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Journals / BEYOGLU EYE JOURNAL / 2022 / Cilt: 7 - Sayı: 3

Investigation of eNOS G894T Gene Polymorphism in Patients with Pseudoexfoliation Syndrome: A Preliminary Study

Özer DURSUN
Ayca YILMAZ
Senay BALCI FİDANCI
Lülüfer TAMER
Mustafa VATANSEVER
Ömer ÖZER
Erdem DİNÇ
Pages
188–192
Publication Date
2022-11-06
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Results: While the mean age in the control group was 65.97±10.64 years (23 males and 15 females), the mean age in the study group was 73.05±6.79 years (30 males and 10 females), (p

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Objective & Hypothesis:Objectives: The aim of this study is to investigate the relationship between pseudoexfoliation syndrome (XFS) and pseudoexfoliative glaucoma (XFG) and endothelial nitric oxide synthase (eNOS) G894T polymorphism.
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Key Findings & Data:Methods: Seventy-eight eyes of 78 patients who had undergone uncomplicated cataract surgeries for senile cataract were included in this study.
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Conclusion & Impact:Results: While the mean age in the control group was 65.97±10.64 years (23 males and 15 females), the mean age in the study group was 73.05±6.79 years (30 males and 10 females), (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: The aim of this study is to investigate the relationship between pseudoexfoliation syndrome (XFS) and pseudoexfoliative glaucoma (XFG) and endothelial nitric oxide synthase (eNOS) G894T polymorphism. Methods: Seventy-eight eyes of 78 patients who had undergone uncomplicated cataract surgeries for senile cataract were included in this study. Forty patients with XFS were included in the study group, and 38 patients without XFS constituted the control group. Patients with XFS were divided into two subgroups according to their XFG development, and subgroup analysis was performed. Venous blood samples were taken from all patients before surgery and 894 G>T (rs1799983) polymorphism on the eNOS gene was evaluated by RT-PCR. Results: While the mean age in the control group was 65.97±10.64 years (23 males and 15 females), the mean age in the study group was 73.05±6.79 years (30 males and 10 females), (p

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Cite This Article

DURSUN, Ö., YILMAZ, A., FİDANCI, S. B., TAMER, L., VATANSEVER, M., ÖZER, Ö., DİNÇ, E. (2022). Investigation of eNOS G894T Gene Polymorphism in Patients with Pseudoexfoliation Syndrome: A Preliminary Study. BEYOGLU EYE JOURNAL, Cilt: 7 - Sayı: 3, 188–192. https://ajindex.com/articles/649063

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References (15)

  1. Streeten BW, Li ZY, Wallace RN, Eagle RC Jr., Keshgegian AA. Pseudoexfoliative fibrillopathy in visceral organs of a patient with pseudoexfoliation syndrome. Arch Ophthalmol 1992;110:1757–62
  2. Rinvold A. Pseudoexfoliation and aortic aneurysms. Lancet 2001;357:2139–40
  3. Repo LP, Suhonen MT, Teräsvirta ME, Koivisto KJ. Color Doppler imaging of the ophthalmic artery blood flow spectra of patients who have had transient ischemic attack. Correlations with generalized iris transluminance and pseudoexfoliation syndrome. Ophthalmology 1995;102:1199–205
  4. Repo LP, Terasvirta ME, Koivisto KJ. Generalized transluminance of the iris and the frequency of the pseudoexfoliation syndrome in the eyes of transient ischemic attack patients. Ophthalmology 1993;100:352–5
  5. Mitchell P, Wang JJ, Smith W. Association of exfoliation syndrome with increased vascular risk. Am J Ophthalmol 1997;124:685–7
  6. Miglior S, Bertuzzi F. Exfoliative glaucoma: New evidence in the pathogenesis and treatment. Prog Brain Res 2015;221:233–41
  7. Plateroti P, Plateroti AM, Abdolrahimzadeh S, Scuderi G. Pseudoexfoliation syndrome and pseudoexfoliation glaucoma: A review of the literature with updates on surgical management. J Ophthalmol 2015;2015:370371
  8. Taube AB, Konzer A, Alm A, Bergquist J. Proteomic analysis of the aqueous humour in eyes with pseudoexfoliation syndrome. Br J Ophthalmol 2019;103:1190–4
  9. Yimaz A, Adigüzel U, Tamer L, Yildirim O, Oz O, Vatansever H, et al. Serum oxidant/antioxidant balance in exfoliation syndrome. Clin Exp Ophthalmol 2005;33:63–6
  10. Yilmaz A, Tamer L, Ates NA, Yildirim O, Yildirim H, Atik U. Is GST gene polymorphism a risk factor in developing exfoliation syndrome? Curr Eye Res 2005;30:575–81
  11. Zierhut M, Cadenas E, Rao NA. Free Radicals in Ophthalmic Disorders. 1st ed. London: Informa; 2008. p. 1–10
  12. Zhao Y, Vanhoutte PM, Leung SW. Vascular nitric oxide: Beyond eNOS. J Pharmacol Sci 2015;129:83–94
  13. Diler SB, Öden A. The T-786C, G894T, and intron 4 VNTR (4a/b) polymorphisms of the endothelial nitric oxide synthase gene in prostate cancer cases. Genetika 2016;52:249–54
  14. Yao HX, Ma FZ, Tan YY, Liu LY. Endothelial nitric oxide synthase gene polymorphisms and risk of erectile dysfunction: An updated Meta-analysis of genetic association studies. Int J Surg 2018;54:141–4
  15. Azarpira MR, Ghilian MM, Sobhan MR, Mahdinezhad-Yazdi M, Aghili K, Ahrar H, et al. Association of eNOS 27-bp VNTR, 894G>T and 786T>C polymorphisms with susceptibi