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Journals / Türk Patoloji Dergisi / 2011 / Cilt: 27 - Sayı: 1

Servikovajinal yayma'da LSIL/ASC-H (LSIL-H): Histopatolojik sonuçlar ve klinik önem

LSIL/ASC-H (LSIL-H) in cervicovaginal smear: Histopathological outcomes and clinical significance

Davut ŞAHİN
Handan ÇETİNER
Işık Ecmel KAYGUSUZ
Pages
46–50
Publication Date
2022-11-05
DOI
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⚡ TL;DR(Too Long; Didn't Read)

However, LSIL/ ASC-H was more frequently associated with a definitive histological diagnosis of any CIN2 than ASC-H (30% vs. 8%).Conclusion: Based on our results, we recommend LSIL/ASC-H to be added to Bethesda System, and Pap test cases of LSIL/ASC-H may need to be clinically followed-up in a manner similar to ASC-H, i.e., with colposcopy for all patients.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Conventional Pap smears exhibiting unequivocal features of ‘low grade squamous intraepithelial lesion' (LSIL) are occasionally mixed with some cells suspicious for, but not diagnostic of ‘high grade squamous intraepithelial lesion' (HSIL) on daily routine.
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Key Findings & Data:The 2001 Bethesda System does not address the significance of such cytological entities.
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Conclusion & Impact:However, LSIL/ ASC-H was more frequently associated with a definitive histological diagnosis of any CIN2 than ASC-H (30% vs. 8%).Conclusion: Based on our results, we recommend LSIL/ASC-H to be added to Bethesda System, and Pap test cases of LSIL/ASC-H may need to be clinically followed-up in a manner similar to ASC-H, i.e., with colposcopy for all patients.
🔬Design:Research Article
📍Scope:2001 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: Conventional Pap smears exhibiting unequivocal features of ‘low grade squamous intraepithelial lesion' (LSIL) are occasionally mixed with some cells suspicious for, but not diagnostic of ‘high grade squamous intraepithelial lesion' (HSIL) on daily routine. The 2001 Bethesda System does not address the significance of such cytological entities. We have referred to these changes in our laboratory as ‘LSIL, atypical squamous cells cannot exclude HSIL' (LSIL/ASC-H). In this study, we aimed to compare the cytology and biopsy results of LSIL/ ASC-H to LSIL, ASC-H and HSIL.Material and Method: Out of 37884 cases which were evaluated between 2005-2009 in our laboratory, cases interpreted as LSIL, LSIL/ ASC-H, HSIL and ASC-H were reevaluated and 153 cases for which biopsy materials were available were selected.Results: The rate of histological CIN2 or worse associated with LSIL/ ASC-H (45%) was between the rates of LSIL (10%) and HSIL (65%), but not significantly different from ASC-H (50%). However, LSIL/ ASC-H was more frequently associated with a definitive histological diagnosis of any CIN2 than ASC-H (30% vs. 8%).Conclusion: Based on our results, we recommend LSIL/ASC-H to be added to Bethesda System, and Pap test cases of LSIL/ASC-H may need to be clinically followed-up in a manner similar to ASC-H, i.e., with colposcopy for all patients.

Özet

Amaç: Günlük uygulamada, ‘low grade squamous intraepithelial lesion' (LSIL) bulguları ile birlikte ‘high grade squamous intraepithelial lesion' (HSIL) için tanısal olmamakla beraber kuşkulu hücreler içeren konvansiyonel Pap yaymalar olabilmektedir. Bethesda 2001 sistemi bu antiteye yer vermemiştir. Laboratuvarımızda bu tür değişiklikler gösteren konvansiyonel Pap yaymalara ‘HSIL dışlanamayan atipik skuamöz hücreler içeren LSIL (LSIL/ASC-H) tanısı vermekteyiz. Çalışmamızda; LSIL/ASC-H ile LSIL, HSIL ve ASC-H' li olguların sitoloji ve biyopsi sonuçlarını karşılaştırmayı hedefledik.Gereç ve Yöntem: Laboratuvarımızda 2005-2009 yılları arasında değerlendirilmiş 37884 olgu içerisinden LSIL, LSIL/ASC-H, HSIL ve ASC-H olarak tanı almış olgular yeniden değerlendirildi ve biyopsi materyalleri bulunan 153 olgu seçildi.Bulgular: LSIL/ASC-H ile ilişkili histolojik olarak CIN2 ve üzeri bir lezyon bulunma oranı (%45), LSIL (%10) ve HSIL (%65) arasında bir değer iken ASC-H (%50)'den anlamlı olarak farklı değildi. Bununla birlikte, ASC-H'ye göre LSIL/ASC-H (%8 e karşılık %30) daha sıklıkla, CIN2 tanısı ile ilişkili idi.Sonuç: Çalışma sonuçlarımıza bağlı olarak; LSIL/ASC-H'nin Bethesda sistemi'ne eklenmesini ve Pap test sonuçları LSIL/ASC-H olan olguların klinik olarak ASC-H gibi izlenmesini (bütün olgulara kolposkopi yapılması, vb.) önermekteyiz.

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Cite This Article

ŞAHİN, D., ÇETİNER, H., KAYGUSUZ, I. E. (2022). Servikovajinal yayma'da LSIL/ASC-H (LSIL-H): Histopatolojik sonuçlar ve klinik önem. Türk Patoloji Dergisi, Cilt: 27 - Sayı: 1, 46–50. https://ajindex.com/articles/640721

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References (1)

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