AI Summary & Key Takeaways
AI InsightThere were no significant associations found between thrombophilia studies and radiographic outcomes at three months’ follow-up.
📌 3 Key Takeaways
Abstract
Aims: Thrombosis in pediatrics differs from that in adults and is mainly provoked. The main triggers include central venous catheterization, critical illness, infection, and immobilization. The factors associated with illness severity and short-term outcome in hospitalized children without cancer remain poorly defined. The aim of this study was to identify such factors and to describe short-term radiological outcomes. Methods: In this retrospective study, hospitalized non-cancer children (≤18 years old) with thrombosis were studied from October 2024 to July 2025. Data on demographics, risk factors, D-dimer levels, thrombophilia testing, treatment modalities, and radiographic responses at 1 and 3 months after diagnosis were collected. Results: Eighty-eight children (median age 2.0 years, IQR 0.0-11.2 years); 58.0% males. All thrombosis episodes occurred in the venous system, and 62.5% were related to the use of catheters. Immobility (48.9%) and sepsis (40.9%) emerged as the predominant risk factors. D-dimer median was 520 ng/ml (IQR 200-1136), with significantly higher levels observed among ICU/palliative care units than in other wards (p<0.001). Factor V Leiden was detected in 26.0% of genetically tested patients, all in the heterozygous state. Among evaluable patients, partial or complete radiological resolution was observed in 97.6% at 3 months. Conclusion: In hospitalized children without malignancy, thrombosis was predominantly provoked and was associated with central venous catheter exposure and underlying systemic illness. Independent association between d-dimers and high acuity of care indicates that d-dimers reflect systemic illness burden. There were no significant associations found between thrombophilia studies and radiographic outcomes at three months’ follow-up.