AI Summary & Key Takeaways
AI InsightThe SIRT1 gene was upregulated in all tumor stage subgroups except stage I, femalepatients, young patients (≤45 years), and corpus and cardia tumor subgroups compared to the control group.Conclusion: SIRT1 gene overexpression is associated with gastric adenocarcinoma, and it can be argued that SIRT1 gene upregulationis associated with unfavorable gastric adenocarcinoma prognosis.
📌 3 Key Takeaways
Özet
Background/Aims: SIRT1 gene overexpression is reportedly associated with cancer development, via the triggering of DNA repair impairment, and cell proliferation. The study aimed to investigate SIRT1 expression in patients with gastric cancer and its correlations withthe clinical and pathological characteristics of the disease.Materials and Methods: All patients (64 patients) who underwent gastric biopsy and were diagnosed with gastric adenocarcinoma andsignet ring cell carcinoma between January 2011 and December 2013 were enrolled in the study, and patients with benign gastric biopsywere enrolled in the control group (34 patients). The previously prepared gastric tissues were collected from the pathology department,and SIRT1 gene expressions were evaluated in the gastric tissues of all study patients. Patients were subclassified according to theirdemographic, clinical, and pathologic features, and the patient and control groups were compared.Results: Sixty-four patients were included in the study (25 females and 39 males). The mean age of the patients was 66±1 (range: 33-88) years. The SIRT1 gene 2’ Average delta cycle threshold (CT) value was 0.102 in the control group, whereas it was 0.292 in the patientswith gastric cancer (relative risk: 2.86; p=0.014). The SIRT1 gene was upregulated in all tumor stage subgroups except stage I, femalepatients, young patients (≤45 years), and corpus and cardia tumor subgroups compared to the control group.Conclusion: SIRT1 gene overexpression is associated with gastric adenocarcinoma, and it can be argued that SIRT1 gene upregulationis associated with unfavorable gastric adenocarcinoma prognosis.