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Journals / Acta Orthopaedica et Traumatologica Turcica / 2015 / Cilt: 49 - Sayı: 4

Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats

Mehmet MÜFİT ORAK
Dursun AK
AHMET MİDİ
BERNA LAÇİN
Sevim PURİSA
GÜVEN BULUT
Pages
438–446
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Histomorphologically, knee joint samples were examined for osteoarthritic changes and stomach tissue samples for gastric changes.Results: Unlike methylprednisolone, diclofenac and tenoxicam caused increased fibrosis and fibroblast production; furthermore, chronic methylprednisolone use had no negative effects on the synovium or cartilage.Conclusion: Chronic tenoxicam and diclofenac use affects joints more negatively than chronic steroid treatment

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Lyophilized drug manufacturing and intra-articular (IA) applications have increased to address gastrointestinal side effects resulting from chronic treatment with non-steroidal anti-inflammatory drugs (NSAIDs) for degenerative joint disease.
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Key Findings & Data:Accordingly, we histologically examined joint and stomach tissues from rats to determine and compare the effects of long-term treatment with an IA corticosteroid (methylprednisolone acetate), lyophilized NSAID (tenoxicam), and non-lyophilized NSAID (diclofenac) following application to the knee joint.Methods: One hundred Wistar albino rats were divided into 4 groups of 25 rats: control, methylprednisolone, tenoxicam, and diclofenac.
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Conclusion & Impact:Histomorphologically, knee joint samples were examined for osteoarthritic changes and stomach tissue samples for gastric changes.Results: Unlike methylprednisolone, diclofenac and tenoxicam caused increased fibrosis and fibroblast production; furthermore, chronic methylprednisolone use had no negative effects on the synovium or cartilage.Conclusion: Chronic tenoxicam and diclofenac use affects joints more negatively than chronic steroid treatment
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Lyophilized drug manufacturing and intra-articular (IA) applications have increased to address gastrointestinal side effects resulting from chronic treatment with non-steroidal anti-inflammatory drugs (NSAIDs) for degenerative joint disease. Accordingly, we histologically examined joint and stomach tissues from rats to determine and compare the effects of long-term treatment with an IA corticosteroid (methylprednisolone acetate), lyophilized NSAID (tenoxicam), and non-lyophilized NSAID (diclofenac) following application to the knee joint.Methods: One hundred Wistar albino rats were divided into 4 groups of 25 rats: control, methylprednisolone, tenoxicam, and diclofenac. Ten IA injections were administered at 1-week intervals. Rats were sacrificed at 48 h and 1, 2, 4, and 8 weeks after the tenth injection. Histomorphologically, knee joint samples were examined for osteoarthritic changes and stomach tissue samples for gastric changes.Results: Unlike methylprednisolone, diclofenac and tenoxicam caused increased fibrosis and fibroblast production; furthermore, chronic methylprednisolone use had no negative effects on the synovium or cartilage.Conclusion: Chronic tenoxicam and diclofenac use affects joints more negatively than chronic steroid treatment

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Cite This Article

ORAK, M. M., AK, D., MİDİ, A., LAÇİN, B., PURİSA, S., BULUT, G. (2015). Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats. Acta Orthopaedica et Traumatologica Turcica, Cilt: 49 - Sayı: 4, 438–446. https://ajindex.com/articles/353573

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