SavedAdd your journal

Journals / Türk Patoloji Dergisi / 2015 / Cilt: 31 - Sayı: 3

Dedifferentiated Liposarcoma with Peculiar Meningothelial-Like Whorling and Metaplastic Bone Formation, Case Report

Meningotelyal Benzeri Girdapsı Yapılar ve Metaplastik Kemik Yapımı ile Karakterli Dediferansiye Liposarkom Olgusu

Duygu GÜREL
Aydanur KARGI
Pages
206–210
Publication Date
2022-11-04
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Here, we reportthis case because of the problems in differential diagnosis especiallyfor cases that have an extensive dedifferentiated component and theuncertainty of the biological behavior of these tumors.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Dedifferentiated liposarcoma represents a both morphologically andbiologically fascinating lesion in which transition from low-grade tohigh-grade nonlipogenic morphology within a well-differentiatedliposarcoma is observed.
📊
Key Findings & Data:A 59-year-old man presented with a pelvicretroperitoneal mass measuring 13x10x8 cm.
💡
Conclusion & Impact:Here, we reportthis case because of the problems in differential diagnosis especiallyfor cases that have an extensive dedifferentiated component and theuncertainty of the biological behavior of these tumors.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Dedifferentiated liposarcoma represents a both morphologically andbiologically fascinating lesion in which transition from low-grade tohigh-grade nonlipogenic morphology within a well-differentiatedliposarcoma is observed. A peculiar form of dedifferentiated liposar- coma characterized by a nonlipogenic component with a meningot- helial-like whorling pattern of growth and metaplastic bone forma- tion has been described. A 59-year-old man presented with a pelvicretroperitoneal mass measuring 13x10x8 cm. Histopathologicallythe mass consisted almost entirely of a dedifferentiated nonlipogeniccomponent with meningothelial-like whorling pattern, metaplasticcartilage and bone. Dedifferentiated liposarcoma with meningotheli- al-like whorling pattern has rarely been encountered. Here, we reportthis case because of the problems in differential diagnosis especiallyfor cases that have an extensive dedifferentiated component and theuncertainty of the biological behavior of these tumors.

Özet

Dediferansiye liposarkom, düşük ya da yüksek dereceli lipojenikolmayan komponetten iyi diferensiye liposarkom alanlarına geçişile karakterli lezyondur. Son zamanlarda nonlipojenik komponentinmeningotelyal benzeri girdapsı yapılar oluşturduğu, metaplastikosifikasyon alanlarının eşlik ettiği dediferansiye liposarkomtanımlanmıştır. Olgumuz pelvik retroperitonda yerleşimli, 13x10x8cm boyutlarda, büyük komponenti nonlipojenik özellikte olan,meningotelyal benzeri girdapsı yapılar oluşturan dediferansiyeliposarkom tanısı alan, 59 yaşında, erkek hastadır. Olgu bu özgünmorfolojiye sahip dediferansiye liposarkomların ender görülmesi,biyolojik davranışı ile ilgili farklı verilerin bulunması, nonlipojenikkomponentin baskın olduğu tümörlerde ayırıcı tanı zorluğu nedeniyleliteratüre katkıda bulunmak amacıyla sunulmuştur.

🔖

Cite This Article

GÜREL, D., KARGI, A. (2022). Dedifferentiated Liposarcoma with Peculiar Meningothelial-Like Whorling and Metaplastic Bone Formation, Case Report. Türk Patoloji Dergisi, Cilt: 31 - Sayı: 3, 206–210. https://ajindex.com/articles/640563

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (10)

  1. Dei Tos AP. Liposarcoma: New entities and evolving concepts. Ann Diagn Pathol. 2000;4:252-66
  2. Nascimento AG, Kurtin PJ, Guillou L, Fletcher CD. Dedifferenti- ated liposarcoma: A report of nine cases with a peculiar neuralli- ke whorling pattern associated with metaplastic bone formation. Am J Surg Pathol. 1998;22:945-55
  3. Fanburg-Smith JC, Miettinen M. Liposarcoma with meningothe- lial-like whorls: A study of 17 cases of a distinctive histological pattern associated with dedifferentiated liposarcoma. Histopat- hology. 1998,33:414-24
  4. Kim SH, Choi YJ, Kim HJ, Yang WI. Liposarcoma with meningothelial-like whorls. Report of four cases showing diverse histologic findings and behavior. Yonsei Med J. 2003;44:392-400
  5. Thway K, Robertson D, Thway Y, Fisher C. Dedifferentiated liposarcoma with meningothelial-like whorls, metaplastic bone formation, and CDK4, MDM2, and p16 expression: A morphologic and immunohistochemical study. Am J Surg Pathol. 2011;35:356-63
  6. Matsumoto T, Fukunaga M, Fujii H, Arakawa A, Yamasaki S, Takase M, Kuwatsuru R, Ishii Y, Fujime M. Inguinal dedifferentiated liposarcoma with meningothelial-like whorls and metaplastic bone formation. Histopathology. 2005; 46:594-6
  7. Macarenco RS, Erickson-Johnson M, Wang X, Jenkins RB, Nascimento AG, Oliveira AM. Cytogenetic and molecular genetic findings in dedifferentiated liposarcoma with neural-like whorling pattern and metaplastic bone formation. Cancer Genet Cytogenet. 2006;171:126-9
  8. Song JS, Gardner JM, Tarrant WP, Shen S, Ayala AG, Yu E, Ro JY. Dedifferentiated liposarcoma with peculiar meningothelial-like whorling and metaplastic bone formation. Ann Diagn Pathol. 2009;13:278-84
  9. McCormic D, Mentzel T, Beham A, Fletcher CD. Dedifferentiated liposarcoma. Clinicopathologic analysis of 32 cases suggesting better prognostic subgroup among pleomorphic sarcomas. Am J Surg Pathol. 1994; 18:1213-23
  10. Hasegawa T, Seki K, Hasegawa F, Matsuno Y, Shimado T, Hirose T, Sano T, Hirohashi S. Dediferrentiated liposarcoma of retroperitoneum and mesentery: Varied growth patterns and histologic grades-a clinicopathologis study of 32 cases. Hum Pathol. 2000;31:717-27.