Journals / Viral Hepatitis Journal / 2020 / Cilt: 26 - Sayı: 2

Seroprevalence of Hepatitis A in Children Followed-up with the Diagnosis of Chronic Hepatitis B Infection

Kronik Hepatit B Enfeksiyonu Nedeniyle Takip Edilen Çocuklarda Hepatit A Seroprevalansı

Pages
74–77
Publication Date
2022-11-06
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Morbidity and mortality dueto HAV infection can be prevented by vaccinating non-immunepatients

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: To investigate the seroprevalence of hepatitis A virus(HAV) infection in children with chronic hepatitis B virus (HBV)infection and to immunize patients who did not have anti-HAVimmunoglobulin (Ig) G level in protective titer.Materials and Methods: A retrospective analysis was made in79 children with chronic HBV infection between January 2017 andDecember 2018.Results: Of the patients with a mean age of 11.5±4.6 years(1-18 years), 64.6% were boys and 35.4% were girls (male/female=51/28).
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Key Findings & Data:Anti-HAV (Ig) G was positive in 72.2% (n=57)of the cases.
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Conclusion & Impact:Morbidity and mortality dueto HAV infection can be prevented by vaccinating non-immunepatients
🔬Design:Research Article
📍Scope:2017 Verileri
⚙️Variables:Domain Parameters

Abstract

Objectives: To investigate the seroprevalence of hepatitis A virus(HAV) infection in children with chronic hepatitis B virus (HBV)infection and to immunize patients who did not have anti-HAVimmunoglobulin (Ig) G level in protective titer.Materials and Methods: A retrospective analysis was made in79 children with chronic HBV infection between January 2017 andDecember 2018.Results: Of the patients with a mean age of 11.5±4.6 years(1-18 years), 64.6% were boys and 35.4% were girls (male/female=51/28). Anti-HAV (Ig) G was positive in 72.2% (n=57)of the cases. According to gender, the rate of sero-positivity wasfound to be 72.5% (n=37) in boys and 71.4% (n=20) in girls. HAVimmunization was determined at the lowest rate (8.1%) in the 14-18years age group. Although 3 patients vaccinated against HAV wereanti HAV-IgG negative, and 39 patients who were not vaccinatedwere anti-HAV IgG positive.Conclusion: The seroprevalence of HAV should also be evaluatedin children with chronic HBV infection. Morbidity and mortality dueto HAV infection can be prevented by vaccinating non-immunepatients

Özet

Amaç: Kronik hepatit B virüs (HBV) enfeksiyonu olan çocuklardaki hepatit A virüs (HAV) enfeksiyonu seroprevalansının araştırılması ve koruyucu titrede anti-HAV immünoglobulin (Ig) G düzeyine sahip olmayan hastaları bağışıklama amaçlanmıştır. Gereç ve Yöntemler: Ocak 2017 ile Aralık 2018 tarihleri arasında kronik HBV enfeksiyonu tanısı ile izlenen 79 çocuk hastanın tıbbi kayıtları geriye dönük olarak incelendi. Bulgular: Yaş ortalaması 11,5±4,6 yıl (1-18 yıl) olan hastaların %64,6’sı erkek, %35,4’ü kız idi (Erkek/Kadın=51/28). Olguların %72,2’sinde (n=57) anti-HAV immünoglobulin (Ig) G pozitif bulundu. Cinsiyete göre, sero-pozitiflik oranının erkeklerde %72,5 (n=37), kızlarda ise %71,4 (n=20) oranlarında olduğu belirlenmiştir. On dört-18 yaş grubu olgularda HAV bağışıklamasının en düşük oranda (%8,1) olduğu tespit edilmiştir. HAV’ye karşı aşılanmış 3 hastada anti HAV-IgG negatif olmasına karşın, aşılanmamış 39 hastada anti-HAV IgG pozitif bulundu. Sonuç: Kronik HBV enfeksiyonu olan çocuklarda HAV seroprevalansının da değerlendirilmesi gerekir. Bağışık olmayan hastaların aşılanması ile HAV enfeksiyonuna bağlı morbidite ve mortalite önlenebilir.

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Cite This Article

DEVECİ, U., ACAR, U. (2022). Seroprevalence of Hepatitis A in Children Followed-up with the Diagnosis of Chronic Hepatitis B Infection. Viral Hepatitis Journal, Cilt: 26 - Sayı: 2, 74–77. https://ajindex.com/articles/646343

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