Azatidinon payı taşıyan Mannik bazlar serisini sentezlemek ve antibakteriyel, antifungal, antihelmintik activitilerini in vitro olarak taramak ve karakterize etmek. Gereç ve Yöntem: Paylar IR, 1H NMR ve kitle spektra ile ve elemental analiz ile karakterize edildiler. Seçilen ajana yönelik antimikrobiyal aktiviteleri disk difüzyon yöntemi ile tespit edildi. Antihelmintik aktivite çalışmaları Pheretima posthuma ile gerçekleştirildi. Bulgular: Maddelerin antimikrobiyal aktiviteleri siprofloksasin aktivitesi ile antifungal aktiviteleri klotrimazol aktivitesi ile ve antihelmintik aktiviteleri piperazin sitrat ile karşılıştırıldı. Tartışma: Tüm maddelerin antimikrobiyal aktivite gösterdiği izlenirken özellikle 7c, 7e, 7f ve 7h ürünlerinin aktiviteleri çalışmada uygulanan standart antibiyotiklerle karşılaştırılabilir idi. Ayrıca, N-metilpiperazin parçası içeren madde 7h standart ilaç ile karşılaştırılabilir antihelmintik aktivite göstermiştir.

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Cite This Article

RAJU, K. R., KUMAR, B. S., RAVİNDRANATH, L. R. K. R., PRASAD2, A. R. G. (2022). Azetidinon Payı Taşıyan Mannik Bazların Sentezi ve Tıbbi Değerlendirmesi. Journal of Clinical and Analytical Medicine, Cilt: 6 - Sayı: 6, 720–725. https://ajindex.com/articles/652350

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