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Journals / Ulusal Travma ve Acil Cerrahi Dergisi / 2020 / Cilt: 26 - Sayı: 1

Evaluation of rat major celluler prion protein for early diagnosis in experimental rat brain trauma model

Deneysel beyin travması oluşturulan sıçanlarda erken tanı için sellüler prion protein(PrPC)’nin değerlendirilmesi

Sezgin SARIKAYA
Aysun TOKER
Halil DOĞAN
Nurten SEVER
Alev KURAL
Şebnem TEKİN NEIJMANN
Pages
1–8
Publication Date
2022-11-06
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

Brain specimenswere obtained for the pathological examination.RESULTS: Serum S100B and PrPC levels were found to increase in T group at both 2h and 24h after trauma (p

📌 3 Key Takeaways

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Objective & Hypothesis:BACKGROUND: Although traumatic brain injury (TBI) is an important problem, there has been no widespread utilization of neurobiomarkers to aid the diagnosis of TBI.
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Key Findings & Data:This study was conducted to evaluate serum S100B and prion protein (PrPC) levels in rats with TBI.METHODS: In this study, 15 albino rats were categorized into three groups as follows: sham-operated (1), control (6) and trauma (8)groups.
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Conclusion & Impact:Brain specimenswere obtained for the pathological examination.RESULTS: Serum S100B and PrPC levels were found to increase in T group at both 2h and 24h after trauma (p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

BACKGROUND: Although traumatic brain injury (TBI) is an important problem, there has been no widespread utilization of neurobiomarkers to aid the diagnosis of TBI. This study was conducted to evaluate serum S100B and prion protein (PrPC) levels in rats with TBI.METHODS: In this study, 15 albino rats were categorized into three groups as follows: sham-operated (1), control (6) and trauma (8)groups. The TBI model was based on the modified free falling model. S100B, PrPC levels were measured using ELISA. Brain specimenswere obtained for the pathological examination.RESULTS: Serum S100B and PrPC levels were found to increase in T group at both 2h and 24h after trauma (p

Özet

AMAÇ: Travmatik beyin yaralanması önemli bir problem olmasına rağmen, tanıda yardımcı olan yaygın kullanımlı bir nöro-biyobelirteç yoktur. Bu çalışma, S100B ve prion protein (PrPC) düzeylerini travmatik beyin yaralanması oluşturulan sıçanlarda değerlendirmeyi amaçlamaktadır. GEREÇ VE YÖNTEM: On beş albino cinsi sıçan; sham (1), kontrol (6) ve travma (8) olarak üç gruba ayrıldı. Travmatik beyin yaralanması modifiye serbest düşme modeli ile oluşturuldu. S100B, PrPC düzeyleri ELISA yöntemi ile ölçüldü. Beyin örnekleri patolojik inceleme için çıkarıldı. BULGULAR: Serum S100B ve PrPc düzeyleri travma grubunda, travmadan sonraki 2. ve 24. saatlerde yüksek bulundu (sırasıyla, p

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Cite This Article

SARIKAYA, S., TOKER, A., DOĞAN, H., SEVER, N., KURAL, A., NEIJMANN, Ş. T. (2022). Evaluation of rat major celluler prion protein for early diagnosis in experimental rat brain trauma model. Ulusal Travma ve Acil Cerrahi Dergisi, Cilt: 26 - Sayı: 1, 1–8. https://ajindex.com/articles/644196

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