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Journals / Türk Patoloji Dergisi / 2020 / Cilt: 36 - Sayı: 1

The Effects of Corticosteroid Injection in the Healthy and Damaged Achilles Tendon Model: Histopathological and Biomechanical Experimental Study in Rats

Ahmet MİDİ
İlyas ARSLAN
Istemi YÜCEL
Nazım KARAHAN
M. Müfit ORAK
Turhan Beyza ÖZTÜRK
Pages
39–47
Publication Date
2022-11-06
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

There was no statisticallysignificant difference between the groups in terms of calcification.Conclusion: It has been found that there is biomechanical and histopathological significant benefit of intra-tendon corticosteroid administrationin the experimentally generated Achilles tendon injury model.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To show the effects of corticosteroids on inflammatory reactions in the injured Achilles tendon in rats.Material and Method: Thirty-two adult Wistar Albino rats were used in the study.
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Key Findings & Data:The rats were divided into 4 groups.
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Conclusion & Impact:There was no statisticallysignificant difference between the groups in terms of calcification.Conclusion: It has been found that there is biomechanical and histopathological significant benefit of intra-tendon corticosteroid administrationin the experimentally generated Achilles tendon injury model.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: To show the effects of corticosteroids on inflammatory reactions in the injured Achilles tendon in rats.Material and Method: Thirty-two adult Wistar Albino rats were used in the study. The rats were divided into 4 groups. In the first group (IntactSaline), saline solution was injected to the intact Achilles tendon. In the second group (Intact Corticosteroid), corticosteroid was injected tothe intact tendon. In the third group (Injured Saline), saline solution was injected to the injured Achilles tendon. In the fourth group (InjuredCorticosteroid), corticosteroid was injected to the injured tendon. All groups were sacrificed on day 30 and Achilles tendons were taken andprepared for histological and biomechanical evaluation.Results: According to the biomechanical test; mean load-to-failure of the Intact Saline group was significantly lower than the Intact Corticosteroid(p=0.016), Injured Saline (p=0.001) and Injured Corticosteroid) (p=0.012) groups. According to the histopathological evaluation, tenocytemean of the Intact Saline group was statistically lower than the Injured Saline and Injured Corticosteroid groups. Tenocyte mean of the IntactCorticosteroid group was statistically significantly lower than the Injured Saline and Injured Corticosteroid groups. The ground substancemean of the Intact Saline group was significantly lower than the Injured Saline and Injured Corticosteroid groups. The ground substance meanof the Intact Corticosteroid group was significantly lower than the Injured Saline and Injured Corticosteroid groups. There was no statisticallysignificant difference between the groups in terms of calcification.Conclusion: It has been found that there is biomechanical and histopathological significant benefit of intra-tendon corticosteroid administrationin the experimentally generated Achilles tendon injury model.

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Cite This Article

MİDİ, A., ARSLAN, İ., YÜCEL, I., KARAHAN, N., ORAK, M. M., ÖZTÜRK, T. B. (2022). The Effects of Corticosteroid Injection in the Healthy and Damaged Achilles Tendon Model: Histopathological and Biomechanical Experimental Study in Rats. Türk Patoloji Dergisi, Cilt: 36 - Sayı: 1, 39–47. https://ajindex.com/articles/640410

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References (14)

  1. Pingel J, Lu Y, Starborg T, Fredberg U, Langberg H, Nedergaard A, Weis M, Eyre D, Kjaer M, Kadler KE. 3-D ultrastructure and collagen composition of healthy and overloaded human tendon: Evidence of tenocyte and matrix buckling. J Anat. 2014; 224:548- 55
  2. Singh D. Acute Achilles tendon rupture. BMJ. 2015;351:h4722
  3. Frederick M. Azar. Traumatic Disorders, in campbell’s operative orthopaedics e-book, 9th ed. Elsevier Health Sciences, 2016; 1413-28
  4. Yang G, Rothrauff BB, Tuan RS. Tendon and ligament regeneration and repair: Clinical relevance and developmental paradigm. Birth Defects Res C Embryo Today. 2013;99:203-22
  5. Clanton TO, Haytmanek CT, Williams BT, Civitarese DM, Turnbull TL, Massey MB, Wijdicks CA, LaPrade RF. A biomechanical comparison of an open repair and 3 minimally invasive percutaneous achilles tendon repair techniques during a simulated, progressive rehabilitation protocol. Am J Sports Med. 2015;43:1957-64
  6. Svensson RB, Mulder H, Kovanen V, Magnusson SP. Fracture mechanics of collagen fibrils: Influence of natural cross-links. Biophys J. 2013;104:2476-84
  7. Meier Bürgisser G, Calcagni M, Bachmann E, Fessel G, Snedeker JG, Giovanoli P, Buschmann J. Rabbit achilles tendon full transection model - wound healing, adhesion formation and biomechanics at 3, 6- and 12-weeks post-surgery. Biol Open. 2016;5:1324-33
  8. Longo UG, Ronga M, Maffulli N. Achilles tendinopathy. Sports Med Arthrosc Rev. 2018;26:16-30
  9. Oliva F, Gatti S, Porcellini G, Forsyth NR, Maffulli N. Growth factors and tendon healing. Med Sport Sci. 2012; 57:53-64
  10. Curzi D, Salucci S, Marini M, Esposito F, Agnello L, Veicsteinas A, Burattini S, Falcieri E. How physical exercise changes rat myotendinous junctions: An ultrastructural study. Eur J Histochem. 2012;56: e19
  11. Frairia R, Berta L. Biological effects of extracorporeal shock waves on fibroblasts. A review. Muscles Ligaments Tendons J. 2012;1:138-47
  12. Burns PR, Lowery N. Etiology, pathophysiology, and most common injuries of the lower extremity in the athlete. Clin Podiatr Med Surg. 2011;28:1-18
  13. Müller SA, Quirk NP, Müller-Lebschi JA, Heisterbach PE, Dürselen L, Majewski M, Evans CH. Response of the injured tendon to growth factors in the presence or absence of the paratenon. Am J Sports Med. 2019;47:462-7
  14. Kaya Mutlu E, Celik D, Kılıçoğlu Ö, Ozdincler AR, Nilsson- Helander K. The Turkish version of the Achilles tendon Total Rupture Score: Cross-cultural adaptation, reliability and validity.