Objective: Pregnancy-associated plasma protein A (PAPP-A), a metalloproteinase thatregulates insulinlike growth factor-1 bioavailability in vitro, has been suggested to play anactive role in the pathophysiology of several conditions involving inflammatory responses.We investigated the values of PAPP-A and high sensitive CRP (hsCRP) levels in chronicsubdural haematoma (CSDH) patients and healthy controls.Methods: PAPP-A and hsCRP levels were studied in the serum and subdural haematomafluid of 20 consecutive patients with CSDHs (M / F: 12 / 8; mean age of 56.7) and in theserum of age matched 16 volunteers (M / F: 10 / 6; mean age: 54,2).Results: The serum PAPP-A [4.15 ng/mL (2.70-12.88)] levels of patients were significantlylower than control group [9.32 ng/mL (6.5717.00)] (p
📌 3 Key Takeaways
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Objective & Hypothesis:Objective: Pregnancy-associated plasma protein A (PAPP-A), a metalloproteinase thatregulates insulinlike growth factor-1 bioavailability in vitro, has been suggested to play anactive role in the pathophysiology of several conditions involving inflammatory responses.We investigated the values of PAPP-A and high sensitive CRP (hsCRP) levels in chronicsubdural haematoma (CSDH) patients and healthy controls.Methods: PAPP-A and hsCRP levels were studied in the serum and subdural haematomafluid of 20 consecutive patients with CSDHs (M / F: 12 / 8; mean age of 56.7) and in theserum of age matched 16 volunteers (M / F: 10 / 6; mean age: 54,2).Results: The serum PAPP-A [4.15 ng/mL (2.70-12.88)] levels of patients were significantlylower than control group [9.32 ng/mL (6.5717.00)] (p
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Key Findings & Data:Objective: Pregnancy-associated plasma protein A (PAPP-A), a metalloproteinase thatregulates insulinlike growth factor-1 bioavailability in vitro, has been suggested to play anactive role in the pathophysiology of several conditions involving inflammatory responses.We investigated the values of PAPP-A and high sensitive CRP (hsCRP) levels in chronicsubdural haematoma (CSDH) patients and healthy controls.Methods: PAPP-A and hsCRP levels were studied in the serum and subdural haematomafluid of 20 consecutive patients with CSDHs (M / F: 12 / 8; mean age of 56.7) and in theserum of age matched 16 volunteers (M / F: 10 / 6; mean age: 54,2).Results: The serum PAPP-A [4.15 ng/mL (2.70-12.88)] levels of patients were significantlylower than control group [9.32 ng/mL (6.5717.00)] (p
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Conclusion & Impact:Objective: Pregnancy-associated plasma protein A (PAPP-A), a metalloproteinase thatregulates insulinlike growth factor-1 bioavailability in vitro, has been suggested to play anactive role in the pathophysiology of several conditions involving inflammatory responses.We investigated the values of PAPP-A and high sensitive CRP (hsCRP) levels in chronicsubdural haematoma (CSDH) patients and healthy controls.Methods: PAPP-A and hsCRP levels were studied in the serum and subdural haematomafluid of 20 consecutive patients with CSDHs (M / F: 12 / 8; mean age of 56.7) and in theserum of age matched 16 volunteers (M / F: 10 / 6; mean age: 54,2).Results: The serum PAPP-A [4.15 ng/mL (2.70-12.88)] levels of patients were significantlylower than control group [9.32 ng/mL (6.5717.00)] (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Objective: Pregnancy-associated plasma protein A (PAPP-A), a metalloproteinase thatregulates insulinlike growth factor-1 bioavailability in vitro, has been suggested to play anactive role in the pathophysiology of several conditions involving inflammatory responses.We investigated the values of PAPP-A and high sensitive CRP (hsCRP) levels in chronicsubdural haematoma (CSDH) patients and healthy controls.Methods: PAPP-A and hsCRP levels were studied in the serum and subdural haematomafluid of 20 consecutive patients with CSDHs (M / F: 12 / 8; mean age of 56.7) and in theserum of age matched 16 volunteers (M / F: 10 / 6; mean age: 54,2).Results: The serum PAPP-A [4.15 ng/mL (2.70-12.88)] levels of patients were significantlylower than control group [9.32 ng/mL (6.5717.00)] (p
Özet
Amaç: In vitro koşullarda insulin benzeri büyüme faktörü-1 biyoaktivitesini düzenleyen birmetalloproteinaz olan Gebelik ilişkili plazma proteini-A'nın (PAPP-A),inflamatuar yanıtiçeren birçok durumun patofizyolojisinde rol oynadığı bildirilmiştir. Bu çalışmada kroniksubdural hematomlu (KSDH) hastalar ve sağlıklı kontrollerdeki PAPP-A ve yüksek duyarlıCRP (hsCRP) düzeylerini araştırdık.Metod: KSDH'lı 20 ardışık hastanın (E/K: 12/8; ortalama yaş 56.7) serum ve subduralhematom sıvısında ve yaş uyumlu 16 sağlıklı gönüllünün (E/K: 10/6; ortalama yaş 54.2)serumunda PAPP-A ve hsCRP düzeyleri araştırılmıştır.Bulgular: Hasta grubunun serum PAPP-A düzeyleri [4.15 ng/mL (2.70-12.88)] kontrolgrubuna göre [9.32 ng/mL (6.5717.00)] anlamlı olarak düşüktü (p
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Cite This Article
BIÇEROGLU, H., UZAN, M., ELMACI, İ., HANIMOĞLU, H., BALAK, N., COŞKUN, A., MEMISOGULLARI, R., İŞ, M., ULU, M. O., TÜRECI, E. (2022). Kronik Subdural Hematomlu Hastalarda Gebelik İlişkili Plazma Proteini-A ve Yüksek Duyarlı C-Reaktif Protein Düzeyleri. Journal of Neurological Sciences (Turkish), Cilt: 28 - Sayı: 3, 330–336. https://ajindex.com/articles/565363
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