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Journals / Eurasian Journal of Medical Investigation / 2021 / Cilt: 5 - Sayı: 1

Everolimus-Induced Oral Mucositis Can be Prevented by Hippophae Rhamnoides Extract in Rats

Arzu GEZER
İbrahim ÇİL
Bahadır SÜLEYMAN
Fatih ÖZÇİÇEK
Hüseyin Salih SEMİZ
Baran AKAGÜNDÜZ
Muhammet ÖZER
Nazım Can DEMİRCAN
Mehmet AKTAŞ
Halis SÜLEYMAN
Pages
81–88
Publication Date
2022-11-06
DOI
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We also analyzedthe differences between groups with Kruskal–Wallis test and Mann–Whitney U-test.Results: HRE significantly decreased MDA and increased tGSH levels and reduced IL-1β and TNF-α gene expression inboth tissues administered everolimus (p

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Objective & Hypothesis:Objectives: Oral mucositis is a significant toxicity related to the mammalian target of rapamycin inhibitor everolimus.
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Key Findings & Data:Malondialdehyde (MDA) and total glutathione (tGSH) levels along with interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha(TNF-α) gene expression levels were measured in the tongue and buccal mucosa tissues of all groups, histopathologicalchanges were also evaluated.
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Conclusion & Impact:We also analyzedthe differences between groups with Kruskal–Wallis test and Mann–Whitney U-test.Results: HRE significantly decreased MDA and increased tGSH levels and reduced IL-1β and TNF-α gene expression inboth tissues administered everolimus (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Oral mucositis is a significant toxicity related to the mammalian target of rapamycin inhibitor everolimus. Oxidative stress and pro-inflammatory cytokines, which contribute to treatment-related mucositis, can betargeted with Hippophae rhamnoides extract (HRE). Herein, we assessed the effects of HRE on everolimus-inducedmucositis in rats.Methods: Eighteen rats were equally divided into healthy, everolimus, and everolimus plus HRE groups. Malondialdehyde (MDA) and total glutathione (tGSH) levels along with interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha(TNF-α) gene expression levels were measured in the tongue and buccal mucosa tissues of all groups, histopathologicalchanges were also evaluated. We tested the significance of variations with one-way variance analysis. We also analyzedthe differences between groups with Kruskal–Wallis test and Mann–Whitney U-test.Results: HRE significantly decreased MDA and increased tGSH levels and reduced IL-1β and TNF-α gene expression inboth tissues administered everolimus (p

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Cite This Article

GEZER, A., ÇİL, İ., SÜLEYMAN, B., ÖZÇİÇEK, F., SEMİZ, H. S., AKAGÜNDÜZ, B., ÖZER, M., DEMİRCAN, N. C., AKTAŞ, M., SÜLEYMAN, H. (2022). Everolimus-Induced Oral Mucositis Can be Prevented by Hippophae Rhamnoides Extract in Rats. Eurasian Journal of Medical Investigation, Cilt: 5 - Sayı: 1, 81–88. https://ajindex.com/articles/650390

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