Journals / Ulusal Travma ve Acil Cerrahi Dergisi / 2019 / Cilt: 25 - Sayı: 2

Neuroendocrine tumor of the appendix: Twelve years of results from a single institution

Apendiksin nöroendokrin tümörü: Bir kurumun 12 yıllık sonuçları

Pages
118–122
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In addition, the study revealed that disease-free survival (100%) was good over a mean follow-up of 59.2 months.

📌 3 Key Takeaways

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Objective & Hypothesis:BACKGROUND: The aim of this study was to investigate the incidence of appendiceal neuroendocrine tumors (NET) in an acuteappendicitis cohort, as well as to investigate the behavioral form of the tumor.
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Key Findings & Data:Our secondary aim was to investigate survival in patientswith appendiceal NET.METHODS: Between February 2006 and June 2018, 6518 appendectomies were performed for acute appendicitis in the departmentof surgery, University of Health Sciences, Okmeydanı Education and Research Hospital, İstanbul, Turkey.
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Conclusion & Impact:In addition, the study revealed that disease-free survival (100%) was good over a mean follow-up of 59.2 months.
🔬Design:Research Article
📍Scope:2006 Verileri
⚙️Variables:Domain Parameters

Abstract

BACKGROUND: The aim of this study was to investigate the incidence of appendiceal neuroendocrine tumors (NET) in an acuteappendicitis cohort, as well as to investigate the behavioral form of the tumor. Our secondary aim was to investigate survival in patientswith appendiceal NET.METHODS: Between February 2006 and June 2018, 6518 appendectomies were performed for acute appendicitis in the departmentof surgery, University of Health Sciences, Okmeydanı Education and Research Hospital, İstanbul, Turkey. The medical records of theseconsecutive 6518 appendectomy patients were evaluated retrospectively. After the histopathological analysis, a total of 22 patientswere identified as cases of appendiceal NET. These patients were included in the study. A retrospective analysis of data includinggender, age, intraoperative surgical findings, duration of postoperative follow-up and survival, tumor localization, the diameter of thetumor, tumor grade, invasion, surgical margin, and stage of the tumor was performed.RESULTS: The incidence of appendiceal NET was 0.33%. Eleven patients were diagnosed as primary pathological stage pT1aN0M0according to the European Neuroendocrine Tumor Society guidelines. One patient was diagnosed as primary pathological stagepT1bN0M0, and 10 patients were diagnosed as primary pathological stage pT2N0M0. The median tumor diameter was 7.6 mm. Therewas no patient with a tumor diameter greater than 20 mm.CONCLUSION: The incidence of appendiceal NET in our study is consistent with that stated in the literature. The results of ourresearch suggest that further surgical procedures for NETs that occur coincidentally in patients of the AA cohort are often unnecessary. In addition, the study revealed that disease-free survival (100%) was good over a mean follow-up of 59.2 months.

Özet

AMAÇ: Akut apandisit tanısıyla apendektomi yapılan hasta topluluğunda apendiks nöroendokrin tümörlerinin (NET) görülme sıklığını ve tümörün davranış şeklini araştırmayı amaçladık. İkincil amacımız apandisiyel NET’li hastalarda sağkalımı araştırmaktır. GEREÇ VE YÖNTEM: Şubat 2006–Haziran 2018 tarihleri arasında Sağlık Bilimleri Üniversitesi İstanbul Okmeydanı Eğitim ve Araştırma Hastanesi Genel Cerrahi Kliniği’nde akut apendisit tanısıyla 6518 apendektomi uygulandı. Bu ardışık 6518 apendektomi hastasının tıbbi kayıtları geriye dönük olarak değerlendirildi. Histopatolojik analizlerden sonra toplam 22 hasta apendiks NET olarak tanımlandı. Bu hastalar çalışmaya dahil edildi. Cinsiyet, yaş, ameliyat sırasında cerrahi bulgular, ameliyat sonrası takip süresi ve sağkalım süresi, tümör lokalizasyonu, tümör çapları, tümör derecesi, invazyon, cerrahi sınır ve tümör evresi gibi geriye dönük bir veri tabanı elde edildi. BULGULAR: Apendiks NET’lerinin görülme sıklığı %0.33 idi. On bir hastaya Avrupa Nöroendokrin Tümör Derneği Kılavuzu’na göre primer patolojik evre pT1aN0M0 tanısı konuldu. Ayrıca bir hastaya primer patolojik evre pT1bN0M0 ve on hastaya primer patolojik evre pT2N0M0 tanısı konuldu. Ortalama tümör çapı 7.6 mm idi. Tümör çapı 20 mm’den daha büyük olan herhangi bir hasta yoktu. TARTIŞMA: Çalışmadaki apendiks NET görülme sıklığı literatür ile uyumludur. Çalışmanın sonuçları akut apandisit hastalarında rastlantısal olarak ortaya çıkan NET’ler için daha ileri cerrahi işlemlerin gereksiz olduğunu göstermektedir. Buna ek olarak, çalışma hastalıksız sağkalımın (%100), ortalama 59.2 aylık takipte iyi olduğunu göstermektedir.

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Cite This Article

Hot, S., Kamalı, S., Gökçek, B., Karakaş, D. Ö., Eğin, S., Yeşiltaş, M., Kamalı, G. (2022). Neuroendocrine tumor of the appendix: Twelve years of results from a single institution. Ulusal Travma ve Acil Cerrahi Dergisi, Cilt: 25 - Sayı: 2, 118–122. https://ajindex.com/articles/644250

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