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Journals / Türk Pediatri Arşivi / 2002 / Cilt: 30 - Sayı: 3

Effects of mechanical ventilation strategies on haemodynamics, airway pressures and arterial blood gases

Tavşanlarda mekanik ventilasyon stratejilerinin hemodinami, hava yolu basınçları ve arter kan gazlarına etkileri

Ramazan UZAN
Hüseyin ÖZ
Meyancı Güniz KÖKSAL
Pages
105–110
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

PaO2 values of group 1 was lower than the other groups (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The aim of this study was to investigate the effects of different mechanical ventilation strategies on hemodynamics airway pressures and arterial blood gases in healthy rabbits.
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Key Findings & Data:Twenty New Zealand rabbits were randomly divided into 4 equal groups (n=5).
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Conclusion & Impact:PaO2 values of group 1 was lower than the other groups (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The aim of this study was to investigate the effects of different mechanical ventilation strategies on hemodynamics airway pressures and arterial blood gases in healthy rabbits. Twenty New Zealand rabbits were randomly divided into 4 equal groups (n=5). Tracheostomy was performed in all animals undergoing ketamine (50 mg/kg, im) anaesthesia. After tracheostomy, all animals were ventilated with FiO2:1.0, respiratory rate: adjusted initial PaCO2 levels 35-45 mmHg for 180 minutes. Small tidal volume+Zero PEEP, I/E:l/2 was applied to group 1, Small tidal volume+10 cmH2O PEEP, 1/E.1/2 was applied to group 2, High tidal volume+Zero PEEP, I/E:l/2 was applied to group 3 and small tidal volume+Inverse ratio ventilation (I/E:2/1) was applied to group 4. There was no significant difference between groups regarding Mean arterial pressure and heart rate. PaO2 values of group 1 was lower than the other groups (p

Özet

Çalışmamızda, kullandığımız çeşitli mekanik ventilasyon stratejilerinin sağlıklı tavşanlarda hemodinami, hava yolu basınçları ve arter kan gazları üzerine olan etkilerini araştırmayı amaçladık. Yirmi adet Yeni Zelanda tipi albino tavşan rasgele 4 eşit gruba ayrıldı (n=5). Tavşanların hepsine ketamin anestezisi altında (50 mg/kg, İM) trakeostomi açıldı. Trakeostomi sonrası FiO2:1.0, solunum frekansı başlangıç PaCO2'si 35-45 mmHg olacak şekilde ayarlandı ve 180 dk süreyle ventile edildiler. Birinci gruba düşük volüm (DV:5 mL/kg)+ZEEP (sıfır PEEP), Inspirium/Ekspirium (İ / E):l / 2, 2. gruba DV+PEEP (10 cmH2O), İ / E:1/ 2, 3. gruba yüksek volüm (YV:30 mL/kg)+ZEEP, İ / E:1/ 2, 4. gruba ise DV+IRV ("inverse ratio ventilation") (2/1) uygulandı. Hayvanların ortalama arter basınçları (OAB), kalp atım hızları (KAH), "Ppeak", "Ppause", "Pmean" havayolu basınçları, kompliyansları ve arter kan gazları değerleri (AKG) takip edildi. Gruplar arası OAB, KAH'da istatistiki fark bulunamadı. PaO2 değerinin 1. grupta diğer gruplara göre düştüğü görüldü (p

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Cite This Article

UZAN, R., ÖZ, H., KÖKSAL, M. G. (2022). Effects of mechanical ventilation strategies on haemodynamics, airway pressures and arterial blood gases. Türk Pediatri Arşivi, Cilt: 30 - Sayı: 3, 105–110. https://ajindex.com/articles/641779

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References (12)

  1. Vincent JL: lung protection during mechanical ventilation. In: Yearbook of Intensive Care and Emergency Medicine 1999, Ed. By. JL Vincent, Springer-Berlin, 1999; p.269-70
  2. Slutsky AS: Lung injury caused by mechanical ventilation. Chest 1999; 116:95-155
  3. Slutsky AS: Consensus conference on mechanical ventilation-January 28-30,1993 at Northbrook Illinois, USA. Part 2- Intensive Care Medicine 1994; 20:150-62
  4. Vincent JL: Lung protection during mechanical ventilation. In: Yearbook of Intensive Care and Emergency Medicine 1998, Ed. By. JL Vincent, Springeer-Berlin, 1998; p.469-70
  5. Dreyfuss D, Simon G: Role of tidal volum, FRC, and end-inspiratory volum in the development of pulmonary edema following mechanical ventilation. Am Rev Respir Dis 1993; 148:1194-203
  6. Dreyfuss D, Soler P, Baset G, Simon G: High inflation pressure pulmonary edema. Am Rev respir Dis 1986; 137:1169-1264
  7. Brochard L, Thorovol FR, Raupie E: Tidal volume reduction for prevention of ventilator-induced lung injury in acute respiratory distress syndrome. Am J Respir Crit Care Med 1998; 158:1831-38
  8. Parker JC, Hernandez LA, Langeneker GL: Lung edema caused by high pik inspiratory pressures in dogs. Am Rev Respir Dis; 1990; 142:321-28
  9. Muscedere TG, Mullen JBM, Gan K, Slutsky AS: Tidal ventilation at low airway pressure can augment lung injury. Am J Crit Care Med 1994; 149:1327-34
  10. Argiras EP,Blakeley CR, Dunhill MS: High PEEP decreases hyaline membrane formation in surfactan deficient lungs. Brit J Anaesth 1987; 59:1278-85
  11. Jardin F, Desfond P, Bazin M, Sportiche M, Margairaz A: Controlled ventilation with best positive end expiratory pressure (PEEP) and high level PEEP in acute respiratory failure (ARF). A comparative study on patients with lateral and unilateral lung disease. Intens Care Med 1981; 7:171-76
  12. Kolobow T, Moretti MP, Fumgalli R: Severe impairment in lung function induced by high peak airway pressure during mechanical ventilation. Am Respir Dis 1987; 135:312-15.