Journals / Van Tıp Dergisi / 2018 / Cilt: 25 - Sayı: 4

Venlafaxine Intoxication and Serotonin Syndrome

Venlafaksin İntoksikasyonu ve Serotonin Sendromu

Pages
535–537
Publication Date
2022-11-04
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We aimed to present a 10.5 gr long venlafaxine intoxication with rhabdomyolysis, muscle rigidity and epileptic seizures.

📌 3 Key Takeaways

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Objective & Hypothesis:A second-generation antidepressant called venlafaxine serotonin and norepinephrine reuptake inhibitors (SNRI).
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Key Findings & Data:Venlafaxine is used in the treatment of depression, anxiety and attention deficit hyperactivity disorder in children and adolescents.
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Conclusion & Impact:We aimed to present a 10.5 gr long venlafaxine intoxication with rhabdomyolysis, muscle rigidity and epileptic seizures.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

A second-generation antidepressant called venlafaxine serotonin and norepinephrine reuptake inhibitors (SNRI). Venlafaxine is used in the treatment of depression, anxiety and attention deficit hyperactivity disorder in children and adolescents. Compared with tricyclic antidepressants, tolerance and safety profiles of SNRI’s are positive, and their use in terms of patient compliance and overdosage is increasing day by day. Symptoms that should be paid attention to in severe toxicity are CNS (central nervous system) depression, serotonin syndrome and cardiac conduction abnormalities. We aimed to present a 10.5 gr long venlafaxine intoxication with rhabdomyolysis, muscle rigidity and epileptic seizures.

Özet

Venlafaksin; serotonin ve norepinefrin geri alım inhibitörleri (SNRI) olarak isimlendirilen ikinci nesil bir antidepresandır. Venlafaksin çocuk ve ergenlerde depresyon, anksiyete ve dikkat eksikliği hiperaktivite bozukluğu tedavisinde kullanılmaktadır. Trisiklik antidepresanlar ile karşılaştırıldıklarında SNRI’ların tolerabilite ve güvenlik profilleri olumlu olup, hasta uyumu ve doz aşımı açısından da kullanımı gün geçtikçe artmaktadır. Ciddi toksisitede en çok dikkat edilmesi gereken semptomlar SSS (santral sinir sistemi) depresyonu, serotonin sendromu ve kardiyak iletim anormallikleridir. Biz rabdomyoliz, kas rijiditesi ve epileptik nöbetleri olan toplam 10,5 gr uzun salınımlı venlafaksin zehirlenmesini sunmayı amaçladık.

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Cite This Article

AVCI, O., YÖRÜK, M. F., DEMİR, G. Ç. (2022). Venlafaxine Intoxication and Serotonin Syndrome. Van Tıp Dergisi, Cilt: 25 - Sayı: 4, 535–537. https://ajindex.com/articles/645996

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References (6)

  1. Johnson EM, Whyte E, Mulsant BH, Pollock BG, Weber E, Begley AE, et al. Cardiovascular changes associated with venlafaxine in the treatment of late-life depression. Am J Geriatr Psychiatry 2006; 14(9): 796-802.
  2. Doğan BE. "Serotonin Syndrome, Rhabdomyolysis and Cardiovascular Toxicity in Venlafaxine Poisoning: A Case Report." Kocatepe Medical Journal 2012; 13: 173-175.
  3. Koçak O, Yarar C, Çarman KB, Işık İ. Ciddi Bir İlaç Reaksiyonu: Serotonin Sendromu İKSST Derg 2015; 7(3): 144-146. Sternbach H. The serotonin syndrome. Am J Psychiatry 1991; 148(6): 705-713.
  4. Wilson AD, Howell C, Waring WS. Venlafaxine ingestions is associated with rhabdomyolosis in adults. The J of ToxicolSci 2007; 32 (1): 97-101.
  5. Hojer J, Hulting J, Salmonson H. Fatal cardiotoxicity induced by venlafaxine overdosage. ClinToxicol (Phila) 2008; 46(4): 336-337.
  6. Mazur JE, Doty JD Kyrygiel AS. Pharmocotherapy 2003; 23(12): 1668-1672. Ateş MA. Venlafaksinin Uzun Salınımlı Formunun Kullanımı Sonucu Tetiklenen Epileptik Nöbet: Bir Olgu Sunumu Nöropsikiyatri Arşivi 2008; 45: 62-64.