Journals / Gülhane Askeri Tıp Akademisi Bülteni / 1997 / Cilt: 39 - Sayı: 1

Serum interleukin-6 levels in patients with malignant lymphoma

Malign lenfomada serum interlökin-6'nın değeri

Pages
15–19
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Serum IL-6 levels were not significatly .different in patients with and without systemic "B" symptoms (weight loss, fever and night sweats) in the different histologic subtypes and clinical stages.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:lnterleukin-6 (IL-6) is a potent immunomodulatory cytokine that may have pathogenetic and prognostic significance in a number of disorders.
📊
Key Findings & Data:In this study, we measured serum IL-6 levels in 20 patients with malignant lymphoma (10 patients with Hodgkin's disease, 10 patients with non-Hodgkin's lymphoma) and 12 healthy volunteers.
💡
Conclusion & Impact:Serum IL-6 levels were not significatly .different in patients with and without systemic "B" symptoms (weight loss, fever and night sweats) in the different histologic subtypes and clinical stages.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

lnterleukin-6 (IL-6) is a potent immunomodulatory cytokine that may have pathogenetic and prognostic significance in a number of disorders. In this study, we measured serum IL-6 levels in 20 patients with malignant lymphoma (10 patients with Hodgkin's disease, 10 patients with non-Hodgkin's lymphoma) and 12 healthy volunteers. No significant difference was found in the serum levels of IL-6 and C-Reaective Protein (CRP) between two groups. The other parameters (serum lactic dehydrogenase, fibrinogen, copper, a-2 globulin, erythrocyte sedimentation rate) were significantly higher in patients. Serum IL-6 levels were found to correlate to CRP. Serum IL-6 levels were not significatly .different in patients with and without systemic "B" symptoms (weight loss, fever and night sweats) in the different histologic subtypes and clinical stages.

Özet

lnterlökin-6 (IL-6) birçok hastalıkta patogenetik ve prognostik anlamı olan güçlü bir immünömodülatuar sitokindir. Bu çalışmada, biz malign lenfomalı 20 has¬tada (10 Hodgkin hastalığı, 10 Hodgkin dışı lenfoma¬lı) ve 12 sağlıklı gönüllüde serum IL-6 düzeylerini ölç¬tük. İki grup arasında serum IL-6 ve C-Reaktif Protein (CRP) düzeylerinde anlamlı bir fark bulunma¬dı. Diğer parametreler (Serum laktik dehidrogenaz, fibrinojen, bakır, a-2 globulin, eritrosit sedimentasyon hızı) hastalarda anlamlı olarak daha yüksekti. Hasta grubunda serum IL-6 düzeylerinin CRP ile korelas¬yon gösterdiği bulundu. Farklı histolojik subgrup ve evredeki hastalar ile, sistemik "B" semptomları (kilo kaybı, ateş ve gece terlemeleri) olan ve olmayanlar¬da serum IL-6 düzeyleri arasında anlamlı bir fark bu¬lunmadı.

🔖

Cite This Article

ÖZTÜRK, A., YAYLACI, M., KANDEMİR, E. G., ALTAŞ, A., ÜSKENT, N. (2022). Serum interleukin-6 levels in patients with malignant lymphoma. Gülhane Askeri Tıp Akademisi Bülteni, Cilt: 39 - Sayı: 1, 15–19. https://ajindex.com/articles/651126