AI Summary & Key Takeaways
AI InsightThe nuclear size was the sole differential cytopathologic criteria between follicular adenoma and follicular carcinoma (p
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Abstract
Aim: Our aim is to determine the minimal cytopathologic criteria needed to make differential diagnosis in follicular-patterned lesions of the thyroid gland. Materials and Methods: We reviewed 56 fine needle aspiration cytology specimens which were reported as “suspicious for follicular-patterned lesions of thyroid” between years 2001 and 2005 in our hospital and their histological slides. Parameters for cytopathologic assesment are cellularity, colloid formation, multilayered rosette formation, follicular cell rings, monolayered sheets, intact follicles, hyperplastic papillae, hyaline stromal fragments, intranuclear inclusions, nuclear grooves, angulated nuclei, nucleoli, cerebriform nuclei, nuclear size, macrophages, flame cells and Hurthle cells. Statistical analysis was performed using χ2 and Fisher's-exact tests and Kolmogorov-Simirnov test.Results: Four cytopathologic features–cerebriform nuclei, angulated nuclei, nuclear grooves and intranuclear inclusion- were constantly observed in the follicular variant of papillary carcinoma (p< 0.05). Diluted colloid, monolayered sheet, nuclear size, macrophage and nucleoli were frequently seen in nodular hyperplasia (p< 0.05). The nuclear size was the sole differential cytopathologic criteria between follicular adenoma and follicular carcinoma (p
Özet
Amaç: Çalışmanın amacı tiroidin folliküler patern yapan lezyonlarının ayırıcı tanısındaki minimal sitopatolojik kriterleri saptamaktır. Gereç ve Yöntem: Hastanemiz sitopatoloji ünitesinde 2001 ve 2005 yılları arasında “folliküler patern yapan tiroid lezyonu şüphesi” tanısı alan 56 ince iğne aspirasyon sitolojisi materyali değerlendirmeye alındı. Sitopatolojik değerlendirmede kullanılan parametreler: hücresellik, kolloid yapısı, çok sıralı rozet yapısı, folliküler hücre dizilimleri, tek sıralı tabakalar, intakt folliküller, hiperplastik papilla, hyalin stromal fragmanlar, intranükleer inklüzyonlar, nükleer yarıklar, angüle nükleus, nükleol, serebriform nükleus, nükleer boyut, makrofajlar, flame hücreler ve Hürthle hücreleri idi. İstatistik analiz χ2 and Fisher-Exact Tests ve Kolmogorov-Simirnov Test kullanılarak yapıldı.Bulgular: Papiller karsinom foliküler alt tipinde dört sitopatolojik özellik- serebriform nükleus, angule nükleus, nükleer yarık ve intranükleer inklüzyon- saptanmıştır (p